| TOP STORY | Immune Protein Could Stop Diabetes in Its Tracks Researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed. [Press release from the Walter and Eliza Hall Institute of Medical Research discussing online prepublication in Nature Immunology] Press Release | Abstract | Video |
| REVIEWS | The Good, the Bad and the Ugly – TFH Cells in Human Health and Disease Long-lived humoral immunity depends on help provided by CD4+ T cells, namely T follicular helper (TFH) cells, which support the differentiation of antigen-specific B cells into memory and plasma cells. TFH cells are stringently regulated, as aberrant TFH cell activity is involved in immunopathologies such as autoimmunity, immunodeficiencies and lymphomas. The elucidation of the mechanisms that regulate TFH cell differentiation, function and fate should highlight targets for novel therapeutics. [Nat Rev Immunol] Abstract The BAFF/A Proliferation Inducing Ligand System: Emerging Functions beyond B Cell Biology and Autoimmunity The authors provide the latest views on additional roles of the B cell activating factor from the tumor necrosis factor family (BAFF) system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials. [Cytokine Growth Factor Rev] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. |
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