The Effects of Graphene Nanostructures on Mesenchymal Stem Cells Researchers report the effects of two-dimensional graphene nanostructures; graphene nano-onions, graphene oxide nanoribbons, and graphene oxide nanoplatelets on viability, and differentiation of human mesenchymal stem cells. [Biomaterials] Abstract | Video Regeneration of Human-Ear-Shaped Cartilage by Co-Culturing Human Microtia Chondrocytes with BMSCs Scientists demonstrated that microtia chondrocytes (MCs) possessed strong proliferation ability but accompanied with rapid loss of chondrogenic ability during passage, indicating a poor feasibility to engineer the entire ear using expanded MCs. [Biomaterials] Abstract Hepatocyte Growth Factor and p38 Promote Osteogenic Differentiation of Human Mesenchymal Stem Cells Researchers report that hepatocyte growth factor promotes osteogenic differentiation through the transcription of key osteogenic markers, including Osteocalcin, Osterix, and Osteoprotegerin in human mesenchymal stem cells and is a necessary component for the establishment of osteoblast mineralization. [Mol Endocrinol] Abstract Osteogenesis from Human Induced Pluripotent Stem Cells: an In Vitro and In Vivo Comparison with Mesenchymal Stem Cells Osteo-induced human induced pluripotent stem cells were implanted on the critical-size calvarial defects and long bone segmental defects in rats. The healing of defects was evaluated after 8 weeks and 12 weeks of implantation respectively. [Stem Cells Dev] Abstract Generation of 3D Functional Microvascular Networks with Human Mesenchymal Stem Cells in Microfluidic Systems Scientists investigated the role played by two endothelium-related molecules, angiopoietin and transforming growth factor, on bone marrow-derived human mesenchymal stem cell phenotypic transition toward a mural cell lineage, both in monoculture and in direct contact with human endothelial cells, within 3D fibrin gels in microfluidic devices. [Integr Biol] Abstract Taurine Promotes Human Mesenchymal Stem Cells to Differentiate into Osteoblast through the ERK Pathway Investigators showed that taurine increased the alkaline phosphatase activity and mineralized nodules in human mesenchymal stem cells induced by osteogenic induced medium. [Amino Acids] Abstract Multipotential Stromal Cell Abundance in Cellular Bone Allograft: Comparison with Fresh Age-Matched Iliac Crest Bone and Bone Marrow Aspirate Scientists enumerated and characterized multipotential stromal cells in a cellular bone allograft and compare with fresh age-matched iliac crest bone and bone marrow aspirate. [Regen Med] Full Article Repeated Lipopolysaccharide Stimulation Promotes Cellular Senescence in Human Dental Pulp Stem Cells (DPSCs) DPSCs were stimulated with lipopolysaccharide and senescence was evaluated by senescence-associated ß-galactosidase staining, with cell number and cell-cycle arrest being examined by BrdU assay and flow cytometry, respectively. [Cell Tissue Res] Abstract Epigallocatechin-3-Gallate (EGCG) as a Pro-Osteogenic Agent to Enhance Osteogenic Differentiation of Mesenchymal Stem Cells from Human Bone Marrow: An In Vitro Study The osteogenic effects of EGCG were studied in primary human bone-marrow-derived mesenchymal stem cells by detecting cell proliferation, alkaline phosphatase activity and the expression of relevant osteogenic markers. [Cell Tissue Res] Abstract Estrogen as a Novel Agent for Induction of Adipose-Derived Mesenchymal Stem Cells for Osteogenic Differentiation: In Vivo Bone Tissue-Engineering Study Scientists investigated whether the in vivo osteogenic differentiation potential of adipose-derived mesenchymal stem cells is enhanced by 17ß-estradiol. [Plast Reconstr Surg] Abstract |