Mammary Cell News 8.23 June 16, 2016 | |
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TOP STORYDuring a monthly cycle in humans, stem cells within the breast undergo a phase called proliferation, where cells rapidly multiply in response to the hormone progesterone. Researchers have discovered that if these cells lack BRCA1, they accumulate DNA damage as they multiply, which triggers NF-κB, a protein complex normally involved in the proliferation of immune cells. [Press release from the University of Ottawa discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHResponses to hypoxia can be mediated epigenetically, thus scientists investigated whether bromodomain and extra-terminal inhibitor (BETi) JQ1 could impair the triple negative breast cancer response induced by hypoxia and exert anti-tumor effects. [Oncogene] Full Article | Press Release Researchers identified the serine/threonine-specific kinase p38 as a druggable upstream regulator of FOXC2 stability and function that elicits phosphorylation of FOXC2 at serine 367. [Oncogene] Full Article The authors showed that simultaneous overexpression of the mitotic checkpoint protein Mad2 with KrasG12D or Her2 in mammary glands of adult mice results in mitotic checkpoint overactivation and a delay in tumor onset. [Cell Rep] Full Article | Graphical Abstract Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics Scientists showed how multikinase inhibitor antiangiogenics induce hypoxia correction in spontaneous breast and lung tumor models. When this happens, the tumors downregulate glycolysis and switch to long-term reliance on mitochondrial respiration. [Cell Rep] Full Article | Graphical Abstract | Press Release COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis Researchers revealed that cyclo-oxygenase (COX)-2 induces cancer stem-like cells (SLC) by EP4-mediated NOTCH/WNT signaling. Ectopic COX-2 over-expression in MCF-7 and SKBR-3 cell lines resulted in: increased migration/invasion/proliferation, EMT, elevated SLCs, increased ALDH activity and co-localization of COX-2 and SLC markers in spheroids. [Stem Cells] Abstract TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex Phosphoproteomics of a xenograft-derived in vitro model comprising four isogenic cell lines with increasing metastatic potential implicated transient receptor potential vanilloid subtype 4 (TRPV4) in breast cancer metastasis. [Sci Rep] Full Article Investigators determined the ability of suberoylanilide hydroxamic acid (SAHA) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as single agents or in combination to inhibit the growth and survival of MCF-7 and MDA-MB-231 breast cancer cells. Their results demonstrate that the distinct effects of SAHA or TRAIL individually and in combination on the proliferation, cell viability, apoptosis, cell cycle distribution, and morphological changes of MDA-MB-231 and MCF-7 cells. [Sci Rep] Full Article Epigenetic Regulation of Soluble Guanylate Cyclase (sGC) β1 in Breast Cancer Cells There is no information on sGC regulation by epigenetic mechanisms. Scientists examined the role of histone deacetylase inhibitors in regulating sGCα1 and -β1 expression in human breast cancer MDA-MB-231 and MDA-MB-468 cell lines. [FASEB J] Abstract | Press Release CLINICAL RESEARCHResearchers evaluated the association of the intrinsic subtypes of breast cancer with outcome and/or benefit in hormone receptor-positive metastatic breast cancer. [JAMA Oncol] Full Article | Press Release | |
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REVIEWSROS Homeostasis and Metabolism: A Dangerous Liaison in Cancer Cells The reviewers describe how mitochondria have a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells. They discuss the potential therapeutic use of agents that directly or indirectly block metabolism. [Eur J Cancer] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field.
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SCIENCE NEWSScientists have produced a revolutionary new design for the imaging component of a Molecular Breast Imaging system that can replace the collimator on a commercially available breast imager and enable Molecular Breast Tomosynthesis. [Press release from Dilon Technologies, Inc. (PR Newswire Association LLC.) discussing research presented at the 2016 Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting, San Diego] Press Release | |
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INDUSTRY NEWSCantargia Receives Notice of Allowance from USPTO on IL1RAP in Solid Tumors The United States Patent and Trademark Office (“USPTO”) has issued a Notice of Allowance for Cantargia’s patent application on IL1RAP as target molecule for antibody therapy of several types of solid tumors. [Cantargia AB] Press Release Proton Therapy Arrives at Miami Cancer Institute Miami Cancer Institute at Baptist Health South Florida has welcomed the future of cancer care with the arrival of its 220-ton proton therapy cyclotron. Proton therapy destroys cancer cells with highly-targeted doses of radiation while avoiding healthy tissue and minimizing side effects, making it particularly effective in treating childhood cancers and adult cancers of the brain, liver and lung, as well as certain left-sided breast cancers and prostate cancers. [Miami Cancer Institute (Business Wire)] Press Release
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EVENTSNEW International Conference on Stem Cell Engineering 2016 Visit our events page to see a complete list of events in the mammary cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Molecular Genetics of Breast Cancer (German Cancer Research Centre) Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.) Publisher – Genome & BMC Biology, Genome & BCM Medicine (Springer Nature) Postdoctoral Fellowship – Cancer Research (German Cancer Research Center) Postdoctoral Fellow – Proteogenomic Bioinformatics of Breast Cancer (Lund University) Postdoctoral Fellow – Mammary Gland Biology and Breast Cancer (University of Amsterdam) Clinical Scientist – Phase III Trial in HER2+ (University of Padova) Postdoctoral Fellow – Cancer Biology (Hamad bin Khalifa University) PhD Fellow – Small X-Ray Angle for Breast Cancer Diagnosis (CEA Tech) Postdoctoral Fellow(s) – Various Projects (National University of Singapore) Research Associate – Various Medical Disciplines (Jinan University) Postdoctoral Fellow – RNA Splicing in Breast Cancer (Memorial Sloan Kettering Cancer Center) Scientist – Cancer Research (Institute of Clinical Physiology) Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center) Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mammary Cell News Volume 8.23 | Jun 16 2016