Human Immunology News 4.24 June 21, 2016 | |
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TOP STORYIdentification of Shared TCR Sequences from T Cells in Human Breast Cancer Using Emulsion RT-PCR To determine if T-cell specificity can be harnessed to augment immunotherapies of breast cancer, researchers sought to identify the alpha-beta paired T-cell receptors (TCRs) of tumor-infiltrating lymphocytes shared between multiple patients. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators report on a Phase I study of relapsed/refractory multiple myeloma patients in which the primary objective was to identify a tolerable and potentially efficacious dose of tabalumab when combined with bortezomib. [Clin Cancer Res] Abstract | Full Article A Unique CD8+ T Lymphocyte Signature in Pediatric Type 1 Diabetes Scientists undertook separate multi-parameter analyses of single naive and activated/memory CD8+ T lymphocytes from pediatric and adult patients, with the objective of identifying cellular profiles associated with onset of type 1 diabetes. [J Autoimmun] Abstract Investigators report an immunohistochemical analysis of programmed cell death ligand 1 expression in a large series of conventional, mesenchymal, clear cell and dedifferentiated chondrosarcomas using tissue microarrays. [Mod Pathol] Abstract To evaluate the clinical potential of GSK2857916, tumor cells from seventy multiple myeloma patients were assessed for B-cell maturation antigen expression by immunohistochemistry and flow cytometry. [Br J Haematol] Abstract Researchers aimed to determine mechanisms of human regulatory T cell depletion and reconstitution after anti-CD25 monoclonal antibody treatment. [Transplantation] Abstract Scientists utilized human neural precursor cells differentiated from a human induced pluripotent cell line via an embryoid body intermediate stage (EB-NPCs). Intraspinal transplantation of EB-NPCs into mice infected with the neurotropic JHM strain of mouse hepatitis virus resulted in decreased accumulation of CD4+ T cells in the central nervous system that was concomitant with reduced demyelination at the site of injection. [PLoS One] Full Article Researchers investigated the effect of the native, citrullinated or carbamylated type II-human collagen T cell- and B cell-epitopes on the adaptive immune response in rheumatoid arthritis. [Clin Exp Immunol] Abstract Investigators found that high levels of total serum IgG, and to a lesser extent IgM, were strongly associated with freedom from coronary events [EBioMedicine] Full Article | Press Release Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSTranslational Implications for Off-the-Shelf Immune Cells Expressing Chimeric Antigen Receptors The authors review the strategies to establish “off-the-shelf” donor-derived biobanks for human application of chimeric antigen receptor+ T-cells as a drug. [Mol Ther] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field.
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INDUSTRY NEWSCellectis announced that the first patient has been treated in the Phase I study of gene edited CAR T-cells (UCART)19 in pediatric acute B-ALL at the University College of London. [Cellectis] Press Release Adaptimmune Therapeutics plc announced that the European Medicines Agency’s Committee for Orphan Medicinal Products has adopted a positive opinion recommending the company’s SPEARâ„¢ T-cell therapy targeting NY-ESO for designation as an orphan medicinal product for the treatment of soft tissue sarcoma. [Adaptimmune Therapeutics plc] Press Release Fate Therapeutics, Inc. announced the U.S. Food and Drug Administration (FDA) has cleared the company’s investigational new drug application for ProTmuneâ„¢, a programmed cellular immunotherapy consisting of donor-sourced mobilized peripheral blood cells which have been functionally modulated using two small molecules. [Fate Therapeutics, Inc.] Press Release Kite Pharma Opens State-of-the-Art T-Cell Therapy Manufacturing Facility Kite Pharma, Inc. marked the official opening of its new commercial manufacturing facility in El Segundo, California. Over 300 employees, investors and company partners attended the unveiling of the 43,500-square-foot, state-of-the-art plant. [Kite Pharma, Inc.] Press Release | |
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EVENTSNEW British HIV Association (BHIVA) Autumn Conference 2016 Visit our events page to see a complete list of events in the human immunology community.
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JOB OPPORTUNITIESNEW Tenure Track Positions – Chemical Immunology (Institute for Chemical Immunology) Research Associate – Immunology and Cell Separation (STEMCELL Technologies Inc.) Technical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Scientist – Bioengineering (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Group Leader – Immunology (Academic Medical Center) Senior Faculty Leadership Position – Immunology (Fred Hutchinson Cancer Research Center) Research Associate – Molecular and Cellular Biology of Inflammation (King’s College London) Postdoctoral Scientist – Immune Focused In Vitro Research (Celentyx Ltd) Postdoctoral Position – Tumor Immunology (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Immunology (Saarland University) Postdoctoral Fellow – Allergy and Immunology (Northwestern University-Feinberg School of Medicine) Postdoctoral Research Associate – Immunology (Benaroya Research Institute at Virginia Mason) Postdoctoral Fellowship – Immunology (Tongji Medical College) Postdoctoral Fellow – Immunology (Technische Universität München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Human Immunology News Volume 4.24 | Jun 21 2016