Extracellular Matrix News 8.04 February 2, 2017 | |
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TOP STORYCellular Mechano-Environment Regulates the Mammary Circadian Clock Scientists revealed that the breast epithelial clock is regulated by the mechano-chemical stiffness of the cellular microenvironment in primary cell culture. Moreover, the mammary clock is controlled by the periductal extracellular matrix in vivo, which contributes to a dampened circadian rhythm during ageing. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)αV-Class Integrins Exert Dual Roles on α5β1 Integrins to Strengthen Adhesion to Fibronectin The authors quantified the adhesion of αV-class and/or α5β1 integrins expressing fibroblasts initiating attachment to fibronectin by single-cell force spectroscopy. Their data revealed that αV-class integrins outcompete α5β1 integrins. Once engaged, αV-class integrins signal to α5β1 integrins to establish additional adhesion sites to fibronectin, away from those formed by αV-class integrins. [Nat Commun] Full Article The authors established that transforming growth factor-beta is required for self-sustaining extracellular matrix (D-ECM) production but dispensable for D-ECM-induced naïve fibroblast-to-cancer-associated fibroblast activation, which depends on αvβ5-integrin redistribution of pFAK-independent active α5β1-integrin to assorted endosomes. [eLife] Full Article Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth Scientists report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-breast cancer (BC) communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In mesenchymal stem/multipotent stromal cells isolated from human BC metastasis, DDR2 maintains a fibroblastic phenotype with collagen deposition and induces pathological activation of DDR2 signaling in BC cells. [Cell Rep] Full Article | Graphical Abstract Researchers investigated the molecular denaturation of collagen in the extracellular matrix decellularized by four commonly used cell-removing detergents: sodium dodecyl sulfate, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, sodium deoxycholate, and Triton X-100. [Acta Biomater] Abstract Investigators showed that low-dose vascular endothelial growth factor inhibition augmented with PDGF-R inhibition leads to superior vascular normalization without incremental extracellular matrix deposition thus maintaining access for therapy. [Br J Cancer] Abstract The authors described a highly effective adhesion culture of human pluripotent stem cells (hPSCs) using laminin fragments without precoating. Simple addition of laminin fragments to a cell suspension during passaging accelerated the adhesion of single dissociated hPSCs onto culture vessels that were not precoated with any culture substrate. [Sci Rep] Full Article Researchers developed a microfluidic-based a three-dimensional in vitro gastric cancer model, with subsequent drug resistance assay. AGS and Hs746T gastric cancer cell lines were encapsulated in collagen beads with high cellular viability. AGS exhibited an aggregation pattern with expansive growth, whereas Hs746T showed single-cell-level infiltration. [Sci Rep] Full Article Investigators found an extensive disruption of collagen synthesis and maturation pathways, as well as downregulation of the core elements of the TGF-β, Hippo, and Wnt signaling pathways influencing corneal organization. [Eur J Hum Genet] Abstract Scientists investigated the expression of islet amyloid polypeptide (IAPP) in degenerated inter vertebral discs tissue, and IAPP modulation of extracellular matrix metabolism in human nucleus pulposus cells, especially the crosstalk mechanism between apoptosis and autophagy in these cells. They found that the expression of IAPP and Calcr-receptor activity modifying proteins decreased considerably during intervertebral disc degeneration progression, along with the decrease in the expression of AG, BG, and Col2A1. [Cell Death Discov] Full Article | |
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REVIEWSExtracellular Vesicles in Coronary Artery Disease Investigators summarize current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents. [Nat Rev Cardiol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSLocate Therapeutics Deepens Development Collaboration with Heraeus Medical GmbH Locate Therapeutics announced the deepening of a development collaboration with the innovative orthopedic company, Heraeus Medical GmbH. The new deal focuses on the use of Locate’s “state of the art” TAOS® (Targeted, Orchestrated Signaling) scaffold technology, in new areas of orthopedic application. [Locate Therapeutics] Press Release SpinalCyte, LLC Enrolls First Patient in Landmark Phase I Human Clinical Trial SpinalCyte, LLC announced the enrollment of its first patient in a study for the development of CybroCell, the first dermal fibroblast cell product for treatment of degenerative disc disease. [SpinalCyte, LLC] Press Release Antibe Therapeutics Inc. announced that its subsidiary Citagenix Inc. has launched PentOS OI™ Max for the dental biologics market. PentOS OI™ Max is the newest member of the PentOS OI™ family of bone grafts for oral and maxillofacial surgery. [Antibe Therapeutics Inc.] Press Release | |
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EVENTSNEW Canadian Association for Clinical Microbiology and Infectious Diseases (CACMID) 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESProfessor – Molecular Biochemistry (University of Oulu) Faculty Positions – Medical Research (Pontificia Universidad Católica de Chile) PhD Studentship – Light-Addressable Neuroactive Matrices (KU Leuven) Postdoctoral Scientist – Various Projects (Cedars-Sinai Medical Center) Tenure Track Faculty Position – Kidney Bench Research (University of Pennsylvania) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Extracellular Matrix News Volume 8.04 | Feb 2 2017