Human Immunology News 6.26 July 3, 2018 | |
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TOP STORYSingle-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment Investigators profiled 45,000 immune cells from eight breast carcinomas, as well as matched normal breast tissue, blood, and lymph nodes, using single-cell RNA-seq. [Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors performed single-cell RNA sequencing of 6,311 T cells isolated from human breast cancers and showed that significant heterogeneity exists in the infiltrating T cell population. [Nat Med] Abstract Researchers identified a chimeric antigen receptor (CAR) containing the transmembrane domain of NKG2D, the 2B4 co-stimulatory domain, and the CD3ζ signaling domain to mediate strong antigen-specific natural killer (NK) cell signaling. NK cells derived from human iPSCs that expressed this CAR had a typical NK cell phenotype and demonstrated improved anti-tumor activity compared with T-CAR-expressing iPSC-derived NK cells and non-CAR-expressing cells. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract Whether human naturally-occurring dendritic cells that arise from monocytes (mo-DCs) can cross-present is unknown. Scientists used human mo-DCs and macrophages directly purified from ascites to address this question. [Nat Commun] Full Article Synthesis of Interleukin 1 Beta and Interleukin 6 in Human Lymphocytes Is Stimulated by Tributyltin Secretion of both interleukin (IL) 1β and IL-6 from human lymphocytes can be increased dependent upon the level of tributyltin (TBT) exposure. Investigators showed that the TBT-induced increases in secretion of both cytokines are due to TBT-induced increases in the synthesis of these proteins and not simply because of the release of pre-existing cytokine. [Arch Toxicol] Abstract Scientists investigated the cellular mechanisms for cannabidiol (CBD)-induced apoptosis and oxidative stress in human monocytes. Exposure of freshly isolated human monocytes to CBD induced apoptosis in a time- and concentration-dependent manner. [Free Radic Biol Med] Abstract | Graphical Abstract Researchers evaluated if local delivery of low numbers of human regulatory T cells by intradermal injection was able to prevent skin inflammation, using the humanized mouse huPBL-SCID-huSkin allograft model. [Sci Rep] Full Article The authors identified the immunomodulatory role of induced pluripotent stem cell derived-mesenchymal stem cells on resting peripheral blood mononuclear cells from allergic rhinitis patients. [Stem Cell Res Ther] Full Article Using miRNA expression profiling of Leishmania donovani–infected human macrophages, investigators showed that leishmania infection induced a genome-wide down-regulation of host miRNAs. [J Biol Chem] Abstract | Full Article Scientists aimed to find out if target organ damage in adolescents with primary hypertension was associated with thymus-dependent lymphocytes renewal reflected by changes in the T-cell subset phenotype characteristics. [J Hypertens] Abstract Using a well-characterized in vitro system, with the THP1 human macrophage cell line, the authors investigated the hypothesis that the expression of CCR5 is acutely affected by methamphetamine, and examined pathways by which this effect could happen. [PLoS One] Full Article Scientists investigated the effects of flavonoids isolated from A. heterophyllus. heartwood on chemotaxis, phagocytosis, reactive oxygen species production and myeloperoxidase activity of human phagocytes. [J Pharm Pharmacol] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSTissue-Specific Functions of Invariant Natural Killer T Cells The authors summarize the functions of invariant natural killer T cells (iNKT) cells in four tissues in which they are prevalent, namely, the liver, the lungs, adipose tissue and the intestine. Importantly, they explain how local iNKT cell responses at each site contribute to tissue homeostasis and protection from infection but can also contribute to tissue inflammation and damage. [Nat Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSMolMed S.p.A. and AbCheck s.r.o. announced that they have entered into a three-year Master Agreement aimed at providing MolMed with selected and optimized antibodies for the development of new chimeric antigen receptors (CARs), targeting both liquid and solid tumors. [Affimed N.V. (GlobeNewswire, Inc.)] Press Release TRIGR Therapeutics and ABL Bio Corporation jointly announced that it had entered into a binding agreement for TRIGR to license the global commercial rights to ABL Bio’s pipeline of novel therapeutic antibodies to treat cancer. [TRIGR Therapeutics (Business Wire, Inc.)] Press Release | |
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POLICY NEWSLGBTQ Scientists Are Still Left Out People who identify as LGBTQ are leaking out of the scientific pipeline in similar ways to women and those from minority ethnic groups. But many initiatives to increase diversity do not support them. Including LGBTQ people in diversity initiatives would foster their representation, and it could bring in perspectives that improve science itself. [Nature News] Editorial Europe’s Biggest Research Fund Cracks Down on ‘Ethics Dumping’ Ethics dumping — doing research deemed unethical in a scientist’s home country in a foreign setting with laxer ethical rules — will be rooted out in research funded by the European Union, officials announced. [Nature News] Editorial U.S. Lawmakers Want NIH and CDC Foundations to Say More about Donors A key congressional spending panel has fired a shot across the bow of two federally chartered medical foundations, warning that the way they disclose information about donors may not pass muster. [ScienceInsider] Editorial
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EVENTSNEW Aegean Conferences: 1st International Conference on Oral Mucosal Immunity and Microbiome Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Professorship – Molecular Immune Regulation (Kiel University) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Postdoctoral Fellow – Immunoengineering for Muscle Regeneration (Duke University) PhD Student Positions – Immunology (Multiple Locations) Postdoctoral Fellow – Immunology (Boston University School of Medicine) Postdoctoral Fellow – Innate Immune Signaling (Houston Methodist Research Institute) Scientist/Senior Scientist – Lentivirus Production (Obsidian Therapeutics) Scientist/Senior Scientist – Bioinformatics and Data Sciences (Obsidian Therapeutics) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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