VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow to Attenuate Tumor Growth Researchers employed a mouse model of spontaneous breast cancer to investigate the mechanism by which VEGF pathway inhibition alters hematopoiesis. [Cancer Res] Abstract | Full Article Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression within the Pre-Metastatic Niche Investigators showed that a distant primary tumor drives the expansion of hematopoietic stem and progenitor cells within the bone marrow and their mobilization to the bloodstream. [Cancer Res] Abstract Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis The authors found that the non-canonical PRC1.1 complex, as identified by mass-spectrometry-based proteomics, is critically important for human leukemic stem cells. [Cell Rep] Full Article | Graphical Abstract MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199 The authors showed that t(4;11) patient cells express high levels of BCL-2 and are highly sensitive to treatment with the BCL-2-specific BH3 mimetic ABT-199. [Cell Rep] Full Article | Graphical Abstract Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression Twist-1 over-expressing bone marrow-derived mesenchymal stem/stromal cells exhibited an enhanced capacity to maintain human CD34+ hematopoietic stem cells in long-term culture-initiating cell assays. [Stem Cells] Abstract Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment Scientists showed that, similar to adult hematopoietic stem cells (HSCs), fetal HSCs selectively fail to regenerate B-1a. [Stem Cell Reports] Full Article Role of Polycomb RYBP in Maintaining the B-1 to B-2 B-Cell Lineage Switch in Adult Hematopoiesis Researchers showed that a sustained regulation of B-1 to B-2 switch is needed throughout adult life and that RYBP plays an important role in keeping B-2 dominance, most likely independently of its Polycomb affiliation. [Mol Cell Biol] Abstract CLINICAL RESEARCH Autologous Hematopoietic Stem Cell Transplantation for Refractory Crohn Disease Among adult patients with refractory Crohn disease not amenable to surgery who had impaired quality of life, hematopoietic stem cell transplantation, compared with conventional therapy, did not result in a statistically significant improvement in sustained disease remission at one year and was associated with significant toxicity. [JAMA] Abstract | Press Release Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells Scientists investigated the impact of conditional hematopoietic Dnmt3a loss on disease phenotype in primary mice. Mx1-Cre-mediated Dnmt3a ablation led to the development of a lethal, fully penetrant myeloproliferative neoplasm with myelodysplasia characterized by peripheral cytopenias and by marked, progressive hepatomegaly. [Leukemia] Abstract |