Asymmetric Segregation of the Double-Stranded RNA Binding Protein Staufen2 during Mammalian Neural Stem Cell Divisions Promotes Lineage Progression Researchers found that knockdown of Staufen2 stimulated differentiation and overexpression produces periventricular neuronal masses, demonstrating its functional importance for normal cortical development. [Cell Stem Cell] Abstract Positional Differences of Axon Growth Rates Between Sensory Neurons Encoded by Runx3 Scientists demonstrated the molecular mechanism of another layer of complexity in vertebrates by defining a transcriptional program underlying growth differences between positionally different neurons. [EMBO J] Abstract Aβ Alters the Connectivity of Olfactory Neurons in the Absence of Amyloid Plaques In Vivo Researchers demonstrated that the connectivity of the peripheral olfactory neural circuit is perturbed in mice overexpressing human Swedish Mutation before the onset of plaques. [Nat Commun] Abstract A Role of KLF4 in Neurogenesis and Radial Neuronal Migration in the Developing Cerebral Cortex Scientists showed that kruppel-like factor 4 (KLF4) regulates neurogenesis and radial migration of neurons in the developing cerebral cortex. [Mol Cell Biol] Abstract Substrate Topography and Size Determines the Fate of Human Embryonic Stem Cells to Neuronal or Glial Lineage Investigators hypothesized that substrate topography can modulate the neural fate of human embryonic stem cells and enhance the efficiency of differentiation. [Acta Biomater] Abstract The Generation of Definitive Neural Stem Cells from PiggyBac Transposon Induced Pluripotent Stem Cells Can be Enhanced by Induction of the NOTCH Signaling Pathway Researchers discovered that the induction of the NOTCH pathway by delta-like ligand 4 improved the generation and quality of definitive neural stem cells (NSCs) while maintaining NSC specific gene expression. [Stem Cells Dev] Abstract Three-Dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro Scientists evaluated the migration and invasion capability of glioblastoma cells on and in collagen type I upon irradiation with X-rays or carbon ions. [Int J Radiat Oncol Biol Phys] Abstract Passive Immunization with Tenascin-R (TN-R) Polyclonal Antibody Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury in Rats Investigators report on rabbit-derived TN-R polyclonal antibody, which acted as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sprouting of rat cortical neurons cultured on an inhibitory TN-R substrate in vitro. [Neurosci Lett] Abstract |