CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Dentin Matrix Protein 1 Induces Membrane Expression of VE-Cadherin on Endothelial Cells and Inhibits VEGF-Induced Angiogenesis by Blocking VEGFR-2 Phosphorylation Researchers demonstrated that the extracellular matrix protein, dentin matrix protein 1, induced the expression of VE-cadherin, a key regulator of intercellular junctions and contact inhibition of growth of endothelial cells that is also known to modulate VEGFR-2 activity, the major high affinity receptor for VEGF. [Blood] Biglycan Recruits Utrophin to the Sarcolemma and Counters Dystrophic Pathology in mdx Mice Researchers show that the extracellular matrix protein biglycan regulates utrophin expression in immature muscle and that recombinant human biglycan increases utrophin expression in cultured myotubes. [Proc Natl Acad Sci U S A] A Fibrin Patch-Based Enhanced Delivery of Human Embryonic Stem Cell-Derived Vascular Cell Transplantation in a Porcine Model of Postinfarction LV Remodeling Findings demonstrate a promising therapeutic potential of using these human embryonic stem cell-derived vascular cell types and the mode of patch delivery. [Stem Cells] Chimeric Fibronectin Matrix Mimetic as a Functional Growth- and Migration-Promoting Adhesive Substrate Researchers have developed recombinant fibronectin fragments that mimic the effects of extracellular matrix fibronectin on cell function by coupling the cryptic heparin-binding fragment of fibronectin’s first type III repeat (FNIII1H) to the integrin-binding domain (FNIII8-10). [Biomaterials] Role of Material-Driven Fibronectin Fibrillogenesis in Cell Differentiation Researchers demonstrate cell-free, material-induced fibronectin fibrillogenesis into a biological matrix with enhanced cellular activities. [Biomaterials] A Sandwich Model for Engineering Cartilage with Acellular Cartilage Sheets and Chondrocytes Acellular cartilage can provide a native extracellular matrix for cartilage engineering. However, it is difficult for cells to migrate into acellular cartilage because of its non-porous structure. The aim of this study was to establish a sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes. [Biomaterials] Ruthenium-Catalyzed Photo Cross-Linking of Fibrin-Based Engineered Tissue The purpose of this work was to investigate the use of a ruthenium-sodium persulfate cross-linking system to form dityrosine in fibrin-based engineered tissue. [Biomaterials] Self-Assembly of Elastin-Based Peptides into the ECM: The Importance of Integrins and the Elastin Binding Protein in Elastic Fiber Assembly Short elastin mimetic peptide sequences, EM-19 and EM-23, were engineered to mimic the active motifs of human elastin in hopes that they can stimulate extracellular matrix development in synthetic polymer scaffolds. [Biomacromolecules] Molecularly-Designed Alginate Hydrogels Susceptible to Local Proteolysis as 3D Cellular Microenvironments Results demonstrate that the co-incorporation of matrix metalloproteinase-labile peptides in cell-adhesive RGD-alginate hydrogels improved their performance as extracellular matrix analogues, providing a more dynamic and physiologic 3D cellular microenvironment. [Acta Biomater] Electrostatic Effects on Nanofiber Formation of Self-Assembling Peptide Amphiphiles Understanding the controlled formation of the hydrocolloid gels composed of peptide amphiphile nanofibers can lead researchers to develop in situ gel forming bioactive collagen mimetic nanofibers for various tissue engineering studies including bioactive surface coatings. [J Colloid Interface Sci]
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