| PUBLICATIONS (Ranked by impact factor of the journal) | EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Researchers observed great similarity of epidermal growth factor receptor (EGFR) signaling and radiation survival in Cetuximab-treated squamous cell carcinomas cells grown in a more physiological three-dimensional extracellular matrix and as tumor xenografts in contrast to conventional monolayer cell cultures. [Cancer Res] Abstract Prediction of Equibiaxial Loading Stress in Collagen-Based Extracellular Matrix Using a Three-Dimensional Unit Cell Model The authors previously described a cellular solid model to predict fibril microstructure-mechanical relationships of reconstituted collagen matrices due to unidirectional loads. The model consisted of representative volume elements made up of an interconnected network of flexible struts. In this study, they extended this work by adapting the model to account for microstructural anisotropy of the collagen fibrils, and a biaxial loading environment. [Acta Biomater] Abstract Increased Expression of Intranuclear Matrix Metalloproteinase 9 in Atrophic Renal Tubules Is Associated with Renal Fibrosis Interstitial fibrosis correlated with matrix metalloproteinase 9 (MMP-9) expression in the atrophic tubular nuclei. The results of this study indicate that renal fibrosis is associated with a decline of MMP-9 expression in the cytoplasm of normal tubular cells and increased expression of MMP-9 in the nuclei of tubular atrophic renal tubules. [PLoS One] Full Article Investigating Cell-ECM Contact Changes in Response to Hypoosmotic Stimulation of Hepatocytes In Vivo with DW-RICM Researchers used two wavelength reflection interference contrast microscopy (DW-RICM) to directly observe the dynamics of cell-substrate contacts, mimicking cell-cellular matrix (ECM) interactions, in response to a controlled and well-defined volume change induced by hypoosmotic stimulation. This is the first time a non-invasive, label-free method was used to uncover a volume change related response of in vitro hepatocytes in real time. [PLoS One] Full Article Role of Matrix Metalloproteinases 2 and 9 in Ex Vivo Trypanosoma cruzi Infection of Human Placental Chorionic Villi Researchers analyzed the participation of matrix metalloproteases in the extracellular matrix remodeling during Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants. [Placenta] Abstract Extracellular Matrix Rigidity Controls Podosome Induction in Microvascular Endothelial Cells Liver fibrosis induces a dedifferentiation of liver sinusoidal endothelial cells (LSECs) leading notably to a loss of fenestrae. Since liver fibrosis is associated with increased matrix stiffness, and since substrate stiffness is known to regulate the actin cytoskeleton, the authors investigated the impact of matrix rigidity on podosome structures in LSECs. [Biol Cell] Abstract Relaxin 2 Is Functional at the Ocular Surface and Promotes Corneal Wound Healing Researchers aimed to determine if the insulin-like peptide hormone relaxin 2 (RLN2) is expressed at the ocular surface and tears and if RLN2 influences wound healing at the ocular surface, which is associated with extracellular matrix remodeling. [Invest Ophthalmol Vis Sci] Abstract PDLA/PLLA and PDLA/PCL Nanofibers with a Chitosan-Based Hydrogel in Composite Scaffolds for Tissue Engineered Cartilage The aim of this study was to create composite three dimensional scaffolds comprised of electrospun poly(D,L-lactide)/poly(L-lactide) (PDLA/PLLA) or poly(D,L-lactide)/polycaprolactone (PDLA/PCL) with salt leached pores and an embedded chitosan hydrogel to determine the potential of these scaffolds for cartilage tissue engineering. [J Tissue Eng Regen Med] Abstract Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is unknown. Researchers showed that apolipoprotein E (apoE) and apoE-containing high-density lipoprotein (apoE-HDL) maintain arterial elasticity by suppressing the expression of extracellular matrix genes. [Cell Rep] Abstract |
| INDUSTRY NEWS | BioTime Subsidiary OrthoCyte Corporation Announces the Appointment of Francois Binette as Vice President BioTime, Inc. and its subsidiary OrthoCyte Corporation announced the appointment of Francois Binette, PhD, as OrthoCyte’s Vice President of Research and Business Development. Dr. Binette’s primary focus will be to develop and partner near- and long-term product opportunities in regenerative medicine with an emphasis on orthopedic diseases and injuries. [BioTime, Inc.] Press Release Parios Regenerative Sciences, Inc. Licenses Exclusive Rights to Organic Nanotechnology for Skin Repair Parios Regenerative Sciences, Inc. has entered into a comprehensive license agreement with Brown University, licensing exclusive rights to a proprietary organic nanotechnology for use in dermatological applications. The nanotechnology, Oderm™, has clinical relevance in cosmetic skin rejuvenation, dermatological applications, and advanced wound care. [PR Newswire Association LLC] Press Release |
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