Mammary Cell News Volume 2.37 | Sep 30 2010

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    Mammary Cell News 2.37 September 30, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Bone-Diease Drug Could Treat Breast Cancer  ShareThis
    Two studies published in Nature show how one ingredient of hormone-replacement therapy, a synthetic version of the hormone progesterone called a progestin, can cause breast cancer in mice by activating the protein RANKL. [Press release from Nature News discussing online prepublication in Nature]

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    SPECIAL FEATURE

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    SCIENCE NEWS

    Yale Researchers Find Protein is a Key Tool in Chromosomal Repair Kit
    Scientists have discovered how one protein plays a key role in repairing damage to chromosomes that can cause different types of cancer. [Press release from Yale University discussing online prepublication in Nature Structural & Molecular Biology]

    Triple-Negative Breast Cancers May Have Unique Therapeutic Target
    Patients with triple-negative breast cancer, one of the hardest subtypes to treat, may have a unique biomarker that would enable them to receive more targeted therapy. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development]

    Circulating Tumor Cells Can Provide ‘Real-time’ Information on Patient’s Current Disease State
    Circulating tumor cells may be a promising alternative, noninvasive source of tumor materials for biomarker assessment. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development]

    Novel Biomarker May Predict Response to New VEGF Receptor Inhibitor
    Researchers believe there may be a way to predict, based on individual tumors, those patients who are more likely to respond to the investigational new drug tivozanib. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development]

    Increased Risk of Other Cancers for Relatives of Women with Early Onset Breast Cancer
    Close relatives of women diagnosed with breast cancer before the age of 35 years are at an increased risk of developing other cancers, according to a study. [Press release from the University of Melbourne discussing online prepublication in the British Journal of Cancer]

    Mayo Collaboration Finds Source of Breast Drug Side Effect
    Mayo Clinic researchers and their international colleagues have discovered genetic variants that lead to severe arthritis for a subset of women when taking aromatase inhibitors to treat their breast cancer. [Press release from the University of Melbourne discussing online prepublication in the Journal of Clinical Oncology]

    Cancer-Associated Long Non-Coding RNA Regulates Pre-mRNA Splicing
    Researchers report that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing. [Press release from the University of Illinois discussing online prepublication in Molecular Cell]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    RANK Ligand Mediates Progestin-Induced Mammary Epithelial Proliferation and Carcinogenesis
    The current study highlights a potential role for RANKL inhibition in the management of proliferative breast disease. [Nature]

    Osteoclast Differentiation Factor RANKL Controls Development of Progestin-Driven Mammary Cancer
    Here, researchers show that the in vivo administration of medroxyprogesterone acetate triggers massive induction of the key osteoclast differentiation factor RANKL (receptor activator of NF-kappaB ligand) in mammary-gland epithelial cells. [Nature]

    Cooperation of Breast Cancer Proteins PALB2 and Piccolo BRCA2 in Stimulating Homologous Recombination
    Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. The studies provide the first biochemical insights into PALB2’s function with piccolo BRCA2 as a mediator of homologous recombination in DNA double-strand break repair. [Nat Struct Mol Biol]

    Phosphorylation of eEF1A1 at Ser300 by TBetaR-I Results in Inhibition of mRNA Translation
    Phosphorylation of eEF1A1 by type I TGF-beta receptor is a novel regulatory mechanism that provides a direct link to regulation of protein synthesis by TGF-beta, as an important component in the TGF-beta-dependent regulation of protein synthesis and cell proliferation. [Curr Biol]

    Cooperation of Tissue Factor Cytoplasmic Domain and PAR2 Signaling in Breast Cancer Development
    Here, researchers show that cancer cell PAR2 signaling promotes angiogenesis independent of PAR2 phosphorylation at the recognized beta-arrestin recruitment site. [Blood]

    LIM Kinases are Required for Invasive Path Generation by Tumor and Tumor-Associated Stromal Cells
    Using siRNA-mediated knockdown or a novel small molecule inhibitor, researchers show LIMK was required for path generation by leading tumor cells and nontumor stromal cells during collective tumor cell invasion. [J Cell Biol]

    WNT11 Expression is Induced by ERRAlpha and Beta-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration
    The data provide evidence for an autocrine regulatory loop involving transcriptional upregulation of WNT11 by ERRalpha and beta-catenin that influences the migratory capacity of cancer cells. [Cancer Res]

    CLINICAL RESEARCH

    Value of Early Referral to Fertility Preservation in Young Women With Breast Cancer
    The purpose of this study was to determine whether early referral to reproductive specialists improves fertility preservation outcomes and reduces delay in adjuvant treatment in young women with breast cancer. [J Clin Oncol]

    Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors
    Researchers performed a case-control genome-wide association study to identify single nucleotide polymorphisms associated with musculoskeletal adverse events in women treated with aromatase inhibitors for early breast cancer. [J Clin Oncol]


    INDUSTRY NEWS

    Quantum Immunologics Announces Clinical Study Collaboration with Florida Cancer Institute-New Hope
    Quantum Immunologics, Inc., is pleased to announce that it has completed a Clinical Study Agreement with Florida Cancer Institute-New Hope. [Florida Cancer Institute-New Hope Press Release]

    Cellceutix Nearing Completion of Toxicity Studies for Its Cancer Compound for the Treatment of Resistant Lung and Breast Cancers
    Cellceutix Corporation announced that it has completed its first species toxicity study under the conditions prescribed by United States Food and Drug Administration (FDA) Good Laboratory Practices regulations. [MarketWire]


    POLICY NEWS

    NIH Grants Will Advance Studies of the Form and Function of Proteins
    The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. [National Institutes of Health, United States]

    NCBI Launches the Database of Genomic Structural Variations
    The National Institutes of Health announced the launch of a new resource, called the Database of Genomic Structural Variation, or dbVar, to help scientists understand how differences in DNA contribute to human health and disease. [National Institutes of Health, United States]

    NIH Releases Biennial Report of the Director
    Dr. Francis S. Collins, M.D., Ph.D, director of the National Institutes of Health, announced the release of the Biennial Report of the Director, NIH, for fiscal years 2008 and 2009. The report provides an integrated portrait of NIH research activities, making it easy for Congress, advocates and patient groups and the general public to understand the many activities of the agency. [National Institutes of Health, United States]

    The NCI Cancer Immunotherapy Trials Network (CITN) Seeks Member Clinical Sites (NOT-CA-10-034) [National Institutes of Health, United States]

    Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (PAR-10-286) [National Institutes of Health, United States]

    Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States]

    National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-23852) [National Institutes of Health, United States]

    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-23847) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-23849) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23860) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23952) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
    October 1, 2010
    National Harbor, United States

    2010 Breast Cancer Symposium
    October 1-3, 2010
    Washington, DC, United States

    2010 World Stem Cell Summit
    October 4-6, 2010
    Detroit, United States

    2nd International Inflammatory Breast Cancer Conference
    October 6-7, 2010
    Marseille, France

    35th European Society for Medical Oncology (ESMO) Congress
    October 8-12, 2010
    Milan, Italy

    Institute for Genomic Medicine Inaugural Symposium
    October 11-12, 2010
    San Diego, United States

    New York Stem Cell Foundation 5th Annual Translational Stem Cell Research Conference
    October 12-13, 2010
    New York City, United States

    International Symposium on Breast Cancer Prevention: Nutrition, Communications and Public Policy
    October 18-19, 2010
    West Lafayette, United States

    6th Modern Drug Discovery & Development Summit (M3D)
    October 20-22, 2010
    San Francisco, United States

    16th World Congress of the Senologic International Society
    October 20-22, 2010
    Valencia, Spain

    American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference
    October 21-22, 2010
    Washington, DC, United States

    MENA Oncology Conference
    October 22-23, 2010
    Cairo, Egypt

    Frontiers in Tumour Progression
    October 24-27, 2010
    Madrid, Spain

    2nd Annual Stem Cells Asia and Regenerative Medicine Congress
    October 26-28, 2010
    Seoul, Korea

    UAE Cancer Congress 2010
    October 28-30, 2010
    Dubai, United Arab Emirates

    6th National Cancer Research Institute (NCRI) Conference
    November 7-10, 2010
    Liverpool, United Kingdom

    9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
    November 7-10, 2010
    Philadelphia, United States

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
    November 16-19, 2010
    Berlin, Germany

    33rd Annual San Antonio Breast Cancer Symposium
    December 8-12, 2010
    San Antonio, United States

    Epithelial Plasticity and Epithelial to Mesenchymal Transition
    January 21-26, 2011
    Vancouver, Canada

    Select Biosciences 5th Annual Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    28th Annual Miami Breast Cancer Conference
    March 9-12, 2011
    Miami, United States

    American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
    April 2-6, 2011
    Orlando, United States

    International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
    June 15-18, 2011
    Toronto, Canada

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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