Extracellular Matrix News 9.24 June 21, 2018 | |
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TOP STORYTissue Engineering toward Temporomandibular Joint Disc Regeneration Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. [Sci Transl Med] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors used nanofibrous superparamagnetic scaffolds with applied magnetic fields to build a “dynamic” scaffold platform and investigated the modulating effects of this platform on the phenotypes of fibroblasts. The results of enzyme-linked immunosorbent and transwell assays indicated that fibroblasts cultivated in this platform secreted significantly higher type I collagen, vascular endothelial growth factor A, and transforming growth factor-β1 and did so in a time-dependent manner. [ACS Appl Mater Interfaces] Abstract Researchers explored the chondroprotective effects of hyaluronic acid-chitosan nanoparticles containing plasmid DNA encoding CrmA (HA/CS-CrmA) in a rat osteoarthritis model. HA/CS-CrmA nanoparticles significantly inhibited cartilage damage, synovial inflammation, and the loss of type II collagen induced by anterior cruciate ligament transection. The expression levels of interleukin-1β, matrix metalloproteinase (MMP)-3, and MMP-13 in synovial tissue were dramatically down-regulated by HA/CS-CrmA nanoparticles. [Cell Physiol Biochem] Full Article SDF-1-Mediated Migration of MSCs Enhances Collagen Type II Expression in Intervertebral Disc The regenerative potential of a hyaluronan based (HA)-chemoattractant delivery system able to recruit mesenchymal stem cells (MSCs) seeded on the cartilaginous endplate of intervertebral disc (IVD) was explored. Investigators demonstrated that HA delivery system containing stromal cell derived factor-1 (SDF-1) increased MSCs recruitment, while the higher number of recruited cells partially contributed to accelerate matrix remodeling in nucleotomized IVDs. [Tissue Eng Part A] Abstract Orexin a Prevents Degradation of the Articular Matrixes in Human Primary Chondrocyte Culture Scientists characterized the protective effects of orexin A against interleukin-1β (IL-1β)-induced degradation of articular cartilage matrixes in human chondrocytes. Their results indicated that orexin-1 receptor (OX1R) but not orexin-2 receptor was expressed in human chondrocytes. They also found that the expression of OX1R was significantly lower in chondrocytes from osteoarthritis patients, and that treatment with IL-1β decreased the expression of OX1R in a dose-dependent manner. [Mol Immunol] Abstract Collagen as Coating Material for 45S5 Bioactive Glass-Based Scaffolds for Bone Tissue Engineering Highly porous 45S5 bioactive glass-based scaffolds were fabricated by the foam replica technique and coated with collagen by a novel method. The composite material developed in this study exhibited positive cell viability as well as suitable cell attachment and proliferation on the surface. [Int J Mol Sci] Full Article The impact of asiatic acid (AA) on collagen synthesis of fibroblast cell and cytotoxic effect of pegylated liposomal doxorubicin and doxorubicin to cancer cell were studied in vitro. In the presence of AA, the intratumor collagen level was restricted in vivo and in vitro. [Acta Pharmacol Sin] Abstract Researchers demonstrated that silibinin-induced autophagy is mediated by up-regulation of PPARα-sirt1-AMPK, contributing to repression of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes through down-regulation of phosphorylated NF-κB p65. [Mol Cell Biochem] Abstract Laminin α1 Orchestrates VEGFA Functions in the Ecosystem of Colorectal Carcinoma By employing mouse models expressing high and low levels of the laminin α1 chain (LMα1), scientists highlighted its implication in a tumor‐stroma crosstalk, thus leading to increased colon tumor incidence, angiogenesis and tumor growth. The underlying mechanism involved attraction of carcinoma‐associated fibroblasts by LMα1, VEGFA expression triggered by the complex integrin α2β1‐CXCR4 and binding of VEGFA to LM‐111, which in turn promoted angiogenesis, tumor cell survival and proliferation. [Biol Cell] Abstract | |
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REVIEWSThe authors explore and discuss recent data that implicates an active role for the ECM in the immune response to infection, encompassing antimicrobial activities, microbial recognition, macrophage activation, phagocytosis, leukocyte population balance and transcriptional and post-transcriptional regulation of inflammatory networks, and may foster novel antimicrobial approaches. [Immunology] Abstract | Full Article Recent Advances and Future of Gene Therapy for Bone Regeneration Gene therapy methods for bone regeneration are systematically becoming more efficient and show proof-of-concept in clinically relevant animal models. Yet, on the pathway to clinical use, more investigation is needed to determine the safety aspects of the various techniques in terms of biodistribution, toxicity, and tumorigenicity. [Curr Osteoporos Rep] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSWVU Eye Institute Fellow Receives Research Grant Ezequiel Salido, M.D., Ph.D., a second-year post-doctoral fellow at the WVU Eye Institute, received a $65,000 grant from the Knights Templar Eye Foundations (KTEF), Inc., to study the matrix between the photoreceptor and retinal pigment epithelial cells at the back of the eye. [WVU Medicine] Press Release Anika Therapeutics, Inc. announced results from its CINGAL® 16-02 clinical trial, an active-comparator Phase III study being conducted to support U.S. registration. [Anika Therapeutics, Inc.] Press Release | |
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POLICY NEWSHundreds of U.S. Scientists Urge More Transparency in Animal Research Breaking with a history of reticence, nearly 600 scientists, students, and lab animal workers published a letter in USA Today that calls on U.S. research institutions to “embrace openness” about their animal research. [ScienceInsider] Editorial U.S. Legislators Back Larger Facilities Budget for NSF The National Science Foundation (NSF) in Alexandria, Virginia, is in line for a budget increase of 4% to 5% next year. That assessment is based on bills approved recently by the spending committees in both chambers of Congress. Lawmakers have also signaled support for growing the account that NSF uses to build major new scientific facilities. [ScienceInsider] Editorial Why the Medical Research Grant System Could Be Costing Us Great Ideas The medical research grant system in the United States, run through the National Institutes of Health, is intended to fund work that spurs innovation and fosters research careers. In many ways, it may be failing. [The New York Times] Editorial
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EVENTSNEW Gordon Research Seminar: Biomaterials and Tissue Engineering Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Stem Cell and Regenerative Medicine (NYU Langone Medical Center) Research Associate – Regenerative Medicine (University of Bristol) Director – Davis Center for Regenerative Biology and Medicine (MDI Biological Laboratory) Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego) Full Professor – Biomedical Sciences (Dublin City University) Postdoctoral Fellow – Bioengineering (Harvard University) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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