Extracellular Matrix News Volume 7.31 | Aug 11 2016

TOP STORY

Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-Like Cells

Scientists report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells through modulation of the integrin-linked kinase ILK. [Cancer Res] Abstract

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Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes

Investigators found that culturing endothelial progenitor cells in high glucose media increased adhesion to bone marrow stromal cells. [Diabetes] Abstract

Combinatorial Extracellular Matrix Microenvironments Promote Survival and Phenotype of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells in Hypoxia

Researchers developed a combinatorial extracellular matrix (ECM) microarray platform to simultaneously interrogate hundreds of micro-scale multi-component chemical compositions of ECMs on induced pluripotent stem cell-derived endothelial cell response. [Acta Biomater] Abstract

Proplatelet Formation Is Selectively Inhibited by Collagen Type I via Syk-Independent GPVI Signaling

Investigators used megakaryocytes (MKs) lacking collagen receptors or treated MKs with blocking antibodies and could demonstrate that collagen I-mediated inhibition of proplatelet formation is specifically mediated by GPVI. [J Cell Sci] Abstract

Chemical Modification of Extracellular Matrix by Cold Atmospheric Plasma-Generated Reactive Species Affects Chondrogenesis and Bone Formation

Researchers investigated whether cold plasma generated by dielectric barrier discharge modifies extracellular matrices to influence chondrogenesis and endochondral ossification. [J Tissue Eng Regen Med] Abstract | Press Release

An Innovative Protocol for Schwann Cells Extracellular Matrix Proteins Extraction

The authors propose to solubilize Schwann cell extracellular matrix (ECM) through the use of surfactants and urea. They compared their method of solubilization, with one of that proposed in literature for a general ECM, mainly based on the use of enzymes. [J Biomed Mater Res A] Abstract

Laser-Sintered Constructs with Bio-Inspired Porosity and Surface Micro/Nano-Roughness Enhance Mesenchymal Stem Cell Differentiation and Matrix Mineralization In Vitro

Researchers examined osteoblast differentiation and matrix mineralization of human mesenchymal stem cells cultured on laser-sintered Ti-6Al-4V constructs with varying porosity and at different time scales. [Calcif Tissue Int] Abstract

Epigenetics of Epileptogenesis-Evoked Upregulation of Matrix Metalloproteinase-9 in Hippocampus

Investigators analyzed hippocampi extracted from adult and pediatric patients with temporal lobe epilepsy as well as from partially and fully pentylenetetrazole kindled rats. [PLoS One] Full Article

Effect of Laminin on Neurotrophic Factors Expression in Schwann-Like Cells Induced from Human Adipose-Derived Stem Cells In Vitro

Scientists revealed that laminin is a critical component in extracellular matrix of Schwann-like cells at in vitro. [J Mol Neurosci] Abstract

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

The authors describe the multistep assembly of actin-based invadopodia in molecular details. Mechanisms underlying membrane type 1-matrix metalloproteinase (MT1-MMP) traffic to invadopodia through endocytosis/recycling cycles, which are key to the invasive program of carcinoma cells, are discussed. [Annu Rev Cell Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Mallinckrodt to Acquire Stratatech Corporation, a Regenerative Medicine Company Focused on Proprietary Therapeutic Human Skin Substitute Products

Mallinckrodt plc announced that it has entered into a merger agreement with Stratatech Corporation, a privately held regenerative medicine company focused on the development of unique, proprietary skin substitute products. [Mallinckrodt plc] Press Release

Sorrento to Form Joint Venture with CHA Biotech to Develop and Commercialize Natural Killer Cell Therapies

Sorrento Therapeutics, Inc. announced that it has entered into a binding term sheet to create a joint venture with CHA Biotech Co., LTD (CBT), of South Korea to develop and commercialize proprietary chimeric antigen receptor (CAR) modified cellular therapies based on CBT’s activated killer cell technology and five of Sorrento’s CARs for all disease conditions, including oncology and infectious diseases. [Sorrento Therapeutics, Inc.] Press Release

The FDA Is Prohibited from Going Germline

A potentially renewable provision of the Consolidated Appropriation Act of 2016 forestalling the prospect of human germline modification was signed into law on December 18th, 2015. The provision has since been incorporated again into the House and Senate appropriation bills for the fiscal year. [ScienceInsider] Editorial

US Agency Lifts Ban on Funding Human–Animal Hybrids

Researchers in the United States will soon be able to resume creating chimaera-based projects. [Nature News] Editorial

Beyond CRISPR: A Guide to the Many Other Ways to Edit a Genome

The zeal with which researchers jumped on a possible new gene-editing system called NgAgo earlier this year reveals an undercurrent of frustration with CRISPR–Cas9 — and a drive to find alternatives. [Nature News] Editorial

NEW TERMIS Americas
December 11-14, 2016
San Diego, United States

Visit our events page to see a complete list of events in the community.

NEW Industrial Research Manager – Regenerative Medicine and Tissue Engineering (KU Leuven)

NEW PhD Position – Signal Transduction of Cell Migration (Bar-Ilan University)

NEW Postdoctoral Scientist – Diabetes Complications (Beth Israel Deaconess Medical Center)

Postdoctoral Fellowship – Epigenetic Mechanisms of Decellularized Extracellular Matrix on the Rejuvenation of Adult Stem Cells (West Virginia University)

Postdoctoral Position – Extracellular Matrix and the Regulation of Cancer Progression (University of Copenhagen)

Postdoctoral Researcher – Enamel Proteins and Biomineralization (University of California, San Francisco)

Faculty Positions – Cell Biology and Physiology (Washington University School of Medicine)

Postdoctoral Positions – Vascular Biology and Metabolism (University of Pittsburgh Medical Center)

Postdoctoral Scientist – Inflammatory Mechanisms Involved in Aortic Aneurysm (NYU Langone Medical Center)

Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO)

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