INTESTINAL CANCERS & DISEASES Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells from Patients with Crohn’s Disease Researchers investigated the profile of polyunsaturated fatty acid metabolites produced by enteric glial cells from rats and from patients with Crohn’s disease, compared with controls, along with the ability of one of these metabolites, 15-hydroxyeicosatetraenoic acid (15-HETE), to regulate the permeability of the intestinal epithelial barrier. [Gastroenterology] Abstract Atypical Role of Sprouty in Colorectal Cancer: Sprouty Repression Inhibits Epithelial–Mesenchymal Transition Scientists investigated the mechanisms by which Sprouty regulates epithelial–mesenchymal transition in colorectal cancer. [Oncogene] Full Article Tumor-Selective Proteotoxicity of Verteporfin Inhibits Colon Cancer Progression Independently of YAP1 The authors found that verteporfin inhibited tumor growth independently of its effects on Yes-associated protein 1 (YAP1) or the related protein TAZ in genetically or chemically induced mouse models of colorectal cancer (CRC), in patient-derived xenografts, and in enteroid models of CRC. [Sci Signal] Abstract Epigenetic Changes and Alternate Promoter Usage by Human Colon Cancers for Expressing DCLK1-Isoforms: Clinical Implications The authors report that the majority of human colon adenocarcinomas express short-transcripts of DCLK1 from an alternate β-promoter in IntronV of the gene, while normal-colons mainly express DCLK1-L from 5′(α)-promoter. [Sci Rep] Full Article GPR55 Promotes Migration and Adhesion of Colon Cancer Cells Indicating a Role in Metastasis Scientists investigated the involvement of G protein-coupled receptor 55 (GPR55) in migration and metastasis of colon cancer cells. [Br J Pharmacol] Abstract Mechanisms of DRA Recycling in Intestinal Epithelial Cells: Effect of Enteropathogenic E. Coli The authors investigated SLC26A3 (DRA) trafficking under basal conditions and in response to EPEC utilizing Caco-2 cells. [Am J Physiol Cell Physiol] Abstract Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice Researchers studied the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells and on mice tissues to decipher the underlying mechanisms. [PLoS One] Full Article Esculetin Induces Apoptosis in Human Colon Cancer Cells by Inducing Endoplasmic Reticulum Stress Investigators examined whether esculetin induces apoptosis in HT-29 colon cancer cells by inducing endoplasmic reticulum (ER) stress. They found that esculetin induced characteristic signs of ER stress, confirmed by ER staining, mitochondrial calcium overload and expression of ER stress-related proteins. [Cell Biochem Funct] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH Rapamycin Preserves Gut Homeostasis during Drosophila Aging Researchers demonstrated that rapamycin can slow down the proliferation rate of intestinal stem cells in the aging guts and induce autophagy in the intestinal epithelium in Drosophila. [Oncotarget] Full Article |