Immune Regulation News 3.33, September 9, 2011 |
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| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of Plasmodium falciparum sporozoite-specific CD8+, interferon-γ–producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). [Science] Abstract Human Cytomegalovirus MicroRNA miR-US4-1 Inhibits CD8+ T Cell Responses by Targeting the Aminopeptidase ERAP1 The findings identify a previously unknown viral microRNA–based cytotoxic T lymphocyte-evasion mechanism that targets a key step in the major histocompatibility complex class I antigen-processing pathway. [Nat Immunol] Abstract The Helicase DDX41 Senses Intracellular DNA Mediated by the Adaptor STING in Dendritic Cells Here investigators report the identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells. [Nat Immunol] Abstract Invariant Natural Killer T Cells Recognize Glycolipids from Pathogenic Gram-Positive Bacteria Here researchers show that natural killer T cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae and group B Streptococcus. [Nat Immunol] Abstract A Recombinant Mycobacterium smegmatis Induces Potent Bactericidal Immunity Against Mycobacterium tuberculosis Analysis of the adaptive immune responses indicated that the highly protective bactericidal immunity elicited by IKEPLUS was dependent on CD4+ memory T cells and involved a distinct shift in the pattern of cytokine responses by CD4+ cells. [Nat Med] Abstract | Press Release Increased Sensitivity of Antigen-Experienced T Cells Through the Enrichment of Oligomeric T Cell Receptor Complexes Through biochemistry and electron microscopy, researchers showed that previously stimulated and memory T cells have more and larger T cell receptor oligomers at the cell surface than their naive counterparts. [Immunity] Abstract Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production To systematically investigate innate immune signaling networks regulating production of type I interferon, researchers analyzed protein complexes formed after microbial recognition. [Immunity] Abstract Protective Antiviral Antibody Responses in a Mouse Model of Influenza Virus Infection Require TACI Here, researchers have identified a critical role for extrinsic cytokine signals in the survival of respiratory tract antibody-secreting cells in a mouse model of influenza infection. [J Clin Invest] Abstract | Press Release The Cyclin Dependent Kinase Inhibitor p21 Is Essential for Resolution of Murine Inflammatory Arthritis via its C-Terminal Domain Here, investigators sought to determine the role and mechanism of p21-mediated suppression of experimental inflammatory arthritis. [Arthritis Rheum] Abstract | Press Release Natural Killer Cells in Free-Living Mus musculus Have a Primed Phenotype The findings indicate a high degree of pre-activation of natural killer (NK) cells of free-living mice, indicating a strong environmental impact on NK cells, which may be highly relevant for interpretation of studies in the mouse model. [Mol Ecol] Abstract | Press Release |
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