TOP STORY
Researchers Find Solution to Cell Death Problem Vexing Stem Cell Research
Researchers show that a molecular motor, called “nonmuscle myosin II,” which exists naturally inside each human pluripotent stem (hPS) cell and controls various cellular functions, triggers the death of hPS cells when they are broken down to single cells. [Press release from the University of California, Riverside discussing online prepublication in Nature Communications]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Non-Muscle Myosin II Regulates Survival Threshold of Pluripotent Stem Cells
Researchers demonstrate that treatment with a specific inhibitor of non-muscle myosin II, blebbistatin, enhances the survival of human pluripotent stem cells under clonal density and suspension conditions, and, in combination with a synthetic matrix, supports a fully defined environment for self-renewal. [Nat Commun]
Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells
To examine the potential for xenogenic approaches in blastocyst complementation, researchers injected mouse or rat pluripotent stem cells (PSCs) into rat or mouse blastocysts, respectively, generating interspecific chimeras and thus confirming that PSCs can contribute to xenogenic development between mouse and rat. [Cell]
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
Findings indicate that Jak/Stat3 participate directly in molecular reprogramming and that activation of this pathway is a limiting component. [Cell Stem Cell]
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells
Researchers report that codeletion of c- and N-MYC in induced pluripotent stem cells and embryonic stem cells results in their spontaneous differentiation to primitive endoderm. [Cell Stem Cell]
Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed Through Intraspinal Transplantation
Current methods to examine and regulate the functional integration and plasticity of human embryonic stem cell (hESC)-derived neurons are cumbersome and technically challenging. Researchers engineered hESCs and their derivatives to express the light-gated Channelrhodopsin-2 protein to overcome these deficiencies. [Cell Stem Cell]
Functional Control of Transplantable Human ESC-Derived Neurons via Optogenetic Targeting
Researchers engineered human embryonic stem cells (hESCs) and their derivatives to express the light-gated Channelrhodopsin-2 protein to overcome deficiencies in current methods to examine and regulate the functional integration and plasticity of hESC-derived neurons. [Stem Cells]
High-Efficiency Induction of Neural Conversion in hESCs and hiPSCs with a Single Chemical Inhibitor of TGF-Beta Superfamily Receptors
Researchers identified compound C (also denoted as dorsomorphin), a protein kinase inhibitor, as a potent regulator of human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) fate decisions. [Stem Cells]
The Wnt/Beta-Catenin Signaling Pathway Tips the Balance Between Apoptosis and Reprogramming of Cell-Fusion Hybrids
The present study provides evidence that spontaneous fusion occurs, while the survival of the reprogrammed clones is strictly dependent upon induction of a Wnt-mediated reprogramming pathway. [Stem Cells]
Molecular Signature of Primary Retinal Pigment Epithelium and Stem Cell-Derived RPE Cells
Results establish a panel of molecular markers for evaluating the fidelity of human pluripotent stem cell to retinal pigment epithelium (RPE) conversion. [Hum Mol Genet]
Long-Term Human Pluripotent Stem Cell Self-Renewal on Synthetic Polymer Surfaces
Researchers identified several polymers that can support self-renewal of human pluripotent stem cells (hPSCs). While most of these polymers provide support for only a short period of time, they identified a synthetic polymer poly(methyl vinyl ether-alt-maleic anhydride) that supported the long-term attachment, proliferation and self-renewal of HUES1, HUES9, and iPSCs. [Biomaterials]
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INDUSTRY NEWS
iPierian Announces Second Close of $28 million Series B Financing
Pierian, Inc. announced the second closing of its Series B equity financing, bringing the total amount raised in this round to $28 million. [iPierian Press Release]
Forbion Capital Partners Raises EUR190 Million for New Investments
Forbion Capital Partners, a leading investment firm dedicated to the life science sector, announced the final closings of both FCF I Co-Invest Fund and of FCF II, raising a total of more than EUR190 million ($240 million). [Forbion Capital Partners Press Release]
Kansas State Awarded Patent for Stem Cell Procedures
Kansas State University has received a patent for procedures to develop what researchers called a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord. [The Wichita Eagle]
Cell Therapy Foundation Calls for Additional Research, Extensive Clinical Trials
Some of the most promising medical research conducted to treat diseases of the brain, heart, and circulatory system is moving too slowly to help millions of patients, according to the Cell Therapy Foundation, which advocates the use of adult stem cells to dramatically impact and improve the condition of patients who suffer from a variety of conditions. [PR Newswire]
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POLICY NEWS
Judge Upholds Stem Cell Funding Ban
A Washington, D.C., judge said that his ruling, halting all federal funding for human embryonic stem cell research, will stand while the case moves forward. Chief Judge Royce Lamberth, responding to a request from the Department of Justice that he stay his preliminary injunction, released a 3-page order denying the request. [United States District Court for the District of Columbia]
FDA Launches New Organizational Performance Management System
The U.S. Food and Drug Administration (FDA) launched an innovative performance management system designed to advance the President’s commitment to transparency, public participation, and collaboration in the work of government. [Food and Drug Administration, United States]
Medical School Leaders Express Support for Stem Cell Research in New Association of American Medical Colleges Ad [Association of American Medical Colleges, United States]
Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-126) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-22096) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-22128) [National Institutes of Health, United States]
Center for Scientific Review; Amended Notice of Meeting (FR Doc. C1-2010-22119) [National Institutes of Health, United States]
Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting (FR Doc. 2010-22107) [National Institutes of Health, United States]
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-22093) [National Institutes of Health, United States]
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EVENTS
International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece
Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States
Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia
NEW Third Annual Maryland Stem Cell Research Symposium
September 22, 2010
Gaithersburg, United States
5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany
5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany
Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
October 7, 2010
Hertfordshire, United Kingdom
Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany
BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia Select Biosciences 2nd International Forum on Stem Cells
November 12-13, 2010
Tianjin, China
Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada
Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States
Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States
Stem Cells World Congress
January 24-25, 2011
San Diego, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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