PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T Cell Trafficking in Colon Cancer Scientists found that polycomb repressive complex 2 (PRC2) components and demethylase JMJD3-mediated histone H3 lysine 27 trimethylation repress the expression and subsequent production of Th1-type chemokines CXCL9 and CXCL10, mediators of effector T cell trafficking. [Cancer Res] Abstract T-Cell Receptor-HLA-DRB1 Associations Suggest Specific Antigens in Pulmonary Sarcoidosis To investigate T-cell receptor-HLA-DRB1*03 interactions underlying recognition of hitherto unknown antigens, researchers performed detailed analyses of T-cell receptor expression on bronchoalveolar lavage fluid CD4+ T-cells from sarcoidosis patients. [Eur Respir J] Abstract Lamina Propria CD4+LAP+ Regulatory T Cells Are Increased in Active Ulcerative Colitis but Show Increased IL-17 Expression and Reduced Suppressor Activity The authors investigated the frequency and function of lamina propria (LP) CD4+LAP+ T cells in inflammatory bowel disease patients. LP CD3+CD8–LAP+ cells were significantly increased, when compared to controls, in active ulcerative colitis patients and not in Crohn’s disease patients. [J Crohns Colitis] Abstract MicroRNA-155-IFN-γ Feedback Loop in CD4+ T Cells of Erosive Type Oral Lichen Planus Researchers determined the role of miR-155 in immune response of oral lichen planus (OLP) and determined the expression and correlation of microRNA-155 and SOCS1 in erosive-type OLP CD4+ T cells. [Sci Rep] Full Article Anti-Inflammatory Activity of Low Molecular Weight Polysialic Acid on Human Macrophages Scientists showed that soluble low molecular weight polysialic acid with an average degree of polymerization 20 interacts with sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) and acts anti-inflammatory on human THP1 macrophages involving the SIGLEC-11 receptor. [Sci Rep] Full Article Alternative Promoter Methylation Regulates Together with Foxp3 Transcription of GARP Investigators report that transcription of human glycoprotein A repetitions predominant (GARP) in regulatory CD4 T cells is tightly regulated by two alternative promoters. [Biochim Biophys Acta] Abstract Immunomodulation of Endothelial Differentiated Mesenchymal Stromal Cells: Impact on T and NK Cells The authors sought to determine the impact of differentiation toward endothelial cells on immunoregulation by Wharton’s jelly mesenchymal stromal cells (WJ-MSCs). They co-cultured un- and differentiated MSCs with immune cells, under conditions of both direct and indirect contact. [Immunol Cell Biol] Abstract Evidence for Epigenetic Regulation of Pro-Inflammatory Cytokines, Interleukin-12 and Interferon Gamma, in Peripheral Blood Mononuclear Cells from PTSD Patients Investigators examined genome-wide histone and DNA methylation in the peripheral blood mononuclear cells (PBMCs) in post traumatic stress disorder (PTSD). PTSD patients showed increased expression of interleukin (IL)-12 in their PBMCs. [J Neuroimmune Pharmacol] Abstract Processing and MHC Class II Presentation of Exogenous Soluble Antigen Involving a Proteasome-Dependent Cytosolic Pathway in CD40-Activated B Cells Scientists investigated the MHC class II processing pathway in CD40-activated B cells (CD40Bs), as a model for activated, antigen-presenting B cells. Using CMV pp65 as a model antigen, they evaluated processing and presentation of the CD4+ T cell epitope 509-523 by human CD40Bs in Elispot assays. [Eur J Haematol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |