Remote Control of Therapeutic T Cells through a Small Molecule–Gated Chimeric Receptor Investigators present the design of “ON-switch” chimeric antigen receptors that enable small molecule-control over T cell therapeutic functions, while still retaining antigen specificity. This titratable pharmacologic regulation could allow physicians to precisely control the timing, location, and dosage of T cell activity, thereby mitigating toxicity. [Science] Abstract | Press Release | Video Glycolysis Controls the Induction of Human Regulatory T Cells by Modulating the Expression of FOXP3 Exon 2 Splicing Variants Researchers found that the induction and suppressive function of induced human regulatory T cells tightly depended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 through the glycolytic enzyme enolase-1. [Nat Immunol] Abstract Tumor PD-L1 Expression, Immune Cell Correlates and PD-1+ Lymphocytes in Sentinel Lymph Node Melanoma Metastases Scientists aimed to characterize, in sentinel lymph nodes, the subpopulations of lymphocytes that interact with metastatic melanoma cells and analyze their associations with outcome, and to determine tumor PD-L1 expression as this may provide a rational scientific basis for the administration of adjuvant anti-PD-1/PD-L1 inhibitors in sentinel lymph node positive metastatic melanoma patients. [Mod Pathol] Abstract Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells Researchers investigated the potential of discarded human thymuses, routinely removed during pediatric cardiac surgery, to be used as a novel source of therapeutic regulatory T cells. [Am J Transplant] Abstract Expression of IL-37 Contributes to the Immunosuppressive Property of Human CD4+CD25+ Regulatory T Cells Cell surface molecules and secretory cytokines were analyzed in order to determine the function of interleukin-37 (IL-37) in regulating inhibitory effect of human CD4+CD25+ regulatory T cells. [Sci Rep] Full Article Inhibition of IL-1β-mediated IRAK4 Phosphorylation by Zinc Leads to Repression of Memory Th17 Response in Humans Scientists examined antibody responses against JC polyomavirus (JCPyV) major capsid protein viral protein 1 variants in the serum and cerebrospinal fluid of healthy donors, JCPyV-positive multiple sclerosis patients treated with the anti-VLA-4 monoclonal antibody natalizumab (NAT), and patients with NAT-associated progressive multifocal leukoencephalopathy. [Immunology] Abstract Long Noncoding RNA Expression during Human B-Cell Development Researchers analyzed long noncoding RNA expression during human B-cell development by array-based expression profiling of eleven distinct flow-sorted B-cell subsets, comprising pre-B1, pre-B2, immature, naive, memory, and plasma cells from bone marrow biopsies, and naive, centroblast, centrocyte, memory, and plasmablast cells from tonsil tissue samples, respectively. [PLoS One] Full Article Elevated Concentrations of Serum Immunoglobulin Free Light Chains in Systemic Lupus Erythematosus Patients in Relation to Disease Activity, Inflammatory Status, B Cell Activity and Epstein-Barr Virus Antibodies Scientists examined the concentration of serum immunoglobulin free light chains (FLCs) in systemic lupus erythematosus (SLE) patients and investigated its association with various disease parameters in order to evaluate the role of FLCs as a potential biomarker in SLE. [PLoS One] Full Article The Imbalance between Tregs, Th17 Cells and Inflammatory Cytokines Among Renal Transplant Recipients Investigators aimed to determine the number of CD4+CD25+Foxp3+ Treg, CD4+IFN-γ–IL-17+ Th17, CD4+IFN-γ+IL-17– Th1 and CD4+IFN-γ+IL-17+ Th1/17 cells in renal transplant recipients. [BMC Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |