Mesenchymal Cell News 9.42 October 24, 2017 | |
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TOP STORYResearchers determined the provenance and function of the only population reported to exhibit thymic epithelial cell (TEC) stem cell properties in the adult, a Foxn1− EpCAM− cell that generates so-called thymospheres. They redefine the nature of bipotent TEC stem/progenitor cells in the adult thymus and highlight a potentially important mesenchymal progenitor population. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROScientists investigated if human MSCs (hMSCs), or platelet derived growth factor as produced by hMSC, could delay retinal ganglion cell death in a human retinal explant model of optic nerve injury. [Stem Cells] Abstract | Full Article A systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells. [Dent Mater] Abstract | Graphical Abstract The authors investigated the use of in vitro derived osteoblasts as a new source of feeder cells and characterized the molecular pathways that mediate their growth promoting activities. [Stem Cells Dev] Abstract A panel of five human osteosarcoma cell lines were tested. Virus oncoselectivity was confirmed by infecting non-malignant human neonatal fibroblasts and osteoblasts used as culture models of non-transformed mesenchymal cells. H-1 protoparvovirus (H-1PV) was found to enter osteosarcoma cells and to induce viral DNA replication, transcription of viral genes, and translation to viral proteins. [Viruses] Full Article Researchers investigated the effect of iRoot Fast Set root repair material on the proliferation, migration and differentiation of human dental pulp stem cells. [PLoS One] Full Article IN VIVOResearchers used ferritin gene-based magnetic resonance imaging to track the tumor tropism of MSCs in a rat orthotopic xenograft model of malignant glioma. MSCs were transduced with lentiviral vectors expressing ferritin heavy chain and enhanced green fluorescent protein. [Int J Cancer] Abstract Investigators compared the osteogenesis of human xenofree-expanded adipose tissue-derived stromal cells and adipose tissue-derived stromal cells in vitro and in an ectopic nude mouse model of bone formation. [Stem Cells Transl Med] Full Article Scientists aimed to assess engraftment, vasculogenic and pro-angiogenic activities of endothelial colony forming cells (ECFC) in immunocompetent or immunodeficient mice. The impact of host immune system was investigated where ECFC were co-implanted with mesenchymal stem/stromal cells from adult bone marrow, fetal bone marrow, fetal placental, or maternal placental. [Sci Rep] Full Article The authors showed that intraarticularly injected MSCs contribute to regeneration of articular cartilage in full-thickness cartilage defects mainly via a nonprogenitor-mediated mechanism. [JCI Insight] Full Article | |
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REVIEWSThe authors summarize the types of MSCs involved in myocardial infarction (MI) therapy, its possible mechanisms effects especially paracrine one in MI focusing on the studies (human and animal) conducted in the last ten years. [J Gene Med] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSBrainStorm Cell Therapeutics Inc. announced that it has received Notice of Allowance from the United States Patent Office. The allowed claims cover methods of treating amyotrophic lateral sclerosis and Parkinson’s disease using mesenchymal stem cells that secrete neurotrophic factors, including glial derived neurotrophic factor. [BrainStorm Cell Therapeutics Inc.] Press Release MiMedx Group, Inc. announced that the company has been notified by the FDA that its Investigational New Drug Phase IIB clinical study for osteoarthritis of the knee may proceed. [MiMedx Group, Inc.] Press Release | |
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POLICY NEWSFrench Scientists in Uproar over Changes to Medical-Research Clusters A group of French scientists is due to meet government officials in a bid to resolve a row that has left many of the country’s leading biomedical researchers furious. Scientists were shocked when the government unexpectedly postponed a call for applications to create a new crop of medical-research clusters just days before the closing date, and said that it would slash the budget earmarked for the project. [Nature News] Editorial Iranian Scholar Sentenced to Death A judge in Tehran has ordered the death penalty for Iranian researcher Ahmadreza Djalali, according to his wife and diplomatic sources in Italy. Djalali is affiliated with the Karolinska Institute in Stockholm, Sweden, and the University of Eastern Piedmont in Novara, Italy. A resident of Sweden with his family, Djalali was arrested in April 2016 on an academic visit to Tehran and accused of “collaboration with a hostile government”. [Nature News] Editorial In Brazil, Researchers Struggle to Fend Off Deepening Budget Cuts With time and money running out, Brazilian scientists are turning up the pressure on the federal government to avoid a total collapse of the national science and technology funding system before the end of the year. Researchers delivered a petition with more than 82,000 signatures to congressional leaders in BrasÃlia, demanding the reversal of deep budget cuts that have left research institutions struggling to pay even basic water and electricity bills.” [ScienceInsider] Editorial
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EVENTSNEW 6th National Congress of Bioengineering Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cardiac Recovery after Myocardial Infarction (University of Kentucky) Assistant Professor – Stem Cell And Regenerative Biology (Columbia University) Postdoctoral Researcher – Stem Cell Research (University of Helsinki) Faculty Positions – Tissue Regeneration and Engineering (Duke University) Assistant or Associate Professor – Biomedical Engineering (University of British Columbia) Researcher – Skeletal Tissue Engineering (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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