Zbtb20 Promotes Astrocytogenesis during Neocortical Development Investigators showed that Zbtb20 regulates astrocyte specification in the mouse neocortex. Zbtb20 is highly expressed in late-stage neural precursor cells and their astrocytic progeny. [Nat Commun] Full Article A Subcutaneous Cellular Implant for Passive Immunization against Amyloid-β Reduces Brain Amyloid and Tau Pathologies When encapsulated cells were implanted before the onset of amyloid plaque deposition in TauPS2APP mice, chronic exposure to anti-amyloid-β antibodies dramatically reduced amyloid-β40 and amyloid-β42 levels in the brain, decreased amyloid plaque burden, and most notably, prevented phospho-tau pathology in the hippocampus. [Brain] Full Article | Video | Press Release Alternative Splicing of G9a Regulates Neuronal Differentiation The authors found that the G9a methyltransferase is required for differentiation of the mouse neuronal cell line N2a and that exon 10 inclusion increases during neuronal differentiation of cultured cells, as well as in the developing mouse brain. [Cell Rep] Full Article | Graphical Abstract Differential Response of Patient-Derived Primary Glioblastoma Cells to Environmental Stiffness Scientists compared the rigidity-response of primary patient-derived glioblastoma lines. Cells were plated on polyacrylamide gels of defined rigidity that reflect the diversity of the brain tissue mechanical environment, and cell morphology and migration were analyzed by time-lapse microscopy. [Sci Rep] Full Article The miR-20-Rest-Wnt Signaling Axis Regulates Neural Progenitor Cell Differentiation Researchers screened the differential expression patterns of miRNAs between two dimensional cultured and three dimensional cultured neural progenitor cells (NPCs) using microarray analysis. Among these differentially expressed miRNAs, miR-20 was found to increase during differentiation of NPCs. [Sci Rep] Full Article Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells Cell-derived motor neurons mimicked several neurodegenerative phenotypes including mis-localization of fused-in sarcoma (FUS) into cytosolic and stress granules under stress conditions, and cellular vulnerability. [Stem Cell Reports] Full Article | Graphical Abstract Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1 Using wheat-germ agglutinin-based transsynaptic tracing, the authors showed that integrin α5 is selectively expressed in striatal neurons that are innervated by midbrain dopaminergic neurons. [Stem Cell Reports] Full Article | Graphical Abstract Using Primate Neural Stem Cells Cultured in Self-Assembling Peptide Nanofiber Scaffolds to Repair Injured Spinal Cords in Rats Neural stem cells (NSCs) and NSCs cultured in self-assembling peptide nanofiber scaffolds could be induced to differentiate into neurons, glial cells and oligodendrocytes in vitro. [Spinal Cord] Abstract |