LABORATORY RESEARCH Functional SNP in the MicroRNA-367 Binding Site in the 3′UTR of the Calcium Channel Ryanodine Receptor Gene 3 (RYR3) Affects Breast Cancer Risk and Calcification Scientists confirmed that microRNA-367 regulates the expression of a reporter gene driven by the RYR3 3′UTR and that the regulation was affected by the RYR3 genotype. [Proc Natl Acad Sci U S A] Mechanistic Insight into Myc Stabilization in Breast Cancer Involving Aberrant Axin1 Expression Researchers report that Myc protein stability is increased in a number of breast cancer cell lines and this correlates with increased phosphorylation at serine 62 and decreased phosphorylation at threonine 58. [Proc Natl Acad Sci U S A] Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer Since genetic anticipation has been observed in familial breast cancer, researchers aimed to study telomere length in familial breast cancer patients and hypothesized that genetic defects causing this disease would affect telomere maintenance resulting in shortened telomeres. [PLoS Genet] Understanding the Metabolic Basis of Drug Resistance: Therapeutic Induction of the Warburg Effect Kills Cancer Cells Scientists investigated whether epithelial-stromal metabolic coupling interactions might be the basis of tamoxifen-resistance in ER(+) breast cancer cells. [Cell Cycle] Lapatinib, a Preventive/Therapeutic Agent Against Mammary Cancer, Suppresses Receptor Tyrosine Kinase-Mediated Signaling through Multiple Signaling Pathways In this study, female Sprague-Dawley rats were given methylnitrosourea by intravenous injection resulting in the development of multiple estrogen receptor–positive tumors. [Cancer Prev Res] Mammary Gland Density Predicts the Cancer Inhibitory Activity of the N-3 to N-6 Ratio of Dietary Fat This study investigated the effect of a broad range of dietary ratios of n-3:n-6 fatty acids on mammary gland density and mammary cancer risk. [Cancer Prev Res] Nuclear Localization of Maspin Is Essential for its Inhibition of Tumor Growth and Metastasis Investigators hypothesized that the tumor suppressor activity of maspin may require nuclear localization, and that the discordance between clinical and experimental reports is a consequence of the variable subcellular distribution of maspin. [Lab Invest] Functional Viability Profiles of Breast Cancer Researchers have carried out a functional genetic screen in >30 commonly used models of breast cancer to identify genes critical to the growth of specific breast cancer subtypes. [Cancer Discov] CLINICAL RESEARCH Relevance of Breast Cancer Hormone Receptors and Other Factors to the Efficacy of Adjuvant Tamoxifen: Patient-Level Meta-Analysis of Randomized Trials Scientists undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21 457) in early breast cancer of about 5 years of tamoxifen versus no adjuvant tamoxifen, with about 80% compliance. [Lancet] Phase II Trial of Dasatinib in Patients with Metastatic Breast Cancer Using Real-Time Pharmacodynamic Tissue Biomarkers of Src Inhibition to Escalate Dosing A Phase II study of dasatinib was conducted to evaluate 16-week progression-free rate and tolerability in patients with previously treated metastatic breast cancer. [Clin Cancer Res] Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor Positive and Negative Breast Cancer: A Nested Case-Control Study In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone and sex hormone binding globulin levels were measured in pre-diagnostic serum samples from postmenopausal women not using HRT at blood donation. [Cancer Prev Res] |