| PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH ARN-509: A Novel Anti-Androgen for Prostate Cancer Treatment In this study, researchers report the discovery and development of ARN-509, a competitive androgen receptor (AR) inhibitor that is fully antagonistic to AR overexpression, a common and important feature of castration-resistant prostate cancer. [Cancer Res] Abstract AR Intragenic Deletions Linked to Androgen Receptor Splice Variant Expression and Activity in Models of Prostate Cancer Progression Researchers’ data demonstrate that structural alterations in the androgen receptor (AR) gene are linked to stable gain-of-function splicing alterations in castration-resistant prostate cancer. [Oncogene] Abstract Androgen-Regulated miR-32 Targets BTG2 and Is Overexpressed in Castration-Resistant Prostate Cancer Here, researchers identified several androgen-regulated microRNAs (miRNAs) that may contribute to the development of castration-resistant prostate cancer. [Oncogene] Abstract Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of Beta(1,6)-Branched Oligosaccharides as a Marker of Tumor Progression The purpose of this study was to establish xenograft mouse models of metastatic and non-metastatic human prostate cancer and to apply these models for the search of aberrant glycosylation patterns associated with tumor progression in vivo and in patients. [Clin Cancer Res] Abstract Control of Stability of Cyclin D1 by Quinone Reductase 2 in CWR22Rv1 Prostate Cancer Cells In this study on the mechanism of prostate cancer prevention by resveratrol, focusing on the role of its recently discovered target protein, quinone reductase 2 (NQO2), researchers generated NQO2 knockdown CWR22Rv1 using short hairpin RNA-mediated gene silencing approach. [Carcinogenesis] Abstract Critical Role of O-GlcNAc Transferase in Prostate Cancer Invasion, Angiogenesis and Metastasis Here, researchers show O-linked-ß-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is overexpressed in prostate cancer compared to normal prostate epithelium, and OGT protein and O-GlcNAc levels are elevated in prostate carcinoma cell lines. [J Biol Chem] Abstract Livin Regulates Prostate Cancer Cell Invasion by Impacting the Nuclear Factor-κB Signaling Pathway and the Expression of FN and CXCR4 In this study, researchers found that the expression of Livin was higher in metastatic prostate cancer tissues than in nonmetastatic tissues and that the expression of Livin was downregulated/upregulated by small interfering RNA/vector, which could inhibit/promote PC-3/LNCaP cell invasion. [IUBMB Life] Abstract PDGF Upregulates Mcl-1 through Activation of ß-Catenin and Hypoxia-Inducible Factor-1α-Dependent Signaling in Human Prostate Cancer Cells Using experimental models that closely mimic clinical pathophysiology of prostate cancer (PCa) progression, researchers demonstrated that platelet derived growth factor (PDGF) is a survival factor in PCa cells through upregulation of myeloid cell leukemia-1 (Mcl-1). [PLoS One] Abstract Inhibition of Androgen-Responsive LNCaP Prostate Cancer Cell Tumor Xenograft Growth by Dietary Phenethyl Isothiocyanate Correlates with Decreased Angiogenesis and Inhibition of Cell Attachment In this tumor cell xenograft model, dietary administration of phenethyl isothiocyanate inhibited androgen-responsive LNCaP human prostate cancer cell tumor growth. [Int J Oncol] Abstract CLINICAL RESEARCH Dutasteride in Localized Prostate Cancer Management: The REDEEM Randomized, Double-Blind, Placebo-Controlled Trial Researchers aimed to investigate the safety and efficacy of dutasteride, a 5α-reductase inhibitor, on prostate cancer progression in men with low-risk disease who chose to be followed up with active surveillance. [Lancet] Abstract | Press Release Seven Years of Experience with High-Intensity Focused Ultrasound for Prostate Cancer: Advantages and Limitations The aim of this study was to evaluate oncologic outcomes and adverse events for patients with prostate cancer after treatment by high-intensity focused ultrasound. [Prostate] Abstract Cholesterol and the Risk of Grade-Specific Prostate Cancer Incidence: Evidence from Two Large Prospective Cohort Studies with up to 37 Years’ Follow Up Researchers suggest that men with higher cholesterol are at greater risk of developing high-grade prostate cancer but not overall risk of prostate cancer. [BMC Cancer] Abstract |
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