Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News| Mesenchymal Cell News 11.00 January 8, 2019 | |
 | |
| |
TOP STORYScientists showed that human myelodysplastic syndromes (MDS)-MSCs exhibit phenotypic, transcriptomic and epigenetic abnormalities. Stimuli provided by MDS-MSCs impaired the growth and function of healthy HSPCs, which was further sustained autonomously in HSPCs for significant periods of time resulting in a failure for active hematopoietic engraftment across primary and secondary transplant recipients. [Leukemia] Full Article | |
| |
| |
PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers investigated P2X7R expression in periodontal ligament stem cells (PDLSCs) under normal and inflammatory conditions and then determined the effect of a P2X7R agonist (BzATP) or antagonist (BBG) on PDLSC osteogenesis under various conditions. [Cell Death Dis] Full Article Scientists report a silk fibroin based bone tissue engineered scaffold with silver nanoparticles (AgNPs) having advanced antimicrobial properties, without compromising its cytocompatibility and stem cell differentiation potential. For this purpose, AgNPs were in situ synthesized using silk fibroin as reducing as well as stabilizing agent. [Colloids Surf B Biointerfaces] Abstract | Graphical Abstract In vitro mixed lymphocyte reaction indicated that bone marrow-derived MSCs (BMSCs)-IFN-γ inhibited T lymphocyte proliferation and activation via PD-L1. Moreover, BMSCs-IFN-γ did not influence the proliferation and activation of T lymphocytes when PD-L1 protein was neutralized by the PD-L1 antibody. [Cell Tissue Res] Abstract | Graphical Abstract Researchers found that in the process of bone marrow mesenchymal stem cells differentiation, mitochondrial length was increased, along with a decreased protein level of DLP1 and an increased protein level of OPA1 in the mitochondria, indicating a shift toward mitochondrial fusion in BMSCs during differentiation. [Exp Biol Med (Maywood)] Abstract IN VIVOResearchers showed that human gingival tissue-derived mesenchymal stem cells (GMSCs) could prevent and treat acute graft-versus-host disease in two different mouse models. The results indicated that besides exhibiting suppressive function in vitro and in vivo, GMSCs may also regulate the conversion of Tregs to Th1 and/or Th17-like cells, as well as stabilize Foxp3 expression. [Cell Death Dis] Full Article Mesenchymal Stem Cells Rejuvenate Cardiac Muscle after Ischemic Injury In vivo, transplantation of isogenic CD146+ MSCs into myocardial infarction-mice increased the proliferation of cardiac muscle cells (CMCs) and reduced apoptosis of CMCs in a significantly higher degree than transplantation of total MSCs (tMSCs), resulting in significant improvement of the heart function. In vitro, CMCs were co-cultured under hypoxia condition with CD146+MSCs or tMSCs. [Aging (Albany NY)] Full Article Scientists showed that heart function of the intervention group was significantly better than that of the control group, and the degree of fibrosis and inflammation in the intervention group were lower than those in the control group. The ratio of monocyte M1/M2 in peripheral blood, spleen and myocardial tissue in human umbilical cord blood mesenchymal stem cells transplantation was significantly lower than that of the control group. [Biomed Pharmacother] Full Article Microvesicles showed the same surface markers as MSCs but much higher miR-451a expression. miR-451a was decreased in both injured HK-2 cells and kidneys. MV-miR-451a stimulated the cell proliferation and viability in vitro and promoted structural and functional improvements of injured kidney in vivo. [Exp Biol Med (Maywood)] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
| |
| |
REVIEWSRole of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Tumour Microenvironment In this review, the authors describe the MSC-derived extracellular vesicles (EVs) content and discuss their role in different processes related to cancer biology. [Biochim Biophys Acta Rev Cancer] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
| |
INDUSTRY NEWSStemedica Cell Technologies, Inc. announced positive results from its Phase I/IIa clinical study for the treatment of ischemic stroke. [Stemedica Cell Technologies, Inc] Press Release Stem Cell Medicine Licenses Exosome Technology for Treating Autism from Ramot at Tel Aviv University Stem Cell Medicine Ltd. has licensed an innovative exosomes based technology for the treatment of neurodegenerative and neuropsychiatric indications, specifically, autism spectrum disorder. The treatment is based on vesicles, exosomes, derived from adult stem cells (MSC-exo) that are administered intranasally. [Stem Cell Medicine Ltd] Press Release FDA Accepts BrainStorm’s NurOwn® IND Application for Progressive Multiple Sclerosis BrainStorm Cell Therapeutics Inc. announced that the U.S. FDA has accepted the Investigational New Drug application to initiate a Phase II clinical trial of NurOwn® for the treatment of progressive multiple sclerosis. [BrainStorm Cell Therapeutics Inc.] Press Release | |
| |
POLICY NEWSU.S. Government Shutdown Starts to Take a Bite Out of Science The shutdown is creating chaos for university researchers, private contractors, and others who collaborate with idled federal scientists, or depend on affected agencies for funding, facilities, and data. Besides doing lasting damage to some research projects, the standstill is threatening livelihoods. [ScienceInsider] Editorial How Much Do Graduate Students Benefit From Studying Abroad? The National Science Foundation is rethinking how to provide U.S. graduate students with a chance to do science in another country. It also wants to know whether its current foreign travel programs are working. [ScienceInsider] Editorial
| |
EVENTSNEW 2nd International Translational & Regenerative Medicine Conference Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Training Fellow – Cancer Genomics (The Francis Crick Institute) NEW Postdoctoral Fellow – Lung Biology/Lung Immunology (Royal College of Surgeons in Ireland) NEW Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine) NEW Postdoctoral Fellow – Stem Cell Biology (City of Hope) NEW Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital – Harvard Medical School) NEW Post Doctoral Fellow – Stem Cell Biology (Technion – Israel Institute of Technology) Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine) Assistant Professor Positions – Department of Cardiology (Boston Children’s Hospital) Assistant Professor – Department of Biological Sciences (Rutgers University Newark) Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
