CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Conversion of Vascular Endothelial Cells into Multipotent Stem-Like Cells Here, researchers show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2 receptor-dependent mechanism. [Nat Med] Fus-Chop Fusion Protein Expression Coupled to P53 Deficiency Induces Liposarcoma in Mouse but not Human Adipose-Derived Mesenchymal Stem/Stromal Cells Human sarcomas have been modeled in mice by expression of specific fusion genes in mesenchymal stem cells (MSCs). However, sarcoma models based on human MSCs are still missing. Researchers attempted to develop a model of liposarcoma by expressing FUS-CHOP, a hallmark mixoid liposarcoma-associated fusion oncogene, in wild-type and p53-deficient mouse and human adipose-derived mesenchymal stem/stromal cells. [Stem Cells] Enrichment of Human ESC-Derived Multipotent Mesenchymal Stem Cells with Immunosuppressive and Anti-Inflammatory Properties Capable to Protect Against Experimental Inflammatory Bowel Disease Researchers report an efficient enrichment of mesenchymal stem cells from human embryonic stem cells (ESCs) through specific inhibition of SMAD-2/3 signaling. [Stem Cells] A Non-Human Primate Model for Urinary Bladder Regeneration Utilizing Autologous Sources of Bone Marrow Derived Mesenchymal Stem Cells Researchers postulated that mesenchymal stem cells could provide a cell source for partial bladder regeneration in a newly described non-human primate bladder (baboon) augmentation model. [Stem Cells] Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture Researchers report the development of hydrogel based multifunctional matrices that not only provide three-dimensional structural support to the embedded cells but also can simultaneously provide potentially beneficial dynamic mechanical and electrical cues to the cells. [Adv Funct Mater] Urokinase Receptor Mediates Mobilization, Migration and Differentiation of Mesenchymal Stem Cells Multipotent mesenchymal stem cells (MSCs) have regenerative properties and are recognized as putative players in the pathogenesis of cardiovascular diseases. The study was designed to elucidate a probable role for the multifunctional urokinase/urokinase receptor system in MSC regulation. [Cardiovasc Res] Effects of Human Mesenchymal Stem Cells on ER-Positive Human Breast Carcinoma Cells Mediated through ER-SDF-1/CXCR4 Crosstalk Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of carcinoma and affect biological processes, including tumor growth and metastasis. Previous findings have been conflicting and a clear understanding of the effects of hMSCs on cancer remains to be established. Therefore, researchers set out to investigate the impact of hMSCs on the estrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7. [Mol Cancer] Dormant Phase and Multinuclear Cells: Two Key Phenomena in Early Culture of Murine Bone Marrow Mesenchymal Stem Cells Here, researchers followed mouse bone marrow mesenchymal stem cells for more than 1 year after isolation and examined the effect of expansion on changes in morphology, growth kinetics, plasticity and chromosomal structure during in vitro culture. [Stem Cells Dev]
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INDUSTRY NEWS CaridianBCT Collaborates with CASCADE Consortium CaridianBCT announced its collaboration agreement with the Cultivated Adult Stem Cell Alternative for Damaged tissuE (CASCADE) consortium, a European Union project consisting of 16 organizations, to continue the development of culturing adult stem cells for clinical applications. [CaridianBCT Press Release] Stratophase Collaborates with LGC on Real-Time Monitoring of 3D Cell Culture Growth By using Stratophase’s innovative SpectroSens insertion probe, LGC has demonstrated its potential to improve the monitoring of cell growth in a 3D culture by enabling real-time measurement of nutrient metabolism and the build-up of waste products. [Stratophase Limited Press Release]
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EVENTS (Listed by Date) Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium: Stem Cells – Hopes, Fears and Realities December 1-3, 2010 Berlin, Germany 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference December 5-8, 2010 Orlando, United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States The American Society for Cell Biology 50th Annual Meeting December 11-15, 2010 Philadelphia, United States Pharmacology in Stem Cells Research and Regenerative Medicine December 17, 2010 London, United Kingdom The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine December 17-19, 2010 Guangzhou, China Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition January 21-26, 2011 Vancouver, Canada 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, D.C., United States Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States Stem Cell Research Forum of India 2nd Annual Meeting February 8-11, 2011 Bangalore, India 1st Annual Clinical Meeting of the Cell Society February 18-19, 2011 La Jolla, United States NEW SMi Stem Cells 2011 – Innovation & Commercialisation February 23-24, 2011 London, United Kingdom 6th Annual Stem Cell Summit March 1, 2011 New York, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Stem Cells, Cancer and Metastasis March 6-11, 2011 Dillon, United States 15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications March 16-19, 2011 Hilton Head Island, United States StemCONN 11 March 22, 2011 Farmington, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference June 7-10, 2011 Granada, Spain International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011) August 3-5, 2011 Singapore Adult MSC2011 Innovations in Cell-Based Regenerative Therapies August 22-24, 2011 Cleveland, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies) Lab Technologist – Tissue Culture (STEMCELL Technologies) Product Manager – Pluripotent Stem Cells (STEMCELL Technologies) Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Mesenchymal Cell News at no cost. Visit here to post your career opportunities.
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