LABORATORY RESEARCH CCN3/NOV Gene Expression in Human Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through meta-analysis of microarray data, the authors nominate nephroblastoma overexpressed (NOV) as a top androgen-repressed gene. They show that NOV is directly suppressed by androgen through the androgen receptor. [Oncogene] Abstract Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice Recent evidence from a prostate regeneration assay suggests that prostate basal cells give rise to prostate cancer. Here, researchers characterized Pten-deficient prostate lesions arising from keratin 5-expressing basal cells in a temporally controlled system in mice. [Am J Pathol] Abstract Bone Marrow Mesenchymal Stem Cells Increase Motility of Prostate Cancer Cells via Production of Stromal Cell-Derived Factor-1α To study the interaction between factors secreted by bone marrow mesenchymal stem cells (BM-MSCs) and prostate cancer cells, the authors established an in vitro model of transwell co-culture of BM-MSCs and prostate cancer cells DU145. [Cell Mol Med] Full Article Upregulation of SATB1 Is Associated with Prostate Cancer Aggressiveness and Disease Progression Researchers demonstrated that Special AT-rich binding protein (SATB1) plays significant role in prostate tumor invasion and migration and its nuclear localization correlates with disease aggressiveness. [PLoS One] Full Article Prostate Cancer Stem-Like Cells/Cancer-Initiating Cells Have an Autocrine System of Hepatocyte Growth Factor Prostate cancer stem-like/cancer-initiating cells were isolated as aldehyde dehydrogenase 1-high cells using the ALDEFLUOR assay, and the gene expression profiles were analyzed using a cDNA microarray and RT-PCR. [Cancer Sci] Abstract Platelet-Derived Growth Factor-BB Accelerates Prostate Cancer Growth by Promoting the Proliferation of Mesenchymal Stem Cells Investigators found that mesenchymal stem cells promoted prostate cancer (PCa) tumor growth in vivo and cell proliferation in vitro by using PCa cell strain RM-1. [J Cell Biochem] Abstract CLINICAL RESEARCH Androgen-Deprivation Therapy Alone or with Docetaxel in Non-Castrate Metastatic Prostate Cancer (GETUG-AFU 15): A Randomized, Open-Label, Phase III Trial Scientists investigated the effects of the addition of docetaxel to androgen-deprivation therapy (ADT) for patients with metastatic non-castrate prostate cancer. [Lancet Oncol] Abstract Phase II Open Label, Multi-Center Clinical Trial of Modulation of Intermediate Endpoint Biomarkers by 1α-Hydroxyvitamin D2 in Patients with Clinically Localized Prostate Cancer and High Grade PIN The authors evaluated the biologic activity of a less calcemic vitamin D analog 1α-hydroxyvitamin D2 in patients with prostate cancer and high grade prostatic intraepithelial neoplasia (PIN). [Prostate] Abstract Changes in Serum Prostate-Specific Antigen Levels and the Identification of Prostate Cancer in a Large Managed Care Population Given the questions that remain regarding the use of the rate of change in prostate-specific antigen as a screening tool for prostate cancer because of previous conflicting studies, which to date have included small, highly selected populations, researchers add to the existing knowledge by assessing this question in general practice settings among a large, diverse population. [BJU Int] Abstract | Press Release | Video Press Release |