CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Vascular Endothelial Growth Factor and Fibroblast Growth Factor Prime Vascular Tube Morphogenesis and Sprouting Directed by Hematopoietic Stem Cell Cytokines Scientists demonstrate a novel, direct acting, and synergistic role for three hematopoietic stem cell cytokines, stem cell factor, interleukin-3 and stromal derived factor-1, in controlling human endothelial cell tube morphogenesis, sprouting, and pericyte-induced tube maturation under defined serum-free conditions in 3D matrices. [Blood] Controlled Architectural and Chemotactic Studies of 3D Cell Migration Researchers found that dendritic cell migration is characterized by a strong interplay between matrix architecture and chemotactic gradients, and migration is also influenced dramatically by the cell activation state. [Biomaterials] EMMPRIN: A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Researchers illustrate a novel involvement of extracellular matrix metalloproteinase inducer (EMMPRIN) in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. [J Neurosci] In Vitro Calcified Matrix Deposition by Human Osteoblasts onto a Zinc-Containing Bioactive Glass Researchers performed a detailed in vitro study of the biological reactivity of synthesized 58S bioactive glass containing-zinc, in terms of osteoblast morphology, proliferation, and deposition of a mineralized extracellular matrix. [Eur Cell Mater] Engineering Adipose Tissue from Uncultured Human Adipose Stromal Vascular Fraction on Gelatin Sponge and Collagen Matrix Scaffolds Results demonstrate that new adipose tissue can be regenerated by seeding freshly isolated, uncultured stromal vascular fraction on 3D porous collagen matrix and gelatin sponge scaffolds. [Tissue Eng Part A] High Amplitude Direct Compressive Strain Enhances Mechanical Properties of Scaffold-Free Tissue-Engineered Cartilage The short term influence of variable compressive strain amplitudes on mechanical and biochemical properties of scaffold-free tissue-engineered cartilage was investigated. [Tissue Eng Part A] Multi-Scale Biomimetic Topography for the Alignment of Neonatal and Embryonic Stem Cell-Derived Heart Cells By mimicking the fibrillar network of the extracellular matrix, the present system enables monitoring of protein localization in real time and therefore the high-resolution study of phenotypic and physiologic responses to in vivo like topographical cues. [Tissue Eng Part C Methods] Differential Response of Cartilage Oligomeric Matrix Protein (COMP) to Morphogens of Bone Morphogenetic Protein/Transforming Growth Factor-Beta Family in the Surface, Middle and Deep Zones of Articular Cartilage Researchers investigated the role of bone morphogenetic protein/transforming growth factor-beta superfamily members on COMP. [J Tissue Eng Regen Med] Hyaluronan Deposition and Correlation with Inflammation in a Murine Ovalbumin Model of Asthma The study investigates the processes involved in hyaluronan (HA) synthesis, deposition, localization and degradation during an acute and chronic murine model of ovalbumin-induced allergic pulmonary inflammation. [Matrix Biol] Induction of Type XVI Collagen Expression Facilitates Proliferation of Oral Cancer Cells Researchers demonstrate that overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 induction, increased Kindlin-1/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype. [Matrix Biol] TGF-Beta1 Diminishes Collagen Production During Long-Term Cyclic Stretching of Engineered Connective Tissue: Implication of Decreased ERK Signaling The study shows that a sequential stimulus approach — cyclic stretching with delayed TGF-beta1 supplementation — can be used to engineer tissue with desirable tensile and elastic properties. [J Biomechanics]
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