Intestinal Cell News 2.31 August 26, 2016 | |
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TOP STORYThe authors generated isogenic dyskeratosis congenita patient and disease allele-corrected intestinal tissue using clustered regularly interspaced short palindromic repeats/Cas9-mediated gene correction in induced pluripotent stem cells and directed differentiation. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)INTESTINAL CANCERS & DISEASESTNIK Inhibition Abrogates Colorectal Cancer Stemness Scientists report the first orally available small-molecule Traf2- and Nck-interacting kinase (TNIK) inhibitor, NCB-0846, having anti-Wnt activity. NCB-0846 suppresses Wnt-driven intestinal tumorigenesis in Apcmin/+ mice and the sphere- and tumor-forming activities of colorectal cancer cells. [Nat Commun] Full Article Energy Metabolism in Intestinal Epithelial Cells during Maturation along the Crypt-Villus Axis Investigators tested the hypothesis that the energy metabolism in intestinal epithelial cells would be changed during maturation along crypt-villus axis in neonates. [Sci Rep] Full Article Scientists investigated long-term effects of 56Fe radiation on adipokines and insulin-like growth factor 1 (IGF1) signaling axis in mouse intestine and colon. [Sci Rep] Full Article Proliferation and spatial development of colonic epithelial cells are highly regulated along the crypt vertical axis, which, when perturbed, can result in aberrant growth and carcinogenesis. Two key factors were identified that have important and counterbalancing roles regulating these processes: pericrypt myofibroblast-derived Wnt-5a and the microbial metabolite butyrate. [Sci Rep] Full Article Investigators observed that overexpression of Rab27A increased sphere formation efficiency by increasing the proportion of CD44+ and PKH26high cells in HT29 cell lines, and accelerating the growth of colosphere with a higher percentage of cells at S phase. [Oncotarget] Full Article Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis Scientists showed that ablation of Csk, a negative regulator of Src family kinases, specifically in intestinal epithelial cells resulted in the development of hyperplasia throughout the intestinal epithelium of mice. [Mol Cell Biol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCHScientists investigated the effect of cell division pattern along the crypt on mutant production, assuming that the division rate of each cell depends on its location. [Biol Direct] Full Article Murine Colonic Organoid Culture System and Downstream Assay Applications Researchers describe detailed protocols for mouse colonic crypt isolation, organoid culture, and downstream applications. Specific culture strategies including growth factor enriched Matrigel and Wnt and R-spondin conditioned media serve as key factors for enhancing the growth and cost efficiency of colonic organoid cultures. [Methods Mol Biol] Abstract | |
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REVIEWSThe authors focus mainly on the formation of the adult intestine during Xenopus metamorphosis. They discuss the role of thyroid hormone signaling pathway in the process and potential molecular conservations between amphibians and mammals as well as the implications in organ homeostasis and human diseases. [Rev Endocr Metab Disord] Abstract Visit our reviews page to see a complete list of reviews in the intestinal cell research field. | |
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INDUSTRY NEWS$27-Million Medicine by Design Investment Will Fast-Track Stem Cell Research David McMillen and his team are hard at work designing a new custom-designed probiotic to help the 233,000 Canadians living with Crohn’s and colitis. The goal of the project, which is among 20 sharing $27 million in funding from university’s newly created Medicine by Design initiative, is to create a bacterium that can help trigger the renewal of the gut lining in people with these chronic bowel diseases. [University of Toronto] Press Release CPRIT Awards $9.6 Million for UTSW Projects in Cancer Treatments, Screening, and Genetics Research Six new cancer research projects involving treatment, prevention, outreach, and genetics recently received a total of $9.6 million in support from the Cancer Prevention and Research Institute of Texas (CPRIT). [The University of Texas Southwestern Medical Center] Press Release Lycera Corp. announced the initiation of a Phase II clinical trial of the company’s lead clinical-stage candidate, LYC-30937-Enteric Coated, in patients with ulcerative colitis. [Lycera Corp.] Press Release | |
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POLICY NEWSObama’s Science Legacy: Uneven Progress on Scientific Integrity Many researchers who watched Barack Obama’s inauguration in 2009 were thrilled by his pledge to “restore science to its rightful place”. But scientists and legal scholars say that, in many ways, Obama has failed to live up to that lofty promise. [Nature News] Editorial New Leader of NIH’s Research Watchdog Faces Staff Revolt The Office of Research Integrity (ORI) in Rockville, Maryland, which guards against misconduct in biomedical research, usually attracts attention with its findings, not its internal workings. But two years ago, its director, David Wright, quit in a public huff, complaining that ORI was hobbled by a dysfunctional federal bureaucracy. Now, his successor is encountering her own rough waters. [Nature News] Editorial Putin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial
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EVENTSNEW 2016 World Cancer Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Specialist – Digestion/Motility (Nestle Institute of Health Sciences) NEW Postdoctoral Research Fellow – Cancer Epidemiology (Fred Hutchinson Cancer Research Center) Technical Sales Representative (STEMCELL Technologies Inc.) PhD Student – Intestinal Epithelial Cell Death and Barrier Function (University of East Anglia) Postdoctoral Fellow or PhD Student – Gastrointestinal Cancers (Goethe University Frankfurt) Senior Scientist – Human Microbiome (Nestle Institute of Health Sciences) Postdoctoral Position – Mucosal Immunology (KU Leuven) Postdoctoral Researcher – Colon Cancer (German Cancer Research Center) Assistant or Associate Member – Stem CellGene Therapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Intestinal Cell News Volume 2.31 | Aug 26 2016