Cord Blood News Volume 11.08 | Mar 7 2019

TOP STORY

A Topological View of Human CD34⁺ Cell State Trajectories from Integrated Single-Cell Output and Proteomic Data

Investigators report the results of integrating single-cell proteome measurements with clonally determined lymphoid, neutrophilic/monocytic, and/or erythroid progeny outputs from >1000 index-sorted CD34⁺ human cord blood cells in short-term cultures with and without stromal cells. [Blood] Abstract | Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Graft-versus-MDS Effect after Unrelated Cord Blood Transplantation: A Retrospective Analysis of 752 Patients Registered at the Japanese Data Center for Hematopoietic Cell Transplantation

Scientists conducted a retrospective study of the cord blood transplantation (CBT) outcomes in myelodysplastic syndrome (MDS) patients using the Japanese Data Center for Hematopoietic Cell Transplantation database. Seven hundred fifty-two de novo MDS patients of ≥18 years of age undergoing their first CBT between 2001 and 2015 were examined. [Blood Cancer J] Full Article

Effect of Human Amniotic Fluid Stem Cells on Kidney Function in a Model of Chronic Kidney Disease

Researchers demonstrated that administration of human-derived human amniotic fluid stem cells facilitated functional and structural improvement in a rat model of chronic kidney disease. [Tissue Eng Part A] Abstract

Infectious Complications after Umbilical Cord Blood Transplantation for Hematological Malignancy

Umbilical cord blood transplant (UCBT) is used for patients who do not have a matched donor, but engraftment often takes longer than with a standard allogeneic transplant, likely increasing the risk for infection. The authors characterized specific infections and outcomes in adults undergoing UCBT at two centers. [Open Forum Infect Dis] Full Article

Comparison and Cost Analysis of Three Protocols for Mobilization and Apheresis of Hematopoietic Progenitor Cells

The authors compared three protocols analyzing the effect of plerixafor, higher dose of G‐CSF and large volume leukapheresis. [J Clin Apher] Abstract

Comparison of Different Cryopreservation Protocols for Human Umbilical Cord Tissue as Source of Mesenchymal Stem Cells

There were no significant morphological and immunophenotypic differences between MSCs isolated from cryopreserved tissue groups and MSCs isolated from the fresh tissue group. According to the growth kinetic analysis, the cells isolated from the 1,2 propanediol group had a lower proliferation rate than the cells isolated from the fresh tissue. [Acta Histochem] Abstract

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Extracellular Vesicles: Squeezing Every Drop of Regenerative Potential of Umbilical Cord Blood

Collection, cryopreservation and transplantation of umbilical cord blood-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. [Metabolism] Full Article

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STEMCELL Technologies Wins Deloitte Best Managed Companies Award

STEMCELL Technologies announced that the company has been selected as a winner of Canada’s Best Managed Companies program for 2019. Canada’s Best Managed Companies is the country’s leading business awards program, recognizing excellence in the management abilities and practices of Canadian owned and managed companies with revenues over $15 million. [STEMCELL Technologies Inc.] Press Release

NIH Provides $23 Million for Statewide Translational Research Institute

The Integrated Translational Health Research Institute of Virginia has been awarded a five-year grant of nearly $23 million from the National Institutes of Health (NIH) to advance innovative ideas from the point of discovery to implementation in clinical practice and population health. [University of Virginia] Press Release

Head of US Food and Drug Agency Resigns

Scott Gottlieb, the head of the US Food and Drug Administration (FDA), resigned on 5 March and will depart the agency in one month. [Nature News] Editorial | Opinion

Trump Threatens to Cut Federal Research Funding over Free Speech

At the Conservative Political Action Conference, President Donald Trump promised to sign an executive order cutting off funds to colleges and universities that do not maintain free speech. The president said “it will be very costly” if institutions don’t comply, but he did not give many details about the possible executive order or who would decide if schools were adequately protecting free speech. [The Scientist] Editorial

China Creating National Medical Ethics Committee to Oversee High-Risk Clinical Trials

A powerful new national medical ethics committee, which will approve all clinical trials involving high-risk biomedical technologies, is at the center of a regulatory shakeup Chinese authorities are planning in the aftermath of the widely condemned “CRISPR babies” experiment, STAT has learned. [STAT News] Editorial

NEW ESH 5^th International Conference on Acute Myeloid Leukemia “Molecular and Translational”: Advances in Biology and Treatment
October 24-26, 2019
Estoril, Portugal

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NEW Postdoctoral Position – Stem Cells and Erythropoiesis (Karolinska Institutet)

NEW Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Scholarship – Proteomics and Erythropoiesis (Lund University)

Postdoctoral Position – Experimental Hematology (Leipzig Universitätsklinikum)

Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University)

Faculty Positions – Cancer Research (Shenzhen University)

Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University)

Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

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