LABORATORY RESEARCH The miR-144/451eGFP Allele, a Novel Tool for Resolving the Erythroid Potential of Hematopoietic Precursors Scientists presented a novel eGFP allele that allows the quantitative analysis of red blood cell origin at the single-cell level. [Blood] Transgenic Expression of Human Signal Regulatory Protein Alpha in Rag2−/−γc−/− Mice Improves Engraftment of Human Hematopoietic Cells in Humanized Mice Researchers have generated mice that faithfully express a transgene of human signal regulatory protein alpha, a receptor that negatively regulates phagocytosis, in Rag2−/−γc−/− mice on a mixed 129/BALB/c background. [Proc Natl Acad Sci U S A] Conditioning for Hematopoietic Transplantation Activates the Complement Cascade and Induces a Proteolytic Environment in Bone Marrow: A Novel Role for Bioactive Lipids and Soluble C5b-C9 as Homing Factors Investigators have observed that conditioning for hematopoietic transplantation by lethal irradiation induces a proteolytic microenvironment in the bone marrow that activates the complement cascade. [Leukemia] BCL-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Therapeutic Response In this study, researchers report findings derived from a pool-based shRNA assay that systematically and comprehensively interrogated the functional dependence of leukemia and lymphoma cells upon various BCL-2 family members across many diverse in vitro and in vivo settings. [Cancer Res] Zebrafish Mll Is Essential for Hematopoiesis Here, scientists investigated the role of mixed lineage leukemia (Mll) during zebrafish embryogenesis, in particular, hematopoiesis. [J Biol Chem] The Transcription Factor Mxd4 Controls the Proliferation of the First Blood Precursors at the Onset of Hematopoietic Development In Vitro Researchers show that Mxd4 expression is transiently down-regulated at an early stage of commitment to the hematopoietic lineage. [Exp Hematol] CLINICAL RESEARCH ABVD Versus BEACOPP for Hodgkin’s Lymphoma When High-Dose Salvage Is Planned Treatment with BEACOPP, as compared with the combination of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), resulted in better initial tumor control, but the long-term clinical outcome did not differ significantly between the two regimens. [N Engl J Med] Variants at 6q21 Implicate PRDM1 in the Etiology of Therapy-Induced Second Malignancies After Hodgkin’s Lymphoma Scientists identified two variants at chromosome 6q21 associated with second malignant neoplasms in survivors of Hodgkin’s lymphoma treated with radiation therapy as children but not as adults. [Nat Med] Outcome of High-Risk Myelodysplastic Syndrome After Azacitidine Treatment Failure 435 patients with high-risk myelodysplastic syndrome and former refractory anemia with excess blasts in transformation were evaluated for outcome after azacitidine failure. [J Clin Oncol] A Phase Ib Study of Vosaroxin, an Anticancer Quinolone Derivative, in Patients with Relapsed or Refractory Acute Leukemia This study of vosaroxin evaluated dose-limiting toxicity, maximum-tolerated dose, pharmacokinetics, clinical activity and pharmacodynamics in relapsed/refractory leukemia. [Leukemia] Long-term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy and Transplantation of Purified Autologous Hematopoietic Stem Cells Investigators present the long-term outcome of a pilot study determining feasibility and engraftment using high-dose chemotherapy and purified hematopoietic stem cells in patients with metastatic breast cancer. [Biol Blood Marrow Transplant] |