Mesenchymal Cell News 8.27 July 12, 2016 | |
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TOP STORYHyaluronan-coated surfaces preserve the proliferation and differentiation potential of mesenchymal stem cells by prolonging their G1-phase transit, which maintains cells in a slow-proliferative mode. The metabolic mechanism underlying the hyaluronan-regulated slow-proliferative maintenance of stem cells was investigated by evaluating mitochondrial functions. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROScientists conducted a combinatorial study of matrix properties that influence adipogenesis and neurogenesis including: adhesion proteins, stiffness, and cell geometry, for mesenchymal stem cells derived from adipose tissue and bone marrow. [Acta Biomater] Abstract Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype through α2β1 Signaling Investigators hypothesized that entrapment of mesenchymal stem cell spheroids formed from osteogenically induced cells would exhibit better preservation of their bone-forming potential than would dissociated cells from monolayer culture. [Stem Cells Transl Med] Abstract | Full Article Transcriptomic Analyses of Adipocyte Differentiation from Human Mesenchymal Stromal-Cells (MSC) Researchers investigated differential mRNA and miRNA expression patterns of human MSC induced and not induced to differentiate into adipocytes by next (second)-generation sequencing. [J Cell Physiol] Abstract Investigators used a specific experimental model in vitro, co-culturing MSC with peripheral blood mononucleated cells from normal individuals, in order to generate MSC-educated G-MDSC. [PLoS One] Full Article Scientists investigated the role of miR-9 and its mechanism on the osteoblast differentiation of mesenchymal stem cells. Real-time PCR and western blotting were used to study gene expression. [Mol Biol Rep] Abstract IN VIVOInvestigators performed a first-in-human Phase I safety clinical trial of metabolically fit autologous bone marrow-derived mesenchymal stromal cells in 12 subjects with Crohn’s disease utilizing three doses. [Aliment Pharmacol Ther] Full Article Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice Researchers demonstrated for the first time that adipose-derived mesenchymal stem cell infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice. [Stem Cells Transl Med] Abstract Scientists found that umbilical cord-derived mesenchymal stem cells reduced scar formation and myofibroblast accumulation in a skin-defect mouse model. [Stem Cells Transl Med] Abstract | |
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REVIEWSRegulatory Role of MicroRNAs in the Proliferation and Differentiation of Adipose-Derived Stem Cells The authors summarize the adipose-derived stem cells (ASC)-related miRNAs and their pivotal roles in regulating the proliferation and differentiation of ASCs. [Histol Histopathol] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
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INDUSTRY NEWSFirst Patient Is Randomized in STEMTRA Trial for Traumatic Brain Injury SanBio, Inc. announced the randomization of the first patient in the STEMTRA Phase II clinical trial study for traumatic brain injury. The STEMTRA “Stem cell therapy for traumatic brain injury” trial will examine the effects of SB623 stem cell treatment in patients with chronic motor deficits resulting from traumatic brain injury. SB623 cells are modified allogeneic mesenchymal stem cells, derived from the bone marrow of healthy human adult donors. [SanBio, Inc. (Business Wire)] Press Release Regeneus Ltd on Track for Japanese Commercial Partnership Agreement Regeneus Ltd is on track to enter its first significant partnering agreement in Japan for its stem cell product, Progenza. Progenza is an off-the-shelf stem cell product with the first targeted treatment being for knee osteoarthritis. [Regeneus Ltd] Press Release | |
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POLICY NEWSFDA Should Stand Firm on Stem-Cell Treatments You may have heard that regulators in the United States are too strict when it comes to stem-cell treatments. The assumption in these accusations — that these treatments work — is at the heart of the problem. The FDA is right to insist that only proper clinical trials can make that case. [Nature News] Editorial House Panel Would Give NIH a 4% Raise to $33 Billion The National Institutes of Health (NIH) is slated to receive a $1.25 billion increase, to $33.3 billion, in a proposed spending measure released by a House of Representatives spending panel. That 4% boost is good news for an agency that has been flat funded for a decade, although it falls short of a 6% raise approved by a Senate panel. [Nature News] Editorial | Press Release Canada’s Health Funder Agrees to Meet with Researchers Outraged by Peer-Review Changes Canadian Institute of Health Research (CIHR) President Alain Beaudet said the agency will heed Jane Philpott’s request to “convene a working meeting in the very near future with key representatives of the research community, including those who have raised this issue publicly, to find common ground and move forward with solutions that address the issues raised with regard to the quality and integrity of CIHR’s peer review system.” [ScienceInsider] Editorial U.K. Research Charity Will Self-Publish Results from Its Grantees Starting sometime this fall, the Wellcome Trust will launch its own open-access online journal. Publication will be limited to the thousands of scientists worldwide working on research funded by a Wellcome grant, and it will be free not only for readers, but authors—the charity is covering the costs charged by the company that will provide the journal’s software and online platform. [ScienceInsider] Editorial Beat It, Impact Factor! Publishing Elite Turns against Controversial Metric A paper posted to the preprint server bioRxiv, authored by senior employees at several leading science publishers (including Nature’s owner, SpringerNature), calls on journals to downplay the figure in favor of a metric that captures the range of citations that a journal’s articles attract. [Nature News] Editorial | Article Brexit Watch: Scientists Grapple with the Fallout Two weeks after the United Kingdom voted to leave the European Union, the future remains opaque. Concerns within the research community are particularly intense for those who rely on the EU for funding, or who have the right to work in the United Kingdom only because they are citizens of other EU countries. [Nature News] Editorial The Past, Present and Future of the PhD Thesis According to one of those often-quoted statistics that should be true but probably isn’t, the average number of people who read a PhD thesis all the way through is 1.6. And that includes the author. More interesting might be the average number of PhD theses that the typical scientist — and reader of Nature — has read from start to finish. [Nature News] Editorial Major Funders Launch International Repository of Cutting-Edge Cancer Models U.S. and European funding agencies are launching the Human Cancer Models Initiative, which aims to give the research community tumor cells that behave more like actual human tumors. [ScienceInsider] Editorial NIH Awards $55 Million to Build Million-Person Precision Medicine Study The National Institutes of Health announced $55 million in awards in fiscal year 2016 to build the foundational partnerships and infrastructure needed to launch the Cohort Program of President Obama’s Precision Medicine Initiative. [National Institutes of Health] Press Release
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EVENTSNEW Moving Forward with Stem Cell Therapy 2016 Visit our events page to see a complete list of events in the mesenchymal cell community.
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JOB OPPORTUNITIESCell Biologist – Mesenchymal Stem Cells (Biostage) Postdoctoral Fellow – Mesenchymal Stem Cells (University of Bergen) PhD Position – Mesenchymal Stem Cells (University of Birmingham) Postdoctoral Position – Bone and Stem Cell Research (University of Connecticut Health) Professor – Cardiovascular Research (Monash University) PhD Studentship – Vascular Tissue Engineering (Trinity College Dublin) Postdoctoral Scholar – Neurobiology (Penn State College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Mesenchymal Cell News Volume 8.27 | Jul 12 2016