CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Pharmacological Inhibition of EGFR Signaling Enhances G-CSF-Induced Hematopoietic Stem Cell Mobilization The findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provided a new pharmacological approach for improving hematopoietic stem and progenitor cell mobilization and thereby transplantation outcomes. [Nat Med] AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling Data show that CRTC2 inactivation, via physiologic DNA damage response signaling, promotes B cell differentiation in response to genotoxic stress. [Mol Cell] Notch Signaling is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease Here, researchers reported that Notch signaling is a potent regulator of T cell activation, differentiation and function during acute graft-versus-host disease. [Blood] Autocrine/Paracrine Cytokine Stimulation of Leukemic Cell Proliferation in Smoldering and Chronic Adult T Cell Leukemia Researchers demonstrated that smoldering/chronic adult T cell leukemia (ATL) PBMC spontaneously proliferated ex vivo in a cytokine (IL-2/IL-9/IL-15) dependent manner while acute type ATL PBMC did not proliferate or proliferated independent of cytokines. [Blood] High-Definition Mapping of Retroviral Integration Sites Identifies Active Regulatory Elements in Human Multipotent Hematopoietic Progenitors High-definition MLV integration maps provide a rational basis for predicting genotoxic risks in gene therapy, and a new tool for genome-wide identification of promoters and regulatory elements controlling hematopoietic stem and progenitor cell functions. [Blood] Ligation of Complement Receptor 1 Increases Erythrocyte Membrane Deformability Researchers show that ligation of red blood cell complement receptor 1 (RBC CR1) by antibody and complement-opsonized particles induces a transient Ca++ influx that is proportional to the RBC CR1 levels and is inhibited by T1E3 polyclonal antibody, a specific inhibitor of TRPC1 channels. [Blood] Adiponectin and Heme Oxygenase-1 Suppress TLR4/MyD88-Independent Signaling in Rat Kupffer Cells and in Mice after Chronic Ethanol Exposure Here, researchers investigated the interactions between chronic ethanol, adiponectin, and heme oxygenase-1 in regulation of TLR4/MyD88-independent signaling in macrophages and an in vivo mouse model. [J Immunol] CLINICAL RESEARCH Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia The objective of this study was to investigate the relationship between telomere length and clinical outcomes in severe aplastic anemia. [JAMA] Clinical and Genetic Features of Therapy-Related Myeloid Neoplasms after Chemotherapy for Acute Promyelocytic Leukemia Researchers attempted to clarify the different clinical features and hematological findings between therapy-related myeloid neoplasms (t-MN) and relapse cases, and to identify gene alterations involved in t-MN. [Blood] Reduced-Intensity Conditioning Significantly Improves Survival of Patients with Hemophagocytic Lymphohistiocytosis Undergoing Allogeneic Hematopoietic Cell Transplantation Researchers conclude that reduced-intensity conditioning significantly improves the outcome of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation. [Blood]
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POLICY NEWS NIH Releases Biennial Report of the Director Dr. Francis S. Collins, M.D., Ph.D, director of the National Institutes of Health, announced the release of the Biennial Report of the Director, NIH, for fiscal years 2008 and 2009. The report provides an integrated portrait of NIH research activities, making it easy for Congress, advocates and patient groups and the general public to understand the many activities of the agency. [National Institutes of Health, United States] The NCI Cancer Immunotherapy Trials Network (CITN) Seeks Member Clinical Sites (NOT-CA-10-034) [National Institutes of Health, United States] Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (PAR-10-286) [National Institutes of Health, United States] Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-23852) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-23847) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-23849) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23860) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23952) [National Institutes of Health, United States] National Cancer Institute; Notice of Meeting (FR Doc. 2010-23543) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-23545) [National Institutes of Health, United States]
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EVENTS (Listed by Date) Stem Cells and Regeneration – NIH Sponsored Advanced Training Courses October 3-9, 2010 Woods Hole, United States American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010 October 9-12, 2010 Baltimore, United States NEW National Marrow Donor Program (NMDP) 2010 Council Meeting October 15-17, 2010 Minneapolis, United States ‘HAA 2010’ – The Combined Annual Scientific Meeting of HSANZ, ANZSBT AND ASTH October 17-20, 2010 Auckland, New Zealand NEW 6th Modern Drug Discovery & Development Summit (M3D) October 20-22, 2010 San Francisco, United States NEW American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference October 21-22, 2010 Washington, DC, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany NEW 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States NEW 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany NEW 9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases November 17-19, 2010 Sonoma, United States 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Highlights of American Society of Hematology (ASH) Vancouver January 21-22, 2011 Vancouver, Canada Highlights of American Society of Hematology (ASH) Washington, DC and San Francisco January 28-29, 2011 Washington, DC and San Francisco, United States Highlights of American Society of Hematology (ASH) New York and San Diego February 4-5, 2011 New York and San Diego, United States NEW BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Hematopoiesis March 27-April 1, 2011 Big Sky, United States American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States 37th Annual Meeting of the European Group for Blood and Marrow Transplantation April 3-6, 2011 Paris, France International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES
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