In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry Researchers developed an adeno-associated virus-based reporter system that allows selective GFP labeling of reprogrammed neurons. In this system, GFP is turned on only in reprogrammed neurons where it is stable and maintained for long time periods, allowing for histological and functional characterization of mature neurons. [Cell Rep] Full Article | Graphical Abstract Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation with Cortical Neurons: The Role of Crosstalk between Cells The intercellular communications of mesenchymal multipotent stromal cells (MMSCs) and neuronal cells were studied in vitro. As a result of cocultivation of MMSCs and rat cortical neurons, scientists proved the existence of intercellular contacts providing transfer of cellular contents from one cell to another. [Stem Cells Transl Med] Abstract Alpha-Synuclein Affects Neurite Morphology, Autophagy, Vesicle Transport and Axonal Degeneration in CNS Neurons The authors examined the effects of overexpression of human wildtype alpha-synuclein (αSyn-WT), a protein associated with Parkinson disease, and its mutant variants αSyn-A30P and -A53T on neurite morphology and functional parameters in rat primary midbrain neurons. [Cell Death Dis] Full Article MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del Investigators carried out microRNA expression profiling on neurons generated from induced pluripotent stem cells derived from controls and schizophrenia patients with 22q11.2 del. [PLoS One] Full Article MicroRNA-132 Aggravates Epileptiform Discharges via Suppression of BDNF/TrkB Signaling in Cultured Hippocampal Neurons Investigators found a dramatic upregulation of microRNA-132 and brain-derived neurotrophic factor (BDNF) mRNA in the hippocampal neuronal culture model of status epilepticus obtained by Mg2+-free treatment. [Brain Res] Abstract Cold-Inducible RNA-Binding Protein Inhibits Neuron Apoptosis through the Suppression of Mitochondrial Apoptosis The authors investigated the molecular mechanisms by which cold-inducible RNA-binding protein protects the nervous system during mild hypothermia. Rat cortical neurons were isolated and cultured in vitro under mild hypothermia. [Brain Res] Abstract NKCC1 Downregulation Induces Hyperpolarizing Shift of GABA Responsiveness at Near Term Fetal Stages in Rat Cultured Dorsal Root Ganglion Neurons Gramicidin-perforated patch-clamp recordings were used to assess the developmental change in chloride homeostasis in rat cultured small dorsal root ganglion neurons at the embryonic day 16 and 19. [BMC Neurosci] Full Article Rejuvenation of MPTP-Induced Human Neural Precursor Cell Senescence by Activating Autophagy Researchers used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to treat neural precursor cells derived from human embryonic stem cell line H9 and investigated related molecular mechanisms involved in this process. [Biochem Biophys Res Commun] Abstract The Effects of Okra (Abelmoschus esculentus Linn) on the Cellular Events Associated with Alzheimer’s Disease in a Stably Expressed HFE Neuroblastoma SH-SY5Y Cell Line Treatment of H63D HFE cells either with okra or quercetin significantly decreased reactive oxygen species, hydrogen peroxide, and protein oxidation compared to untreated cells. The levels of tau phosphorylation at serine-199, serine-202, and serine-396 sites were also significantly decreased when cells were treated with okra. [Neurosci Lett] Abstract |