Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer Researchers demonstrated that glutathione and cysteine released by fibroblasts contribute to this resistance. CD8+ T cells abolish the resistance by altering glutathione and cystine metabolism in fibroblasts. [Cell] Abstract | Graphical Abstract Update on the Safety and Efficacy of Retroviral Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency Scientists investigated the medium-term outcome of gene therapy in 18 patients with adenosine deaminase-severe combined immunodeficiency for whom an HLA-identical family donor was not available. Immune reconstitution was demonstrated by normalization of T cell subsets, evidence of thymopoiesis, and sustained T cell proliferative capacity. [Blood] Abstract Extracellular Vesicles Released by CD40/IL-4 Stimulated Chronic Lymphocytic Leukemia Cells Confer Altered Functional Properties to CD4+ T Cells In order to characterize tumor extracellular vesicles (EVs) released in response to T cell-derived tumor microenvironment signals, scientists performed microRNA profiling of EVs released from chronic lymphocytic leukemia cells stimulated with CD40 and IL-4. [Blood] Abstract Naïve and Memory B Cells Exhibit Distinct Biochemical Responses Following BCR Engagement Researchers investigated the nature of BCR signaling in human splenic naïve, IgM+ memory and isotype switched memory B cells following multivalent BCR crosslinking. [Immunol Cell Biol] Abstract IL-10 Promotes Homeostatic Proliferation of Human CD8+ Memory T Cells and, When Produced by CD1c+ DCs, Shapes Naive CD8+ T-Cell Priming Investigators analyzed the role of interleukin (IL)-10 produced by human APC subsets in T-cell responses. IL-10 production was restricted to CD1c+ dendritic cells (DCs) and CD14+ monocytes. [Eur J Immunol] Abstract IL-9 Promotes the Survival and Function of Human Melanoma – Infiltrating CD4+CD8+ Double-Positive T Cells The authors documented that melanoma-infiltrating CD4+CD8+ double-positive T cells express a high level of the IL-9 receptor, which prompted them to investigate the impact of IL-9 on their biology. [Eur J Immunol] Abstract Distribution and Molecular Characterization of Human Adenovirus and Epstein-Barr Virus Infections in Tonsillar Lymphocytes Isolated from Patients Diagnosed with Tonsillar Diseases Researchers characterized the distribution of human adenovirus, Epstein-Barr virus and human cytomegalovirus in purified tonsillar T and B cell-enriched fractions isolated from three patient age groups diagnosed with tonsillar hypertrophy and chronic/recurrent tonsillitis. [PLoS One] Full Article Delayed Adaptive Immunity Is Related to Higher MMR Vaccine-Induced Antibody Titers in Children Researchers investigated whether early-life environmental factors and adaptive immune maturation prior and close to measles–mumps–rubella (MMR) immunization relate to magnitudes of vaccine-specific antibody titers. [Clin Transl Immunol] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News! |