In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for Three-Dimensional Cellular Engineering Here, researchers suggest cucurbit[6]uril conjugated/diaminohexane conjugated hyaluronic acid hydrogels might be successfully exploited as a three-dimensional artificial extracellular matrix for various tissue engineering applications. [ACS Nano] Abstract Laminin Active Peptide/Agarose Matrices as Multifunctional Biomaterials for Tissue Engineering Here, researchers prepared functional polysaccharide matrices by mixing laminin active peptides and agarose gel. [Biomaterials] Abstract Biophysical Control of Invasive Tumor Cell Behavior by Extracellular Matrix Microarchitecture Using confocal reflectance microscopy and image autocorrelation analysis to quantitatively assess gel microarchitecture, researchers show that additional polymerization parameters including culture media formulation and gel thickness significantly affect the dimensions and organization of fibers and pores in collagen gels. [Biomaterials] Abstract Binding of Lassa Virus Perturbs Extracellular Matrix-Induced Signal Transduction via Dystroglycan Dystroglycan (DG) is a ubiquitous receptor for extracellular matrix proteins, which cooperates with β1 integrins to control cell-matrix interactions. Here, researchers investigated whether arenavirus Lassa virus binding to DG triggers signal transduction, mimicking the natural ligands. [Cell Microbiol] Abstract Stem Cell-Derived Extracellular Matrix Enables Survival and Multi-Lineage Differentiation within Superporous Hydrogels Intriguingly, researchers’ previous findings revealed that poly(ethylene glycol) diacrylate superporous hydrogel scaffolds allow anchorage of bone marrow derived human mesenchymal stem cells and support their long-term survival. Here, they hypothesized that the physicochemical characteristics of the scaffold impart properties that could foster cellular responses. [Biomacromolecules] Abstract The Orphan Histidine Protein Kinase SgmT Is a Cyclic-Dimeric-GMP Receptor and Regulates Composition of the Extracellular Matrix Together with the Orphan DNA Binding Response Regulator DigR in Myxococcus xanthus Proteins of two-component systems, including the orphan DNA binding response regulator DigR, are essential in regulating the composition of the extracellular matrix. Here, researchers identify the orphan hybrid histidine kinase SgmT as the partner kinase of DigR. [Mol Microbiol] Abstract Modification of Epidermal Growth Factor-Like Module 1 of Thrombospondin-1, an Animal Extracellular Protein, by O-Linked N-Acetylglucosamine Researchers’ results demonstrate that O-β-N-acetylglucosaminylation can occur on secreted extracellular matrix proteins as well as on cell surface proteins. [PLoS One] Abstract |