Hematopoiesis News Volume 3.04 | Jan 30 2012

LABORATORY RESEARCH

HIF1α Is Required for Survival Maintenance of Chronic Myeloid Leukemia Stem Cells
Using a mouse model of chronic myeloid leukemia, here researchers report that hypoxia-inducible factor-1α (HIF1α) plays a crucial role in survival maintenance of leukemia stem cells. [Blood] Abstract

Angiotensin-Converting Enzyme Specifies Emerging Lympho-Hematopoietic Progenitors in the Human Embryo
Researchers’ data suggest that, in addition to being a marker of adult human hematopoietic stem cells (HSC), angiotensin converting enzyme identifies embryonic mesodermal precursors responsible for definitive hematopoiesis, and they propose that this enzyme is involved in the regulation of human blood formation. [Blood] Abstract

Membrane-Bound Human SCF/KL Promotes In Vivo Human Hematopoietic Engraftment and Myeloid Differentiation
Limited human hematopoietic stem cell function may partially be attributed to the inability of the host mouse microenvironment to provide sufficient support to human hematopoiesis. To address this problem, researchers created membrane-bound human stem cell factor (SCF)/KIT ligand (KL)-expressing NOD/SCID/IL2rgKO mice. [Blood] Abstract

The Significance of Integrin Ligand Nanopatterning on Lipid Raft Clustering in Hematopoietic Stem Cells
To investigate the impact of nanometer-scale spacing between cell ligands on hematopoietic stem cell adhesion, integrin distribution and signal transduction, researchers employed geometrically defined, nanostructured, bio-functionalized surfaces. [Biomaterials] Abstract

Telomere Dysfunctional Environment Induces Loss of Quiescence and Inherent Impairments of Hematopoietic Stem Cell Function
This study shows that the telomere dysfunctional environment leads to irreversible impairments in the repopulation capacity of wildtype hematopoietic stem cells. [Aging Cell] Abstract

ETV6–PDGFRB and FIP1L1–PDGFRA Stimulate Human Hematopoietic Progenitor Proliferation and Differentiation into Eosinophils: Role of NF-κB
The aim of this work was to gain insight into the mechanisms whereby fusion genes affect human hematopoietic cells and in particular the eosinophil lineage. [Haematologica] Abstract

MicroRNA126 Contributes to G-CSF-Induced Hematopoietic Progenitor Cell Mobilization by Reducing VCAM-1 Expression
Researchers analyzed phenotypic, biochemical and genetic changes in bone marrow cell populations from G-CSF mobilized and control mice, and linked such changes to effective mobilization of hematopoietic stem/progenitor cells. [Haematologica] Abstract

Single-Cell Analysis of Murine Long-Term Hematopoietic Stem Cells Reveals Distinct Patterns of Gene Expression during Fetal Migration
The aim of this study was to characterize the expression of migration related genes in fetal long-term hematopoietic stem cells across different anatomical locations during development. [PLoS One] Abstract

CLINICAL RESEARCH

Clofarabine Plus Low-Dose Cytarabine followed by Clofarabine Plus Low-Dose Cytarabine Alternating with Decitabine in Acute Myeloid Leukemia Frontline Therapy for Older Patients
In this study, the authors have designed a combination of clofarabine plus low-dose cytarabine followed by a prolonged consolidation alternating with decitabine. [Cancer] Abstract

Evaluation of Minimal Residual Disease by Real-Time Quantitative PCR of Wilms´ Tumor 1 (WT1) Expression in Patients with Acute Myeloid Leukemia after Allogeneic Stem Cell Transplantation – Correlation with Flow Cytometry and Chimerism
The aim of this study was to evaluate the usefulness of WT1 expression in acute myeloid leukemia patients after stem cell transplantation as a relapse predictor marker, and compare it with that of flow cytometry and chimerism studies. [Biol Blood Marrow Transplant] Abstract

Celator^® Pharmaceuticals Receives European Medicines Agency Orphan Drug Status for CPX-351 in Acute Myeloid Leukemia
Celator Pharmaceuticals announced that the European Commission has granted orphan drug status to CPX-351, the company’s proprietary “liposomal combination of cytarabine and daunorubicin,” for the treatment of acute myeloid leukemia. [Celator Pharmaceuticals] Press Release

Pfizer Announces FDA Acceptance of New Drug Application for Bosutinib for Patients with Previously Treated Ph+ Chronic Myeloid Leukemia
Pfizer Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application for standard review of bosutinib as a treatment option for adult patients with previously treated Philadelphia chromosome positive (Ph+) chronic myeloid leukemia. [Business Wire] Press Release

Formula Pharmaceuticals Appoints Martyn Greenacre to Board of Directors
Formula Pharmaceuticals announced the appointment of Martyn Greenacre to the Board of Directors. [Formula Pharmaceuticals] Press Release

Celgene to Acquire Avila Therapeutics
Celgene Corporation and Avila Therapeutics, Inc. announced a definitive merger agreement under which Celgene Corporation will acquire Avila Therapeutics, Inc. The acquisition positions Celgene to expand its leading role in the future treatment of hematologic cancers with Avila’s AVL-292 currently in phase I clinical development. [Avila Therapeutics, Inc.] Press Release

Blood Products Advisory Committee; Notice of Meeting (FR Doc No: 2012-1888) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)
 
Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 2012 Molecular Medicine Tri-Conference: Targeting Cancer Stem Cells in Oncology Symposium
February 19-23, 2012
San Francisco, United States

Visit our events page to see a complete list of events in the hematopoietic community

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Researchers (Centre for Cancer Biology)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Postdoctoral Positions in Stem Cell Biology (Columbia University)

Professorship in Hematopoietic Stem Cell Transplantation and Head (University of Göttingen)

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