Mammary Cell News 9.05 February 9, 2017 | |
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TOP STORYScientists demonstrated how a new small-molecule activator of unc-51 like autophagy activating kinase 1 (ULK1), the mammalian homolog of yeast Atg1, can regulate cell death. [Autophagy] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHThe authors found that RNF20 and RNF40 expression and global H2Bub1 are relatively low, and USP44 expression is relatively high, in basal-like breast tumors compared with luminal tumors. Consistent with a tumor-suppressive role, silencing of RNF20 in basal-like breast cancer cells increased their proliferation and migration, and their tumorigenicity and metastatic capacity, partly through upregulation of inflammatory cytokines. [Cell Death Differ] Abstract CGI-99 Promotes Breast Cancer Metastasis via Autocrine Interleukin-6 Signaling Researchers reported that CGI-99 was overexpressed in breast cancer tissues from patients with metastatic recurrence within 5 years. They found that CGI-99 increases breast cancer stem cell properties, and potentiates efficient tumor lung colonization and outgrowth in vivo. [Oncogene] Abstract SILAC expression profiling and phosphopeptide enrichment of a relevant, non-transformed, immortalized human mammary luminal epithelial cell model were used to profile ErbB2-dependent differences in protein expression and phosphorylation events triggered via EGFR and ErbB3 in the context of ErbB2 overexpression. [Mol Cell Proteomics] Abstract | Full Article Investigators found that sorted SUM159PT cell populations with high ADAM12 levels had elevated expression of cancer stem cell markers and an increased ability to form mammospheres. ADAM12 knockdown reduced cell migration and invasion, decreased anoikis resistance, and compromised mammosphere formation. [Mol Cancer] Full Article Scientists observed decreased expression of Star-PAP in breast cancer cell lines and tissues. Ectopic Star-PAP expression inhibited proliferation as well as colony-forming ability of breast cancer cells. [Cell Death Dis] Full Article Loss of DLG5 Promotes Breast Cancer Malignancy by Inhibiting the Hippo Signaling Pathway The exact relationship between discs large homolog 5 (DLG5) and yes-associated protein (YAP) is not clear. Investigators showed that loss of DLG5 promoted breast cancer cell proliferation by inhibiting the Hippo signaling pathway and increasing nuclear YAP expression. [Sci Rep] Full Article The authors observed that signal transducer and activator of transcription 3 (STAT3) exerted anti-apoptotic effects in breast cancer cells. MiR-17-5p induced apoptosis in breast cancer cells, and overexpression of miR-17-5p sensitized MCF-7 cells to paclitaxel-induced apoptosis via STAT3. These results demonstrate a novel pathway via which miR-17-5p inhibits STAT3 and increases p53 expression to promote apoptosis in breast cancer cells. [Oncotarget] Full Article Scientists measured sera exosome proteome in breast cancer (BCa)-bronchiectasis nontuberculous mycobacterium (NTMnb) subjects and controls by mass spectroscopy. Extracellular matrix protein 1 (ECM1) was detected exclusively in the circulating exosomes of 82% of the BCa-NTMnb cases. Co-culture of ECM1+ exosomes with normal human mammary epithelial cells induced epithelial to mesenchymal transition accompanied by increased Vimentin/CDH1 expression ratio and glutamate production. [Oncotarget] Full Article The authors present a novel mechanobiology-based invasiveness assay to rapidly and quantitatively evaluate the mechanical invasiveness of metastatic cancer cells and identify invasive subpopulations, without need for chemoattractants and independent of serum content. [Tissue Eng Part C Methods] Abstract CLINICAL RESEARCHPatients with HER2-negative metastatic breast cancer were randomized to receive either concurrent capecitabine plus docetaxel or sequential single-agent docetaxel followed by single-agent capecitabine at progression. A baseline circulating tumor cell (CTC) count ≥2 CTCs/7.5 mL was associated with worse prognosis. [Breast Cancer Res Treat] Abstract | |
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REVIEWSLong Non-Coding RNAs in Triple Negative Breast Cancer The authors summarized the existed knowledge on the systematics, biology, and function of long non-coding RNAs (lncRNAs). The advances from the most recent studies of lncRNAs in the predicament of breast cancer, triple negative breast cancer, are highlighted, especially the functions of specifically selected lncRNAs. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSTapImmune, Inc. announced it has successfully completed a multi-gram scale-up and GMP manufacturing of a second clinical lot of TPIV 200, the company’s multi-epitope T-cell vaccine targeting folate receptor alpha. The manufactured vaccine product will be used to supply an ongoing Phase II study of TPIV 200 for the treatment of platinum-sensitive ovarian cancer, as well as a planned Phase II study sponsored by the Mayo Clinic for treating triple-negative breast cancer. [TapImmune, Inc.] Press Release Canadian Cancer Society and Canadian Breast Cancer Foundation Finalize Merger The Canadian Cancer Society and the Canadian Breast Cancer Foundation confirmed that the merger of the two charities completed. The new organization will be stronger and better able to increase impact on cancer research and support programs across all cancers while also increasing operational efficiencies. [The Canadian Cancer Society] Press Release | |
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POLICY NEWSFrench Auditors Criticize €5-Billion Science Super-Campus Near Paris France’s government auditor has taken a sharp swipe at efforts to develop a science super-campus near Paris that, by 2020, was supposed to rival the world’s top campus universities, such as the US Massachusetts Institute of Technology. [Nature News] Editorial U.S. Senate Bill Aims to Make Sure Federal Scientists Aren’t ‘Muzzled’ Congressional Democrats are rallying behind a bill to protect federal scientists from attempts to interfere with scientific discourse and dissemination of research results. [ScienceInsider] Editorial The Marches for Science, on One Global Interactive Map Weinberg, Berman, and an anthropology doctoral student Valorie Aquino, officially announced that a March for Science would be held on 22 April in Washington, D.C. Science advocates in more than 100 cities around the world say they will hold allied demonstrations the same day. [ScienceInsider] Editorial
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EVENTSNEW Reversion of Primed hPSCs to Naive-Like State Training Course Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant or Associate Professor – Breast Cancer (Roswell Park Cancer Institute) Postdoctoral Positions – Molecular Cancer Research (University of Copenhagen) Postdoctoral Fellow – Breast Cancer Research (Gundersen Health System) Postdoctoral Researcher – Breast Cancer Epidemiology (Karolinska Institutet) Postdoctoral Associate – Department of Therapeutic Radiology (Yale University School of Medicine) Postdoc Positions – Molecular Cancer Biology and Bioinformatics (University of Pittsburgh) Postdoctoral Fellow – Breast Cancer (University of Hawaii Cancer Center) Postdoctoral Fellow – Cancer Biology (University of Illinois) Postdoctoral Associate – Mammary Stem Cell and Cancer Biology (University of Miami) Assistant Professor – Molecular Therapeutics of Cancer (Dartmouth College) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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