The Kinase PKCα Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses Scientists identified protein kinase C α (PKCα) as a signaling intermediate specific to the T helper 17 (Th17) cell subset in the activation of TGFβ receptor I (TGFβRI). They showed that PKCα physically interacts and functionally cooperates with TGFβRI to promote robust SMAD2-3 activation. [Immunity] Full Article
Therapeutic Opportunities for Manipulating TReg Cells in Autoimmunity and Cancer The authors discuss insights into the generation of regulatory T (TReg) cells, their involvement in disease and the molecular basis of the dominant tolerance exerted by forkhead box P3-expressing TReg cells that could permit their safe and specific manipulation in humans. [Nat Rev Drug Discov] Abstract
INDUSTRY NEWS
Receptos Doses First Patient in Phase II Trial for RPC1063 in Ulcerative Colitis Receptos, Inc., announced that its selective sphingosine‐1‐ phosphate 1 receptor modulator, RPC1063, has been administered to the first patient in a phase II study examining the clinical efficacy and safety of induction therapy in patients with moderately to severely active ulcerative colitis. [PR Newswire Association LLC] Press Release
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