| CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH Major Histocompatibility Complex Class II Transactivator CIITA Is a Recurrent Gene Fusion Partner in Lymphoid Cancers Here scientists show a highly expressed gene fusion involving the major histocompatibility complex class II transactivator CIITA (MHC2TA) in KM-H2 cells. [Nature] CXCL1 and its Receptor, CXCR2, Mediate Murine Sickle Cell Vaso-Occlusion during Hemolytic Transfusion Reactions Researchers established a model of alloimmune, IgG-mediated hemolytic transfusion reactions in a well-characterized humanized murine model of sickle cell disease. [J Clin Invest] Predicting Clonal Self-Renewal and Extinction of Hematopoietic Stem Cells Investigators used an interdisciplinary approach, combining transplantation assays with mathematical and computational methods, to systematically analyze the proliferative potential of individual hematopoietic stem cells. [Proc Natl Acad Sci U S A] Jagged2 Acts as a Delta-Like Notch Ligand During Early Hematopoietic Cell Fate Decisions Results reveal a unique role for Jagged1 in preventing the induction of T-lineage differentiation in hematopoietic stem cells and show an unexpected functional similarity between Jagged2 and the Delta-like ligands. [Blood] The c-Myb Target Gene Neuromedin U Functions as a Novel Cofactor During the Early Stages of Erythropoiesis Data strongly support that the c-Myb target gene neuromedin U functions as a novel cofactor for erythropoiesis and expands early erythroblasts. [Blood] miR-34a Induces the Down-Regulation of Both E2F1 and B-Myb Oncogenes in Leukemic Cells The purpose of the study is to elucidate new molecular mechanisms able to down-regulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective. [Clin Cancer Res] Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Is Dependent on Ca2+ Influx through Plasma Membrane Ca2+ Channels Results indicate tipifarnib causes cell death via a novel mechanism involving activation of a plasma membrane Ca2+ channel and intracellular Ca2+ overload. [J Pharmacol Exp Ther] Hodgkin Lymphoma Risk: Role of Genetic Polymorphisms and Gene-Gene Interactions in DNA Repair Pathways Researchers hypothesized that gene-gene interaction between candidate genes in direct reversal, nucleotide excision repair, base excision repair and double strand break pathways may contribute to susceptibility to Hodgkin lymphoma. [Mol Carcinog] YBX1 Expression and Function in Early Hematopoiesis and Leukemic Cells Here, scientists show that Y-box protein (YBX1) is highly expressed in mouse erythroid myeloid lymphoid-clone 1 (EML) but is down-regulated in myeloid progenitors and GM-CSF-treated EML cells during the course of myeloid differentiation. [Immunogenetics] CLINICAL RESEARCH NKp46 Identifies an NKT Cell Subset Susceptible to Leukemic Transformation in Mouse and Human Researchers show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. [J Clin Invest] Myelodysplasia and Leukemia of Fanconi Anemia Are Associated with a Specific Pattern of Genomic Abnormalities that Includes Cryptic RUNX1/AML1 Lesions Data have implications for staging and therapeutic managing in Fanconi anemia patients, and also to analyze the mechanisms of clonal evolution and oncogenesis in a background of genomic instability and bone marrow failure. [Blood] |
| EVENTS | NEW 20th Annual American Association for Cancer Research Aspen Workshop: Molecular Biology in Clinical Oncology July 16-22, 2011 Snowmass, United States NEW European School of Haematology Workshop: Leukemic and Cancer Stem Cells April 29-May 1, 2011 Mandelieu, France NEW European School of Haematology – International Chronic Myeloid Leukemia Foundation 12th International Conference: Chronic Myeloid Leukaemia – Biological Basis of Therapy September 24-26, 2011 Washington, United States NEW European School of Hematology – European Hematology Association Scientific Workshop: ACUTE MYELOID LEUKEMIA “MOLECULAR” October 14-16, 2011 Madndelieu, France NEW International Society on Thrombosis & Hemostasis – European School of Hematology: Advanced Course in Thrombosis & Hemostasis November 7-10, 2011 Cascais, Portugal Visit our events page to see a complete list of events in the hematopoietic community. |
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