Melatonin Enhances the Human Mesenchymal Stem Cells Motility via Melatonin Receptor 2 Coupling with Gαq in Skin Wound Healing In a mouse skin excisional wound model, scientists found that transplantation of umbilical cord blood mesenchymal stem cells (UCB-MSCs) pre-treated with melatonin enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites, where relatively more UCB-MSCs which were engrafted onto the wound site were detected. [J Pineal Res] Abstract TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells Using fluorescence and laser confocal microscopy as well as patch clamp techniques, investigators identified the transient receptor potential melastatin type 7 (TRPM7) channel as the key channel involved in mechanotransduction in bone marrow mesenchymal stem cells. [Stem Cells] Abstract Mesenchymal Stem Cells with Increased SDF-1 Expression Enhanced Fracture Healing In a rat defect bone model, bone marrow mesenchymal stem cells over-expressing SDF-1 showed significantly more new bone formation within the gap and less bone mineral loss at the area adjacent to the defect site during the early bone healing stage than non-transfected cells. [Tissue Eng Part A] Abstract Impaired Endothelium-Mesenchymal Stem Cells Cross-Talk in Systemic Sclerosis: A Link Between Vascular and Fibrotic Features Scientists investigated different angiogenic and profibrotic molecules in a tridimensional matrigel assay, performing co-cultures with endothelial cells and bone marrow derived mesenchymal stem cells from patients and healthy controls. [Arthritis Res Ther] Abstract | Full Article Lithium Stimulates Human Bone Marrow-Derived Mesenchymal Stem Cell Proliferation through GSK-3-Beta-Dependent Beta-Catenin/Wnt Pathway Activation Scientists show for the first time that lithium, a well-known antidepressant, reversibly promoted the proliferation of human bone marrow-derived mesenchymal stem cells (MSC) in vitro. MSC treated with 5 mM lithium proliferated more rapidly than untreated cells without undergoing apoptosis. [FEBS J] Abstract MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF Using microRNA microarray analysis, investigators identified a microRNA expression profile in hypoxia-treated mesenchymal stem cells and observed that among all dysregulated microRNAs, microRNA-377 was decreased the most significantly. [PLoS One] Full Article Tissue-Engineered Tracheal Reconstruction Using Mesenchymal Stem Cells Seeded on a Porcine Cartilage Powder Scaffold Researchers investigated the plausibility of using mesenchymal stem cells seeded on a porcine cartilage powder scaffold for tracheal defect repair. After seven weeks culture, the tracheal implants were transplanted on a 5 × 10 mm tracheal defect in six rabbits. [Ann Biomed Eng] Abstract Fibroblast Growth Factor-2 Alone as an Efficient Inducer for Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Dopaminergic Neurons The reported efficiency of differentiation of human bone marrow derived mesenchymal stem cells (hBM-MSC) into dopaminergic neurons with different inducers is found to vary. Scientists investigated the response of hBM-MSCs to some of the neuronal inducers and their combinations. [J Biomed Sci] Abstract | Full Article |