Mammary Cell News Volume 10.03 | Jan 25 2018

TOP STORY

MSK1 Regulates Luminal Cell Differentiation and Metastatic Dormancy in ER⁺ Breast Cancer

Using an in vivo genome-wide short hairpin RNA screening, scientists identified the kinase MSK1 as an important regulator of metastatic dormancy in breast cancer. In patients with ER⁺ breast cancer, low MSK1 expression associated with early metastasis. [Nat Cell Biol] Abstract | Press Release

(Ranked by impact factor of the journal)

Chemotherapy Induces Enrichment of CD47⁺/CD73⁺/PDL1⁺ Immune Evasive Triple-Negative Breast Cancer Cells

Researchers showed that when triple-negative breast cancer cells are treated with chemotherapy, the surviving cells turn on genes that enable them to escape killing by the immune system. [Proc Natl Acad Sci USA] Abstract

Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Post-Translational Downregulation of c-Flip

The authors identified a specific post-translational modification that occurs during endocrine resistance and which results in tumor susceptibility to the apoptosis inducer TNF-related apoptosis-inducing ligand (TRAIL). [Clin Cancer Res] Abstract

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival

Scientists report the engineering of a nanoparticle-based RNAi therapeutic that can effectively silence the mTORC2 obligate cofactor Rictor. Nanoparticle-based Rictor ablation in HER2-amplified breast tumors was achieved following intra-tumoral and intra-venous delivery, decreasing Akt phosphorylation and increasing tumor cell killing. [Cancer Res] Abstract

ERα-Mediated Nuclear Sequestration of RSK2 Is Required for ER⁺ Breast Cancer Tumorigenesis

Using multiple in vitro and in vivo models of ER⁺ breast cancer, researchers report that ERα sequesters active ribosomal S6 kinase 2 (RSK2) into the nucleus to promote neoplastic transformation and facilitate metastatic tumor growth. [Cancer Res] Abstract

LIPG Signaling Promotes Tumor Initiation and Metastasis of Human Basal-Like Triple-Negative Breast Cancer

Scientists demonstrated that endothelial lipase (LIPG) is required for in vivo tumorigenicity and metastasis of triple-negative breast cancer cells. [Elife] Full Article

FYN Promotes Mesenchymal Phenotypes of Basal Type Breast Cancer Cells through STAT5/NOTCH2 Signaling Node

Investigators report that FYN among SRC family kinases is required for the maintenance of basal type breast cancer subtype. FYN enhanced NOTCH2 activation in basal type breast cancer cells through STAT5-mediated upregulation of Jagged-1 and DLL4 NOTCH ligands, thereby contributed to mesenchymal phenotypes. [Oncogene] Abstract

Network Analysis of SRC-1 Reveals a Novel Transcription Factor Hub Which Regulates Endocrine Resistant Breast Cancer

The authors took a top-down discovery approach to map out the steroid receptor coactivator 1 (SRC-1) transcriptional network in endocrine resistant breast cancer. [Oncogene] Full Article

Podoplanin Regulates Mammary Stem Cell Function and Tumorigenesis by Potentiating Wnt/β-Catenin Signaling

Researchers identified the transmembrane protein, podoplanin (Pdpn), as a specific marker of the basal compartment, including multipotent stem cells, and found Pdpn localized at the basal-luminal interface. [Development] Abstract

Systems Modeling Accurately Predicts Responses to Genotoxic Agents and Their Synergism with BCL-2 Inhibitors in Triple Negative Breast Cancer Cells

The authors determined whether a deterministic systems model of BCL2 protein interactions, DR_MOMP predicts responses of triple negative breast cancer cells to genotoxic agents and the re-sensitization of resistant cells by BCL2 inhibitors. [Cell Death Dis] Full Article

U-Box Ubiquitin Ligase PPIL2 Suppresses Breast Cancer Invasion and Metastasis by Altering Cell Morphology and Promoting SNAI1 Ubiquitination and Degradation

Researchers demonstrated that PPIL2 suppressed metastasis in a breast cancer model by altering cell morphology and suppressing the epithelial-mesenchymal transition process. [Cell Death Dis] Full Article

Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer

The authors focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. They delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

New Johns Hopkins Center Aims to Unlock Genetic Mysteries of Breast Cancer

With National Cancer Institute grant, researchers merge biology with applied mathematics. [Johns Hopkins University] Press Release

Synthon’s [Vic-]Trastuzumab Duocarmazine (SYD985) Granted FDA Fast Track Designation for Pre-Treated HER2-Positive Metastatic Breast Cancer

Synthon Biopharmaceuticals announced that the FDA has granted Fast Track designation for its investigational anti-HER2 antibody-drug conjugate [vic-]trastuzumab duocarmazine. [Synthon Biopharmaceuticals] Press Release

German Scientists Hope for Windfall from Incoming Government

Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial

Nobel Laureate Suggests He Could Fall on Sword over Colleague’s Bogus Paper

Shinya Yamanaka, who won a share of the 2012 Noble Prize in Physiology or Medicine for the discovery of induced pluripotent stem (iPS) cells, has suggested he could resign as director of Kyoto University’s Center for iPS Cell Research and Application in Japan over a fraudulent paper published by center researchers. [ScienceInsider] Editorial

NEW Annual Meeting of the Israel Stem Cell Society 2018
May 31, 2018
Tel Aviv, Israel

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Cancer Molecular Genetics and Therapeutics (Massachusetts General Cancer Center)

NEW Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

NEW Postdoctoral Research Associate – Cancer Biology (King’s College London)

NEW Postdoctoral Researcher – Development of Novel Cancer Therapies (University of Oxford)

Cancer Bioinformatician – Breast Cancer Research (The Institute of Cancer Research)

Scientific Officer – Breast Cancer Research (The Institute of Cancer Research)

Higher Scientific Officer – Breast Cancer Research (The Institute of Cancer Research)

Postdoctoral Associate – Breast Cancer Research (University of Miami)

Postdoctoral Fellowship – Breast Cancer Research (Geisel School of Medicine at Dartmouth)

Postdoctoral Position – Transcriptomics and Cancer Epigenetics (Universität Basel)

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