LABORATORY RESEARCH
Annexin-1 Interacts with NEMO and RIP1 to Constitutively Activate I?B Kinase Complex and Nuclear Factor-?B: Implication in Breast Cancer Metastasis The molecular mechanisms underlying constitutive nuclear factor-?B activation in solid tumors has not been elucidated. Scientists show that Annexin-1 (ANXA1) is involved in this process, and suppression of ANXA1 in highly metastatic breast cancer cells impedes migration and metastasis capabilities in vitro and in vivo. [Oncogene]
Identification of PUMA as an Estrogen Target Gene That Mediates the Apoptotic Response to Tamoxifen in Human Breast Cancer Cells and Predicts Patient Outcome and Tamoxifen Responsiveness in Breast Cancer Here, researchers have identified the BCL-2 homology 3-only, pro-apoptotic regulator, PUMA (p53 upregulated modulator of apoptosis) as an estrogen target gene that is acutely downregulated in response to estrogen in breast cancer cell lines, independently of their p53 status. [Oncogene]
Alternative TFAP2A Isoforms Have Distinct Activities in Breast Cancer Findings suggest that TFAP2A isoforms may be differentially regulated during breast tumorigenesis and this, coupled with differences in their transcriptional activity, may impact on tumor responses to tamoxifen therapy. [Breast Cancer Res]
Anti-Tumor Activity of the Hsp90 Inhibitor IPI-504 in HER2 Positive Trastuzumab-Resistant Breast Cancer The aim of this study was to assess the anti-tumor activity of the heat shock protein 90 (Hsp90) inhibitor IPI-504 in trastuzumab-resistant, HER2 overexpressing breast cancer cells. [Mol Cancer Ther]
Primary Tumor Dependent Inhibition of Tumor Growth, Angio-Genesis, and Perfusion of Secondary Breast Cancer in Bone Since breast cancer has a high propensity to spread to bone, scientists used an in vivo xenograft model to determine the impact of growing breast cancer cells (MCF-7) in the mammary fat pad on the microvascular properties of subsequently inoculated secondary breast cancer tumors in bone. [J Orthop Res]
Pre- and Postpubertal Irradiation Induces Mammary Cancers with Distinct Expression of Hormone Receptors, Erbb Ligands, and Developmental Genes in Rats Here researchers examined how the mechanism of cancer development relates to the age at exposure to ionizing radiation or the carcinogen 1-methyl-1-nitrosourea. [Mol Carcinog]
DNA Methylation Changes in Murine Breast Adenocarcinomas Allow the Identification of Candidate Genes for Human Breast Carcinogenesis Investigators present a model in which comparative epigenetic techniques can be used to identify novel candidate genes important for human breast tumorigenesis, in both primary and metastatic tumors. [Mamm Genome]
CLINICAL RESEARCH Eribulin Monotherapy Versus Treatment of Physician’s Choice in Patients with Metastatic Breast Cancer (EMBRACE): A Phase III Open-Label Randomized Study Scientists aimed to compare overall survival of heavily pretreated patients receiving eribulin versus currently available treatments. [Lancet]
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer This Phase III study compared the efficacy and safety of bevacizumab when combined with several standard chemotherapy regimens versus those regimens alone for first-line treatment of patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. [J Clin Oncol]
Serum HER2 Testing in Patients with HER2-Positive Breast Cancer: The Death Knell Tolls Researchers assessed whether identification of circulating concentrations of human epidermal growth factor receptor 2 (HER2) extracellular domain have clinical usefulness for management of patients with HER2-positive breast cancer. [Lancet Oncology]
Methylated Genes in Breast Cancer: Associations with Clinical and Histopathological Features in a Familial Breast Cancer Cohort Investigators compared associations of DNA methylation with tumor stage, hormone/growth receptor status, and clinical outcomes in a familial breast cancer cohort. [Cancer Biol Ther]
Identifying Factors Associated with Falls in Postmenopausal Breast Cancer Survivors: A Multi-Disciplinary Approach The objective of the study is to identify neuromuscular, balance, and vision factors that contribute to falls in recently treated breast cancer survivors and explore links between fall risk factors and cancer treatment. [Arch Phys Med Rehabil] |