Mammary Cell News 10.26 July 5, 2018 | |
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TOP STORYTargeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling Researchers showed that mesenchymal-like (M)- and epithelial-like (E)-breast cancer stem cells (BCSCs) rely on distinct metabolic pathways and display markedly different sensitivities to inhibitors of glycolysis and redox metabolism. Metabolic or oxidative stress generated by 2DG, H2O2, or hypoxia promoted the transition of ROSlo M-BCSCs to a ROShi E-state. [Cell Metab] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Rh(III) complex 1 was identified as a direct, selective and potent inhibitor of KDM5A that directly abrogated KDM5A demethylase activity via antagonizing the KDM5A‐tri‐/di‐methylated histone 3 protein‐protein interaction in vitro and in cellulo. [Angew Chem Int Ed Engl] Abstract Expression of Long Non-Coding RNA YIYA Promotes Glycolysis in Breast Cancer Scientists reported that upregulation of the long non-coding RNA LINC00538 (YIYA) promoted glycolysis, cell proliferation and tumor growth in breast cancer. YIYA associated with the cytosolic cyclin-dependent kinase CDK6 and regulated CDK6-dependent phosphorylation of the fructose bisphosphatase PFK2 in a cell cycle-independent manner. [Cancer Res] Abstract Investigators showed that macroH2A1.2, one of the macroH2A isoforms, has an intrinsic ability to inhibit breast cancer-derived osteoclastogenesis. This repressive effect required macroH2A1.2-dependent attenuation of expression and secretion of lysyl oxidase in breast cancer cells. [Cell Rep] Full Article | Graphical Abstract The authors found that BGJ398, an FGFR inhibitor, effectively inhibited phosphorylation of FGFR1 and MEK/ERK signaling in FGFR1-amplified breast cancer without affecting tumor cell proliferation. They found that FGF-FGFR1 signaling induced an autocrine activation of vascular endothelial growth factor (VEGF)-VEGFR1 pathway that again amplified VEGF secretion via VEGF-VEGFR1-AKT signaling. [Oncogene] Abstract VEGF‐knocked‐out MDA‐MB‐231 cells (231VEGFKOex3) showed rounded morphology and shorter perimeter. 231VEGFKOex3 cells also showed impaired cell migration. Genome‐wide gene expression profiling identified ARHGAP17 as one of the target genes downstream of the VEGF/NRP1 signal. [Int J Cancer] Abstract Downregulation of lncRNA GAS5 Confers Tamoxifen Resistance by Activating miR-222 in Breast Cancer Researchers found that growth arrest-specific transcript 5 (GAS5) overexpression enhanced cell sensitivity to tamoxifen in MCF-7R cells both in vitro and in vivo. GAS5 increased sensitivity of breast cancer cells to tamoxifen by serving as a molecular sponge for miR-222, contributing to suppression of phosphatase and tensin homologs (one endogenous target of miR-222). [Cancer Lett] Abstract Scientists found that miR-205 expression level was extremely low in basal mesenchymal-like highly migratory and invasive triple negative breast cancer (TNBC) cells. Stably re-expressing miR-205 in TNBC cells significantly reduced their migration, invasion capability and cancer stem cell-like property. [Cancer Lett] Abstract MiR-133b Targets Sox9 to Control Pathogenesis and Metastasis of Breast Cancer The authors identified Sox9, c-MET, and WAVE2 as direct targets of miR-133b, in which Sox9 contributed to all miR-133b-endowed effects including cell proliferation, colony formation, as well as cell migration and invasion in vitro. Re-expression of Sox9 reversed miR-133b-mediated metastasis suppression in vivo. [Cell Death Dis] Full Article FOXP3 Inhibits Angiogenesis by Downregulating VEGF in Breast Cancer Expression of vascular endothelial growth factor (VEGF) was downregulated by forkhead box P3 (FOXP3) in breast cancer cell lines. Investigators demonstrated that FOXP3 could directly interact with the VEGF promoter via specific forkhead-binding motifs to suppress its transcription. [Cell Death Dis] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSEpithelial-to-Mesenchymal Transition and Cancer Stem Cells Contribute to Breast Cancer Heterogeneity Understanding breast cancer heterogeneity is necessary to develop preventive interventions and targeted therapies. The authors summarize the current understanding of breast cancer heterogeneity, links between epithelial‐to‐mesenchymal transition (EMT) and cancer stem cells, regulation of EMT by Runx transcription factors, and potential therapeutic strategies targeting these processes. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSLynparza Approved in Japan for BRCA-Mutated Metastatic Breast Cancer AstraZeneca and Merck & Co., Inc., announced that Japan’s Pharmaceuticals and Medical Devices Agency has approved Lynparza tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 negative breast cancer who have received prior chemotherapy. [AstraZeneca] Press Release Genentech, announced that the Phase III IMpassion130 study met its co-primary endpoint of progression free survival. [Genentech, Inc.] Press Release BioAtla, LLC, announced the treatment of the first patient in its clinical trial BA3021-001 for BioAtla’s BA3021, a novel conditionally active ROR2-targeted antibody-drug conjugate (CAB-ROR2-ADC). [BioAtla® LLC (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSHidden Conflicts? Pharma Payments to FDA Advisers after Drug Approvals Spark Ethical Concerns In examining compensation records from drug companies to physicians who advised FDA on whether to approve 28 psychopharmacologic, arthritis, and cardiac or renal drugs between 2008 and 2014, Science found widespread after-the-fact payments or research support to panel members. The agency’s safeguards against potential conflicts of interest are not designed to prevent such future financial ties. [ScienceInsider] Editorial A Better Measure of Research from the Global South Funders Jean Lebel and Robert McLean describe a new tool for judging the value and validity of science that attempts to improve lives. [Nature News] Editorial University of Gothenburg Moves to Fire Professor for Misconduct The University of Gothenburg has taken steps to remove Suchitra Sumitran-Holgersson from her post as a professor there, after an investigation concluded that she manipulated images in seven out of 10 papers. [The Scientist] Editorial Hungarian Academy to Draw Up Alternative Research Budget The Hungarian Academy of Sciences is set to put forward an “alternative proposal” for the country’s research budget, after the government moved to put the Ministry of Innovation and Technology in charge of financing research institutions, seen as the latest attack on sector autonomy by the authoritarian Orbán administration. [Times Higher Education] Editorial
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EVENTSNEW 8th International Breast Cancer Prevention Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Breast Cancer (University of Trento) Clinical Research Scientist – Oncology Medical Affairs Breast Cancer (Lilly) Cancer Faculty Investigators – Basic & Translational Cancer Research (The University of Alabama) Postdoctoral Fellow – Molecular Mechanisms of Breast & Colon Cancers (Dalhousie University) Post-doctoral Fellow – Ovarian and Breast Cancers (John Hopkins University) Postdoctoral Research Associate – Breast Cancer (Howard University) Cancer Scientists – Breast Cancer Research (Qatar Biomedical Research Institute) Postdoctoral Position – Ovarian and Breast Cancer Research (Indiana University School of Medicine) Postdoctoral Position – Breast Cancer Research (Northwestern University) Postdoctoral Posion – Basic & Translational Breast Cancer Research (Northwestern University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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