A Novel Collagen-Nanohydroxyapatite MicroRNA-Activated Scaffold for Tissue Engineering Applications Capable of Efficient Delivery of Both miR-Mimics and antagomiRs to Human Mesenchymal Stem Cells Scientists introduced the first non-viral, non-lipid platform to date, capable of efficient delivery of mature microRNAs (miRNAs) molecules to human mesenchymal stem cells, a particularly difficult cell type to transfect effectively, with minimal treatment-associated cytotoxicity. [J Control Release] Abstract Random Networks of Single-Walled Carbon Nanotubes Promote Mesenchymal Stem Cell’s Proliferation and Differentiation The author demonstrated that the single-walled carbon nanotubes (SWCNT) Langmuir-Blodgett and network film based scaffolds do not show any cytotoxicity, while on the other hand, these scaffolds promote differentiation property of rat mesenchymal stem cells when compared with that on conventional tissue culture polystyrene substrates. [ACS Appl Mater Interfaces] Abstract Effects of Mesenchymal Stem Cell Therapy, in Association with Pharmacologically Active Microcarriers Releasing VEGF, in Ischemic Stroke Model in the Rat The effect of mesenchymal stem cell attached to laminin-pharmacologically active microcarriers, releasing or not vascular endothelial growth factor (VEGF), was evaluated in vivo in a model of transient stroke. [Acta Biomater] Abstract Systemic Mesenchymal Stem Cell Administration Enhances Bone Formation in Fracture Repair but Not Load-Induced Bone Formation Investigators questioned whether circulating mesenchymal stem cells (MSC) are recruited only in case of injury or whether they also participate in mechanically induced bone formation. To answer these questions, they injected green fluorescent protein-labelled MSC into C57BL/6J mice, which were subjected either to a femur osteotomy or to non-invasive mechanical ulna loading to induce bone formation. [Eur Cell Mater] Abstract | Full Article Influence of Culture Conditions and Extracellular Matrix Alignment on Human Mesenchymal Stem Cells Invasion into Decellularized Engineered Tissues Scientists explored the influence of insulin and ascorbic acid and extracellular matrix alignment on the recellularization of decellularized engineered tissue by human mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract Chronic Spinal Cord Lesions Respond Positively to Transplants of Mesenchymal Stem Cells Researchers investigated whether transplantation of mesenchymal stem cells in mice during the chronic stage of spinal cord injury has benefits in terms of morphological and functional outcomes. [Restor Neurol Neurosci] Abstract CCR7 Expressing Mesenchymal Stem Cells Potently Inhibit Graft-versus-Host Disease by Spoiling the Fourth Supplemental Billingham’s Tenet CCR7 gene was engineered into murine mesenchymal stem cells (MSCs) by lentivirus transfection system (MSCs/CCR7) and the immunomodulatory mechanism of MSCs/CCR7 was further investigated. [PLoS One] Full Article Comparison of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes with Human Mesenchymal Stem Cells following Acute Myocardial Infarction Researchers compared the therapeutic efficacy of human mesenchymal stem cells with human induced pluripotent stem cell-derived cardiomyocytes in mitigating myocardial infarction. [PLoS One] Full Article Role of Wnt/β-Catenin Signaling in Epithelial Differentiation of Lung Resident Mesenchymal Stem Cells Researchers explored the roles of Wnt/β-catenin signaling on cell proliferation and epithelial differentiation of lung resident mesenchymal stem cells (LR-MSCs). They also demonstrated the expression of epithelial markers on LR-MSCs following indirect co-culture of these cells with alveolar epithelial type II cells, confirming the epithelial phenotype of LR-MSCs following co-culture. [J Cell Biochem] Abstract Statins Impair Survival of Primary Human Mesenchymal Progenitor Cells via Mevalonate Depletion, NF-κB Signaling, and Bnip3 Scientists examined the in vitro effects of three HMG-CoA reductase inhibitors atorvastatin, simvastatin, and pravastatin on the viability of mesenchymal stem cells and expression of nuclear factor kappa B (NF-κB). [J Cardiovasc Transl Res] Abstract The Effect of Extended Passaging on the Phenotype and Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells Investigators assessed morphology, viability, mesenchymal stem cells (MSC) marker expression, and osteogenic activity of human umbilical cord MSCs after extended passaging. [Mol Cell Biochem] Abstract |