CURRENT PUBLICATIONS
CD99 Inhibits Neural Differentiation of Human Ewing Sarcoma Cells and Thereby Contributes to Oncogenesis This study indicates a new role for CD99 in preventing neural differentiation of Ewing sarcoma (EWS) cells and suggests that blockade of CD99 or its downstream molecular pathway may be a new therapeutic approach for EWS. [J Clin Invest]
Genomic Code for Sox10 Activation Reveals a Key Regulatory Enhancer for Cranial Neural Crest In search of direct inputs to the neural crest specifier module, researchers dissected the chick Sox10 genomic region and isolated two downstream regulatory regions with distinct spatiotemporal activity. [Proc Natl Acad Sci U S A]
The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity In Vitro and In Vivo To discover other downstream targets of neurofibromin, researchers performed an unbiased cell-based high-throughput chemical library screen using NF1-deficient malignant peripheral nerve sheath tumor cells. [Cancer Res]
Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord Researchers demonstrate key biological and functional benefits for the combined use of chondroitinase ABC, growth factors, and neural stem/progenitor cells to repair the chronically injured spinal cord. [ J Neurosci]
Increased Neural Progenitors in Vascular Dementia An immunohistological study was performed in order to examine neurogenesis in both the subventricular and peri-infarct zones of vascular dementia patients compared to age-matched controls. [Neurobiol Aging]
Gliomas Display a MicroRNA Expression Profile Reminiscent of Neural Precursor Cells Both human gliomas (regardless of their grade) and methylcholanthrene-induced mouse glioma shared an miRNA expression profile that is reminiscent of neural precursor cells. [Neuro Oncol]
Neural Crest Cell Origin and Signals for Intrinsic Neurogenesis in the Mammalian Respiratory Tract Researchers investigate the innervation of the respiratory tract during mouse embryonic development with a focus on identification of cell origin and essential developmental signals for the resident, or intrinsic, neurons. [Am J Respir Cell Mol Biol]
A Multipotent Neural Crest Derived Progenitor Cell Population is Resident within the Oral Mucosa Lamina Propria This paper reports for the first time, the isolation and characterisation of a novel, clonally derived progenitor cells population resident within the oral mucosal lamina propria. [Stem Cells Dev]
Stem Cells from Human Exfoliated Deciduous Teeth Can Differentiate into Dopaminergic Neuron-Like Cells Results indicate that stem cells from human exfoliated deciduous teeth, potentially derived from neural crest cells, may be an optimal source of postnatal stem cells for Parkinson’s disease treatment. [Stem Cells Dev]
Delta Opioid Peptide DADLE and Naltrexone Cause Cell Cycle Arrest and Differentiation in a Central Nervous System Neural Progenitor Cell Line This study examined the effect of a stable delta opioid peptide [D-Ala(2), D-Leu(5)]-enkephalin (DADLE) on proliferation and differentiation in an AF5 central nervous system neural progenitor cell line derived from rat mesencephalic cells. [Synapse]
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POLICY NEWS
Senate Rejects Stem Cell Legislation By a vote of 21 to 12, the South Dakota Senate shot down a bill that could have repealed South Dakota’s ban on embryonic stem cell treatments. [South Dakota Senate, United States]
Parsing National Institutes of Health’s 2011 Budget: Is Big Science Up, Small Science Down? Is National Institutes of Health Director Francis Collins planning to steer his ocean liner of an institute toward “big biology” at the expense of single-investigator grants? [National Institutes of Health, United States]
Medvedev Talks Science in Moscow Russian science has been getting some bad press recently, what with a recent report on its declining productivity in scientific papers and a letter from expatriate scientists to the Russian president and prime minister warning of the parlous state of basic research. [Russian Academy of Sciences, Russia]
Impersonation of MHRA Staff [Medicines and Healthcare Products Regulatory Agency, United Kingdom]
Waivers for Conflicts of Interest for the February 22, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]
Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]
Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States]
IACUC 101 Workshop and PRIM&R 2010 IACUC Conference: March 21-23, 2010 in Baltimore, MD (NOT-OD-10-059) [National Institutes of Health, United States]
Delays in Grant Application Submission Due to Blizzard (NOT-OD-10-060) [National Institutes of Health, United States]
Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]
Notice of Availability of Administrative Supplements for R25 Science Education Grants (NOT-DA-10-007) [National Institutes of Health, United States]
Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Heart, Lung, and Blood Institute, United States]
Neurotechnology Research, Development, and Enhancement – [SBIR (R43/R44)] [Small Business Innovation Research, United States]
Neurotechnology Research, Development, and Enhancement – [STTR (R41/R42)] [Small Business Technology Transfer, United States]
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EVENTS
Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4) February 15-20, 2010 Keystone, United States
American Society for Neurochemistry (ASN) 41st Annual Meeting March 6-10, 2010 Santa Fe, United States
American Association for Cancer Research (AACR) 101st Annual Meeting 2010 April 17-21, 2010 Washington, DC, United States
17th Annual Conference of the American Society for Neural Therapy & Repair (ASNTR) April 29-May 1, 2010 Clearwater Beach, United States
2010 Canadian Neuroscience Meeting May 15-18, 2010 Ottawa, Canada
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States
BIT’s 1st World Congress of NeuroTalk – 2010 June 25-28, 2010 Singapore, Singapore
7th Federation of European Neuroscience Societies (FENS) Forum of European Neuroscience July 3-7, 2010 Amsterdam, The Netherlands
40th Annual Meeting of the Society for Neuroscience 2010 November 13-17, 2010 San Diego, United States
JOB OPPORTUNITIES
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