A Novel Collagen-Nanohydroxyapatite MicroRNA-Activated Scaffold for Tissue Engineering Applications Capable of Efficient Delivery of Both miR-Mimics and antagomiRs to Human Mesenchymal Stem Cells Scientists introduced the first non-viral, non-lipid platform to date, capable of efficient delivery of mature microRNAs (miRNAs) molecules to human mesenchymal stem cells, a particularly difficult cell type to transfect effectively, with minimal treatment-associated cytotoxicity. [J Control Release] Abstract Hematopoietic Stem/Progenitor Cells Directly Contribute to Arteriosclerotic Progression via Integrin B2 Investigators demonstrate that Lin-Sca-1+cKit+ (LSK cells) in bone marrow and peripheral blood of LDLr-/- mice on high fat diet expressed significantly more integrin β2, which was responsible for LSK cell adhesion and migration toward ICAM-1 in vitro, and homing to injured arteries in vivo, all of which were blocked with an anti-CD18 blocking antibody. [Stem Cells] Abstract | Full Article Matrix Metalloproteinase 8 Degrades Apolipoprotein A-I and Reduces Its Cholesterol Efflux Capacity Researchers investigated whether matrix metalloproteinase-8 affects the structure and antiatherogenic function of apolipoprotein A-I, the main protein component of HDL particles. [FASEB J] Abstract Influence of Culture Conditions and Extracellular Matrix Alignment on Human Mesenchymal Stem Cells Invasion into Decellularized Engineered Tissues Investigators explored the influence of insulin and ascorbic acid and extracellular matrix alignment on the recellularization of decellularized engineered tissue by human mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts Researchers addressed the role of hyaluronan and its interaction with fibrillar matrix components during myofibroblast formation. Hyaluronan and fibronectin were increased and co-localized in the extracellular matrix following myofibroblast induction by TGF-β1. [Matrix Biol] Abstract Demineralized Bone Matrix Combined Bone Marrow Mesenchymal Stem Cells, Bone Morphogenetic Protein-2 and Transforming Growth Factor-β3 Gene Promoted Pig Cartilage Defect Repair Scientists investigated whether a combination of demineralized bone matrix and bone marrow mesenchymal stem cells infected with adenovirus-mediated- bone morphogenetic protein and transforming growth factor-β3 promotes the repair of the full-thickness cartilage lesions in pig model. [PLoS One] Full Article Electrospun Biomaterial Scaffolds with Varied Topographies for Neuronal Differentiation of Human-Induced Pluripotent Stem Cells Researchers investigated the effect of micro and nanoscale scaffold topography on promoting neuronal differentiation of human induced pluripotent stem cells and directing the resulting neuronal outgrowth in an organized manner. [J Biomed Mater Res A] Abstract Functional Impact of Integrin α5β1 on the Homeostasis of Intervertebral Discs: A Study of Mechanotransduction Pathways Using a Novel Dynamic Loading Organ Culture System Scientists aimed to reflect intervertebral disc (IVD) tissue response to mechanical stress using a dynamic loading organ culture system and to elucidate the functional impact of integrin α5β1 on the pathomechanism of IVD degeneration. [Spine J] Abstract |