LABORATORY RESEARCH CCL2 Recruits Inflammatory Monocytes to Facilitate Breast-Tumor Metastasis Scientists defined the origin of the metastasis-associated macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumors in mice. [Nature] A Function for Cyclin D1 in DNA Repair Uncovered by Protein Interactome Analyses in Human Cancers To elucidate the molecular functions of cyclin D1 in human cancers, researchers performed a proteomic screen for cyclin D1 protein partners in several types of human tumors. [Nature] Acidic Nuclear Phosphoprotein 32kDa (ANP32)B-Deficient Mouse Reveals a Hierarchy of ANP32 Importance in Mammalian Development Investigators reported that ANP32B expression is associated with a poor prognosis in human breast cancer, consistent with the increased levels of Anp32b mRNA present in proliferating wild-type (WT) murine embryonic fibroblasts and stimulated WT B and T lymphocytes. [Proc Natl Acad Sci U S A] High Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Promote Vγ9Vδ2 T-Cell Chemotaxis and Cytotoxicity In Vivo In this study scientists investigated the correlation between the anticancer activities of Vγ9Vδ2 T cells and the intracellular IPP/ApppI levels in zoledronic acid-treated breast cancer cells in vitro and in vivo. [Cancer Res] Tumor Microenvironment-Derived Proteins Dominate the Plasma Proteome Response During Breast Cancer Induction and Progression Researchers employed a systems biology approach to characterize the plasma proteome response in the inducible HER2/neu mouse model of breast cancer during tumor induction, progression and regression. [Cancer Res] Autophagy Protects Breast Cancer Cells from Epirubicin-Induced Apoptosis and Facilitates Epirubicin-Resistance Development The study showed that epirubicin induced autophagy in human breast cancer MCF-7 cells. [Autophagy] Enhanced Metastasis Suppression by Targeting TRAIL Receptor 2 in a Murine Model of Triple-Negative Breast Cancer Several metastatic, triple (estrogen receptor, progesterone receptor and HER2)-negative cancer cell lines were treated with human agonistic monoclonal antibodies targeting TRAIL-R1 (mapatumumab) or TRAIL-R2 (lexatumumab). The effects on cell viability, apoptosis, and caspase-8 activation were determined. [Clin Cancer Res] The Peptide-Hormone Glucagon-Like Peptide-1 Activates cAMP and Inhibits Growth of Breast Cancer Cells As obesity and type 2 diabetes mellitus are associated with increased risk of breast cancer, investigators aimed to explore the effects of glucagon-like peptide-1 and exendin-4, on breast cancer cells. [Breast Cancer Res Treat] CLINICAL RESEARCH Exemestane for Breast-Cancer Prevention in Postmenopausal Women Exemestane significantly reduced invasive breast cancers in postmenopausal women who were at moderately increased risk for breast cancer. [New Engl J Med] High Independent Prognostic and Predictive Value of Circulating Tumor Cells Compared with Serum Tumor Markers in a Large Prospective Trial in First-Line Chemotherapy for Metastatic Breast Cancer Patients Circulating tumor cells were counted with CellSearch® at baseline, before cycle 2 and cycle 3 or 4 in 267 metastatic breast cancer patients on first-line chemotherapy with/without targeted therapy. [Ann Oncol] Risk of Primary Non-Breast Cancer after Female Breast Cancer by Age at Diagnosis Scientists identified 304,703 women diagnosed with breast cancer during 1943-2006 in the Cancer Registries of Denmark, Norway and Finland. Standardized incidence ratios or relative risks of subsequent non-breast cancer by age at cancer diagnosis were calculated using Poisson regression models adjusted for country, calendar period, length of follow-up and treatment. [Cancer Epidemiol Biomarkers Prev] |