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Pulmonary Cell News| Human Immunology News 4.37 September 20, 2016 | |
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TOP STORYMolecular Switch Controlling Immune Suppression May Help Turn Up Immunotherapies Researchers have identified a strategy to maximize the effectiveness of anti-cancer immune therapy. They identified a molecular switch that controls immune suppression, opening the possibility to further improving and refining emerging immunotherapies that boost the body’s own abilities to fight diseases ranging from cancer to Alzheimer’s and Crohn’s disease. [Press release from UC San Diego discussing online prepublication in Nature] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Chemical Proteomic Map of Dimethyl Fumarate–Sensitive Cysteines in Primary Human T Cells Scientists found that dimethyl fumarate (DMF), but not monomethyl fumarate, blocked the activation of primary human and mouse T cells. Using a quantitative, site-specific chemical proteomic platform, they determined the DMF sensitivity of >2400 cysteine residues in human T cells. [Sci Signal] Abstract Investigators showed that overexpression of miR-24, miR-30b and miR-142-3p attenuates uptake and processing of soluble antigen ovalbumin in primary human macrophages and dendritic cells. miRNA mimic transfected antigen presenting cells exhibited defects in antigen presentation to CD4+ T-cells leading to reduced cell proliferation. [Sci Rep] Full Article Researchers investigated the suppressive effect and underlying mechanism of isoliquiritigenin, a phyto-flavonoid, on human T lymphocyte activation in vitro and in vivo. [Oncotarget] Full Article Scientists performed a comparative analysis of the capacity of purified monocytes, neutrophils, and CD4 T cells to serve as accessory cells for Vγ9Vδ2 T cell activation in response to three selective but mechanistically distinct stimuli. [J Immunol] Abstract Researchers investigated the interaction between PD-1 on invariant natural killer T (iNKT) cells and programmed death ligand on antigen-presenting cells in the context of iNKT cell stimulation. The blockade of PDL1 at the time of stimulation resulted in increased release of helper T cell 1 cytokines from iNKT cells, leading to the activation of NK cells. [Cancer Immunol Immunother] Full Article Distinctive Expression of Interleukin-23 Receptor Subunits on Human Th17 and γδ T Cells Scientists used unique interleukin-23 receptor (IL-23R) subunit-specific monoclonal antibodies, X67 and X68, and interleukin-12 receptor beta-1 subunit expression levels to evaluate the IL-23R complex on CD4 αβ TCR T helper 17 (Th17) cells and on γδ T cells. [Immunol Cell Biol] Abstract A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells Investigators showed that protein L, secreted by Finegoldia magna, a B-cell superantigen which interacts with κ+ bearing cells, induces the apoptosis of murine and human κ+ lymphoma B cells both in vitro and in vivo. [PLoS One] Full Article The authors conducted cross-sectional analyses of telomere length, a hallmark of cellular aging, of naïve and memory CD4 T cells and total CD8 T cells in the peripheral blood of 620 atomic bomb survivors as it relates to age and radiation dose, using fluorescence in situ hybridization with flow cytometry. [Radiat Res] Abstract Class I HLA Haplotypes Form Two Schools that Educate NK Cells in Different Ways Polymorphic human leukocyte antigen (HLA) class I educates natural killer (NK) cells through interactions with killer cell immunoglobulin-like receptors and by supplying peptides that bind HLA-E to form ligands for CD94/NKG2A receptors on NK cells. [Sci Immunol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWST Cells in Systemic Lupus Erythematosus Systemic lupus erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. [Curr Opin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSWaferGen Bio-systems, Inc. presented T-cell receptor (TCR) sequencing results from its ICELL8â„¢ Single-Cell System. The poster presentation, titled “A SMARTer® Approach to Profiling the Human T-cell Receptor Repertoire Using the ICELL8 Single Cell System”, demonstrates the ability to perform TCR sequencing from thousands of single cells and is a joint poster with Takara Bio USA, Inc. [WaferGen Bio-systems, Inc.] Press Release Adaptimmune Therapeutics plc announced that it has entered into a new five-year strategic manufacturing agreement with PCT for the supply of Adaptimmune’s SPEAR® T-cell therapies. [Adaptimmune Therapeutics plc] Press Release Shire plc announced that the United States Food and Drug Administration (FDA) has granted approval for CUVITRU in adult and pediatric patients two years of age and older. [Shire plc] Press Release | |
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POLICY NEWSIndustry Responds to Biosimilar User Fee Act Letter The Food and Drug Administration released the Biosimilar User Fee Act (II) performance goals letter, drawing support from trade groups representing biotechnology companies. [Drug Store News] Editorial Eleven Medicines Leap towards EU Approval Eleven new medicines have taken a giant leap closer to European Union approval after having won the backing of the Committee for Medicinal Products for Human Use. [PharmaTimes] Editorial University of Tokyo to Investigate Data Manipulation Charges against Six Prominent Research Groups The University of Tokyo announced it is launching an investigation into anonymously made claims of fabricated and falsified data appearing in 22 papers by six university research groups [Science Insider] Editorial China-Only Science Prize Honors Pathologist and Experimental Physicist Research on non-invasive pregnancy tests and superconductors earns $1 million ‘Chinese Nobels’. [Nature News] Editorial
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EVENTSNEW Herrenhäuser Conference: The Neonatal Window of Opportunity, Early Priming for Life NEW World Stem Cell Summit 2016 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Cell Separation (STEMCELL Technologies Inc.) NEW Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) NEW Postdoctoral Position – Tumor Immunology (Memorial Sloan Kettering Cancer Center) NEW Assistant Professor of Immunology (University of Texas) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Fellow – Molecular Immunology (University of California San Diego School of Medicine) Chair – Medical Biology (Masaryk University) Faculty Positions – Various Areas (Jackson Laboratory) Postdoctoral Researcher – Translational Immunology (University of Eastern Finland) Faculty Position – Immunology (Vanderbilt University Medical Center) Postdoctoral Fellow – Mucosal Immunology (University of Utah) Postdoctoral Fellow – Metastatic Breast Cancer (Purdue Center for Cancer Research) Assistant Associate – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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