Hematopoiesis News Volume 4.32 | Aug 20 2013

Wnt5a Regulates Hematopoietic Stem Cell Proliferation and Repopulation Through the Ryk Receptor
The authors tested the hypothesis that the Ryk protein, a Wnt ligand receptor that can bind the Wnt5a ligand, regulated the response of hematopoietic stem cells (HSCs) to Wnt5a. They observed that inhibiting Ryk blocked the ability of Wnt5a to induce HSC quiescence and enhance short-term and long-term hematopoietic repopulation. [Stem Cells] Abstract

Characteristic Phenotypes Associated with Congenital Dyserythropoietic Anemia (Type II) Manifest at Different Stages of Erythropoiesis
Scientists employed an in vitro culture system to monitor the appearance of the defining phenotypes associated with Congenital Dyserythropoietic Anemia Type II during terminal differentiation of erythroblasts derived from small volumes of patient peripheral blood. [Haematologica] Abstract | Full Article

CD137 Ligand Reverse Signaling Skews Hematopoiesis towards Myelopoiesis during Aging
CD137L is expressed on the surface of hematopoietic progenitor cells, and upon binding to CD137 induces reverse signaling into hematopoietic progenitor cells promoting their activation, proliferation and myeloid differentiation. Since aging is associated with an increasing number of myeloid cells researchers investigated the role of CD137 and CD137L on myelopoiesis during aging. [Aging] Full Article

Utilization of TREC and KREC Quantification for the Monitoring of Early T- and B-Cell Neogenesis in Adult Patients after Allogeneic Hematopoietic Stem Cell Transplantation
Scientists examined whether quantification of T cell receptor excision circle, (TREC) and kappa-deleting recombination excision circle (KREC) before and within six months after allogeneic hematopoietic stem cell transplantation could be used to measure the thymic and bone marrow outputs in such patients. [J Transl Med] Full Article

CLINICAL RESEARCH

Trends in Utilization and Outcomes of Autologous Transplantation as Early Therapy for Multiple Myeloma
Scientists reviewed characteristics and outcomes of 20,278 patients undergoing autologous hematopoietic progenitor cell transplantation within 12 months of multiple myeloma diagnosis in the US and Canada and registered at the Center for International Blood and Marrow Transplant Research in three time cohorts: 1995-1999, 2000-2004 and 2005-2010, reflecting increasing availability of novel drugs. [Biol Blood Marrow Transplant] Abstract

Addition of Plerixafor for CD34+ Cell Mobilization in Six Healthy Stem Cell Donors Ensured Satisfactory Grafts for Transplantation
The authors present six cases in which the “just-in-time” addition of plerixafor ensured proper CD34+ collection from healthy donors with insufficient granulocyte-colony-stimulating factor mobilization. In four of these cases a high number of CD34+ cells was needed due to subsequent CD34+ selection or haploidentical transplantation. [Transfusion] Abstract

Intensive Induction Chemotherapy Followed by Myeloablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue for Young Children Newly-Diagnosed with Central Nervous System Atypical Teratoid/Rhabdoid Tumors: The Head Start III Experience
Nineteen children with newly diagnosed central nervous system atypical teratoid/rhabdoid tumor were treated on the head start III protocol. Treatment consisted of surgical resection, five cycles of induction chemotherapy, followed by consolidation with myeloablative chemotherapy and autologous hematopoietic progenitor cell rescue. [Pediatr Blood Cancer] Abstract

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Stem Cell Research Lab to Open at Tehnopol
A stem cell research lab was opened at Tehnopol, a science park in Tallinn. In cooperation with the Cell Therapy Cluster, the Enterprise Estonia and EU-funded lab will be used to develop high-quality cell treatment products. [Estonian Public Broadcasting] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the hematopoiesis research community.

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate – Stem Cell and Leukemia Epigenetics (King’s College London)

Postdoctoral Position – Hematopoietic Stem Cells (St. Jude Children’s Research Hospital)

Postdoctoral Position – Hematopoiesis (Lund Stem Cell Center)

Postdoctoral Research Associates – Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Fellow – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Tenure-Track Position – Cell Biologist (McGill University)

Postdoctoral Appointee – Cell Cycle Regulation in Tumor Stem Cells (Rutgers University, Rutgers Cancer Institute of New Jersey)

Postdoctoral Position – Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Fellow – Cancer Stem Cell Biology (McGill University)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)

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