Immune Regulation News Volume 2.38 | Oct 8 2010

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    Immune Regulation News 2.38, October 8, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Mice With Human Body’s Defences  ShareThis
    Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore.  However, antibodies obtained from blood of animals such as mice could not be used because the human immune system recognizes them as foreign and rejects them. With the help of human stem cells, researchers generated mice with a human immune system, which were then vaccinated to produce human monoclonal antibodies. [Press release from the Helmholtz Centre for Infection Research discussing online prepublication in PLoS ONE]

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    SPECIAL FEATURE

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    SCIENCE NEWS

    OHSU Primate Center Research Reveals Possible Method for Boosting the Immune System To Protect Infants Against HIV
    Researchers at Oregon Health & Science University may have uncovered a new weapon for combating HIV as it is passed from mother to newborn child. [Press release from the Oregon Health & Science University discussing online prepublication in Nature Medicine]

    Vaccine Extends Glioblastoma Patients’ Survival in Phase II Trial
    A vaccine that turns the immune system against brain tumor cells bearing a genetic mutation that drives the most aggressive form of glioblastoma multiforme improved survival of patients in a phase II clinical trial, researchers reported. [Press release from the MD Anderson Cancer Center discussing online prepublication in the Journal of Clinical Oncology]

    T Cell Discovery Shows Promise for Type I Diabetes Treatment: UBC-CFRI Study
    A research team has identified the role of a type of T cell in type I diabetes that may lead to new treatment options for young patients. [Press release from the University of British Columbia discussing online prepublication in the Journal of Immunology]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Passive Neutralizing Antibody Controls SHIV Viremia and Enhances B Cell Responses in Infant Macaques
    The studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings. [Nat Med]

    Invariant NKT Cells Modulate the Suppressive Activity of IL-10-Secreting Neutrophils Differentiated with Serum Amyloid A
    Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. Researchers now show that systemic serum amyloid A 1 controls the plasticity of neutrophil differentiation. [Nat Immunol]

    Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling
    Researchers report that mammalian target of rapamycin (mTOR) inhibitor rapamycin impaired Flt3L-driven dendritic cell (DC) development in vitro, with the plasmacytoid DCs and CD8+-like classical DCs most profoundly affected. [Immunity]

    Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma
    Epidermal growth factor receptor variant III-targeted vaccination in patients with glioblastoma multiforme warrants investigation in a phase III, randomized trial. [J Clin Oncol]

    Stimulation and Inhibition of FVIII-Specific Memory-B Cell Responses by CpG-B (ODN 1826), A Ligand for Toll-Like Receptor 9
    Researchers asked how stimulation and inhibition of Factor VIII (FVIII)-specific memory B cells by low and high concentrations of FVIII, respectively, are affected by concurrent activation of the innate immune system. [Blood]

    Interferon Gamma Limits the Effectiveness of Melanoma Peptide Vaccines
    The results demonstrate that peptide vaccines can eradicate large established tumors in circumstances where the inhibitory activities of interferon gamma are curtailed. [Blood]

    Relevance of the Mevalonate Biosynthetic Pathway in the Regulation of Bone Marrow Mesenchymal Stromal Cell-Mediated Effects on T Cell Proliferation and B Cell Survival
    Herein, researchers defined the effects of cholesterol synthesis inhibitors on the interaction between these mesenchymal stromal cells and T or B lymphocytes. [Haematologica]

    Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation
    The aim of this work was to elucidate the immunogenic effects of bone marrow mesenchymal stem cell/dendritic cell (DC) interactions during DC activation (LPS stimulation or Ag loading). [J Immunol]

    Cellular Requirements for Diabetes Induction in DO11.10xRIPmOVA Mice
    The results help define the events leading to diabetes in DO11.10xRIPmOVA mice and provide new insights into the cellular interactions required for disease development in an antigen-specific model of type I diabetes. [ J Immunol]

    Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice
    In this work, researchers describe a novel approach to generate fully human monoclonal antibodies by combining a humanized mouse model with a new B cell immortalization technique. [PLoS ONE]

    INDUSTRY NEWS

    Juvaris BioTherapeutics Announces Publication of Preclinical Anti-Leukemic Effects of JVRS-100 Immunotherapy
    Juvaris BioTherapeutics, Inc. announced that results from preclinical studies using its lead compound, JVRS-100, as an immunotherapy to treat acute myelogenous leukemia were published. [Juvaris BioTherapeutics, Inc. Press Release]

    Immunovaccine and IRX Therapeutics Collaborate on Cancer Immunotherapies
    Immunovaccine Inc. and IRX Therapeutics, announced that the two companies have entered into a preclinical research collaboration to evaluate the combination of IRX’s primary cell-derived biologic, IRX-2, and DepoVax(TM)- based therapeutic cancer vaccines. [Immunovaccine Inc. Press Release]


    POLICY NEWS

    NIH Grants Will Advance Studies of the Form and Function of Proteins
    The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. [National Institutes of Health, United States]

    NCBI Launches the Database of Genomic Structural Variations
    The National Institutes of Health announced the launch of a new resource, called the Database of Genomic Structural Variation, or dbVar, to help scientists understand how differences in DNA contribute to human health and disease. [National Institutes of Health, United States]

    Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
    U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

    NIH and FDA Announce Awards to Advance Regulatory Science
    The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health, United States]

    Tumor Microenvironment Network (TMEN) (U54) (RFA-CA-10-021) [Department of Health and Human Services, United States]

    Resource Related Research Projects for Development of Animal Models and Related Materials (R24) (PAR-10-289) [National Center for Research Resources, United States]

    Animal and Biological Material Resource Centers (P40) (PAR-11-001) [National Center for Research Resources, United States]

    NHLBI Translational Research Implementation Program (TRIP) – Limited Competition – (P50) (RFA-HL-12-003) [National Heart, Lung, and Blood Institute, United States]

    Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-24548) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24680) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24549) [National Institutes of Health, United States]



    EVENTS (Listed by Date)

    5th International Conference on Gene Regulation in Lymphocyte Development
    October 9-14, 2010
    Chania, Greece

    The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
    November 7-10, 2010
    Singapore

    2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
    November 11-16, 2010
    Phoenix, United States

    39th Autumn Immunology Conference
    November 19-22, 2010
    Chicago, United States

    Cell Symposia: Influenza – Translating Basic Insights
    December 2-4, 2010
    Washington, D.C., United States

    The 50th Midwinter Conference of Immunologists at Asilomar
    January 22-25, 2011
    Pacific Grove, United States

    Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
    January 24-26, 2011
    Washington, DC, United States

    Phacilitate 9th Annual North American Vaccine Forum
    January 24-26, 2011
    Washington, DC, United States

    Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
    February 12-17, 2011
    Santa Fe, United States

    Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
    February 15-20, 2011
    Taos, United States

    BMT Tandem Meetings (ASBMT/CIBMTR)
    February 17-21, 2011
    Honolulu, Hawaii

    18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
    February 27-March 2, 2011
    Boston, United States

    The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
    March 16-19, 2011
    Las Vegas, United States

    2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
    March 18-22, 2011
    San Francisco, United States

    Microbiota and Mucosal Immunology: The Interface in Health and Disease
    April 14-16, 2011
    San Francisco, United States

    GTCbio: 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
    May 2-5, 2011
    Budapest, Hungary

    American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
    May 18-22, 2011
    Seattle, United States

    Gordon Research Conference: Viruses & Cells
    May 29-June 3, 2011
    Lucca (Barga), Italy

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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