LABORATORY RESEARCH Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves a Her-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model Scientists examined whether therapeutically targeted delivery of a synthetic STAT-3 inhibitor to the tumor microenvironment, combined with a HER-2 DNA vaccine can improve immune surveillance against HER-2+ breast cancer and prevent its recurrence. [Cancer Res] Steroid Hormone Modulation of RET through Two Estrogen Responsive Enhancers in Breast Cancer Researchers identified key sequences that are required for RET −49.8 and RET +32.8 estrogen responsiveness, including motifs known to be bound by ESR1, FOXA1 and TFAP2C. [Hum Mol Genet] A Refined Molecular Taxonomy of Breast Cancer Investigators analyzed the transcriptomes of 537 breast tumors using three unsupervised classification methods. [Oncogene] MUC16 Induced Rapid G2/M Transition Via Interactions with JAK2 for Increased Proliferation and Anti-Apoptosis in Breast Cancer Cells In the present study, scientists investigated the role of MUC16 in breast cancer and its underlying mechanisms. [Oncogene] HER2-Affitoxin: A Potent Therapeutic Agent for the Treatment of HER2-Overexpressing Tumors To provide an alternative HER2-targeted therapy, researchers have developed and characterized a novel recombinant protein combining an HER2-specific Affibody and modified Pseudomonas aeruginosa exotoxin A (PE 38). [Clin Cancer Res] Exploring Breast Cancer Estrogen Disposition: The Basis for Endocrine Manipulation Based on recent results from exploring tissue estrogens together with estrogen-synthesizing and estrogen-regulated gene expression levels, investigators proposed a new model to explain elevated breast tissue estrogen levels. [Clin Cancer Res] Lapatinib, a Preventive/Therapeutic Agent Against Mammary Cancer, Suppresses Receptor Tyrosine Kinase-Mediated Signaling through Multiple Signaling Pathways In this study, female Sprague-Dawley rats were given methylnitrosourea by intravenous injection resulting in the development of multiple estrogen receptor–positive tumors. [Cancer Prev Res] Radiation-Enhancement of MDA-MB-231 Breast Cancer Cell Invasion Prevented by a Cyclooxygenase-2 Inhibitor The role of cyclooxygenase-2, an inflammatory enzyme frequently induced by radiotherapy, was investigated. [Br J Cancer] CLINICAL RESEARCH Association of Occult Metastases in Sentinel Lymph Nodes and Bone Marrow with Survival Among Women with Early-Stage Invasive Breast Cancer The objective of this study is to determine the association between survival and metastases detected by immunochemical staining of sentinel lymph nodes and bone marrow specimens from patients with early-stage breast cancer. [JAMA] Pathologic Complete Response After Neoadjuvant Chemotherapy Plus Trastuzumab Predicts Favorable Survival in Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: Results from the TECHNO Trial of the AGO and GBG Study Groups The purpose of this study is to evaluate the efficacy and safety of epirubicin and cyclophosphamide followed by paclitaxel and trastuzumab as neoadjuvant treatment in patients with human epidermal growth factor receptor 2–overexpressing breast cancer. [J Clin Oncol] Obesity and Survival Among Black Women and White Women 35 to 64 Years of Age at Diagnosis with Invasive Breast Cancer The purpose of this study is to evaluate the effect of obesity on survival among black women and white women with invasive breast cancer and to determine whether obesity explains the poorer survival of black women relative to white women. [J Clin Oncol] Mammographic Breast Density and Subsequent Risk of Breast Cancer in Postmenopausal Women According to Tumor Characteristics Researchers aimed to determine whether the associations between breast density and subsequent breast cancer varied by tumor characteristics. [J Natl Cancer Inst] Circulating Sex Hormones and Breast Cancer Risk Factors in Postmenopausal Women: Reanalysis of 13 Studies Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. [Br J Cancer] |